Protein Alignment RhoGAP1A and arhgap33

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: XP_005158459.3
• Gene: arhgap33 / 569720
• ZFINID: ZDB-GENE-121105-12
• Length: 1907
• Species: Danio rerio
• Alignment Length: 548
• Identity: 117/548 - (21%)
• Similarity: 206/548 - (37%)
• Gaps: 162/548 - (29%)

  Fly   881 VELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEAD-PAVELK---ES 941
            :.:|.||        |..::.||.:.                      ||..| .::||:   |.
Zfish    73 LSVVKGH--------FPKLVDCAHFH----------------------YENVDFGSIELQFANEQ 107

  Fly   942 SPANISQVKRNLRSVRDQL-AMEVANSGS--------GAFRSGDK------YRRK---------L 982
            |.|:.:.     .|.:|.: .::|:..|.        ..||:.|.      |.|:         |
Zfish   108 SDASWTS-----GSAKDLVFLVQVSCQGKTWMVRRSYEEFRTLDAHLHQCIYDRRYSQLLALPAL 167

  Fly   983 ADLESQLVLATP-------NLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANT 1040
            .::..:|.:.||       .|.:.:.||.|...:..::..|....:::     ||::.
Zfish   168 CEIGDRLEILTPLLSEYLNRLTMIVDNKLNCGPVLTWMEIDNHGNRFL-----LKEEA------- 220

  Fly  1041 INSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDL--------------YMGVHGLE-GLE 1090
              ||.|.|...|      ..:..|..:.:::.|:.|||:              :.|.||.: |..
Zfish   221 --SLNVPAIAAA------HVIKRYTAQASDEISIEVGDILSVIDMPPKEDTTWWRGKHGFQVGFF 277

  Fly  1091 QANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAKERPLLKAKH 1155
            .:.    |||                      |.||.              :.::...|:.|.:.
Zfish   278 PSE----CVE----------------------LINEK--------------MPQSVSAPVSKQEV 302

  Fly  1156 ILKLSLSWLTETTQPKSI--------KLTETLELGCSFRFIPGELFRGSTKPGALFGAKMSQVLK 1212
            .|..|....|.||.|.|.        ||...|......|....:|.:.......:||..:.:.|.
Zfish   303 DLMSSKPGATNTTGPSSPTSVSKKHGKLMGFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLL 367

  Fly  1213 REKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLLREV---DIHS 1274
            ....|:|.::.:|...:|:.|::: |.||.||.:|::.||:..|:|:  ....|.::|   |||.
Zfish   368 NSGLDVPQVLTSCSEFIEKHGVVD-GIYRHSGVSSNIQKLRHEFDSE--NVPDLTKDVYMQDIHC 429

  Fly  1275 VTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASITSILDH 1339
            |..:.|.:.||||..|.|.|||.:|.:.....:......::::   |.::||..:..::..::.|
Zfish   430 VGSLCKLYFRELPNPLLTYQLYDKFAECMGEMTEEERMVKVHD---VIQQLPPPHYRTLEYLIRH 491

  Fly  1340 LIRVHEKETDNKMSLHNLAMVFGPTLLR 1367
            |..:.....:..|.:.|||:|:.|.|||
Zfish   492 LAHLATCSAETNMHIKNLAIVWAPNLLR 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619
		PH_BCR_arthropod	851..1037	CDD:270174	34/190 (18%)
		C2	1079..1187	CDD:301316	22/130 (17%)
		RhoGAP	1203..1398	CDD:295372	49/168 (29%)
arhgap33	XP_005158459.3	PX_TCGAP	93..207	CDD:132832	23/118 (19%)
		SH3_ARHGAP32_33	229..282	CDD:212769	10/62 (16%)
		RhoGAP_CdGAP	356..550	CDD:239849	49/170 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030