DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP1A and ARHGAP31

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_065805.2	Gene:	ARHGAP31 / 57514	HGNCID:	29216	Length:	1444	Species:	Homo sapiens

Alignment Length:	168	Identity:	54/168 - (32%)
Similarity:	95/168 - (56%)	Gaps:	9/168 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly  1203 FGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLL 1267
            ||..:::.|:...:|:|:::.:|...:|..|::: |.||:||..|::.:|::.|.||  :...|.
Human    19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEFGSD--QCPDLT 80

  Fly  1268 REV---DIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQAN 1329
            |||   |||.|..:.|.:.||||..|.|.:||.:|.:   |.|:..|..::..:..|.:|||.::
Human    81 REVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTE---AVSHCPEEGQLARIQNVIQELPPSH 142

  Fly  1330 KASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLR 1367
            ..::..::.||..:....:...|...|||:|:.|.|||
Human   143 YRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLR 180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619
		PH_BCR_arthropod	851..1037	CDD:270174
		C2	1079..1187	CDD:301316
		RhoGAP	1203..1398	CDD:295372	54/168 (32%)
ARHGAP31	NP_065805.2	RhoGAP_CdGAP	17..211	CDD:239849	54/168 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..427
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..631
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..893
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..1108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1211..1346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940