DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP1A and arhgap32b

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	XP_009293685.1	Gene:	arhgap32b / 569434	ZFINID:	ZDB-GENE-091204-147	Length:	1956	Species:	Danio rerio

Alignment Length:	432	Identity:	101/432 - (23%)
Similarity:	182/432 - (42%)	Gaps:	97/432 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   980 RKLADLESQLVLATPNLVLRLGNKANNK-----TITFFLSSDFERTQWIDSILSLKQKCNLPGAN 1039
            |:.|:..||:::|   .:.||...|:||     .:|           |::    :..|.|....:
Zfish   202 RERAEAVSQMLMA---YLSRLSAIADNKINCGPALT-----------WME----VDNKGNHLLVH 248

  Fly  1040 TINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDL--------------YMGVHGLE-GL 1089
            ..:|:.|.|...|      ..:..|:.:..::.|..|||:              :.|.||.: |.
Zfish   249 EESSINVPAIAAA------HVIKRYIAQAADELSFEVGDIVSVIDMPPKEDTTWWRGKHGFQVGF 307

  Fly  1090 EQANDLYICVEVDSYGHYFRKATTKKICRSQTPL-------WNESF--MLELEGSQNVRILLYEA 1145
            ..:.    |||:  ......::.|..:.:..:|.       |: .|  .||:|..:....|..:
Zfish   308 FPSE----CVEL--INDKVPQSVTNSVPKPASPCSGLRPASWS-LFPPYLEMESIKQDSALAPD- 364

  Fly  1146 KERPL-------LKAKHILKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGELFRGSTKPGALF 1203
               ||       :..||...::.......::|...||.:                ||..:. .:|
Zfish   365 ---PLNPYRLSSVSKKHGKLITFLRTFMKSRPTKQKLKQ----------------RGILRE-RVF 409

  Fly  1204 GAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLLR 1268
            |..:.:.|.....|:|.::.:|...:|:.|::: |.||:||.||::.||:..|:|:  :...|.:
Zfish   410 GCDLGEHLLNSGHDVPQVLKSCTEFIEKHGVVD-GMYRLSGIASNIQKLRHEFDSE--QIPDLTK 471

  Fly  1269 EV---DIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANK 1330
            :|   |||.|..:.|.:.||||..|.|.|||.:|.:..||.::.....:|::   |.::||..:.
Zfish   472 DVYIQDIHCVGSLCKLYFRELPNPLLTYQLYEKFSEAVSAATDEERLIKIHD---VIQQLPPPHY 533

  Fly  1331 ASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQ 1372
            .::..::.||..:........|...|||:|:.|.|||..|.:
Zfish   534 RTLEFLMRHLSHLATFSYVTNMHTKNLAIVWAPNLLRSKQIE 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619
		PH_BCR_arthropod	851..1037	CDD:270174	14/61 (23%)
		C2	1079..1187	CDD:301316	22/138 (16%)
		RhoGAP	1203..1398	CDD:295372	54/173 (31%)
arhgap32b	XP_009293685.1	PX_domain	124..238	CDD:295365	12/53 (23%)
		SH3_ARHGAP32_33	260..313	CDD:212769	10/62 (16%)
		RhoGAP_CdGAP	407..601	CDD:239849	54/175 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030