DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and bcr

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	XP_002665983.2	Gene:	bcr / 568320	ZFINID:	ZDB-GENE-040724-43	Length:	1341	Species:	Danio rerio

Alignment Length:	1537	Identity:	423/1537 - (27%)
Similarity:	639/1537 - (41%)	Gaps:	367/1537 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FQRLWMQRFPQSSLSDAWEQDVRA------SLERHKVRINELSKELEQETLYVEYLERLLS---- 61
            |...|..:||:   |:..:.::|:      .||:.|..|..|..|:.:|...:.||:.||:
Zfish     7 FIEAWKAQFPE---SEPPKMELRSVGGIEQELEKCKASIRRLEMEVNKERFRMIYLQTLLAKERK 68

  Fly    62 --DVERY------RVSGGDPKAL------------------------------------------ 76
              |.:|:      .::.|||:|:
Zfish    69 SYDRQRWGFRKPPHMTEGDPQAVGADSQHLHAQEHGQPERSRFQPVGETRAKPRPPPARKSASHG 133

  Fly    77 --------FEA-ASGSCASSNNSNCSSTTNGATQEESNTNLDKDFKSSLNLRESPSSTGAKDKDR 132
                    ||| ..|..:.::..:.|:...|.:....:...||         |.||....|||..
Zfish   134 DGLELQSSFEAHQPGPVSEADGLSPSTQRGGVSPRRPHPPPDK---------ELPSDPSQKDKAS 189

  Fly   133 LSL-------NPDN-KYTTHTNAVIGGIGSEKVSGPLHSTQITADGKRTGELYLKREEDKCKDSN 189
            :.|       |.:. |.....:|..|..|.||   |.::..         |.:..|...|..|..
Zfish   190 MGLGVAALRSNFERIKRANSHSASDGKSGQEK---PFYTNV---------EFHHDRGLVKVNDRE 242

  Fly   190 SEDTDGAL--QQCITELAASLKAQPDNVA--GGRLENDVDIDKPLRKSTSQYVTVIQVKEAKDKE 250
            ..|...:|  |....|...||.:.|.|:|  .|.|.     .:|:.:..|...|.     ..|.|
Zfish   243 VSDKISSLGNQAMQMERKRSLHSLPGNLATVAGDLR-----ARPVYRGRSTESTC-----GYDAE 297

  Fly   251 SADGTTSSSGIGEPQQQPTPPSTFSRYSEATAPPLSPSLTSYAAHVEAKKKMPPRPPPKNIRRVE 315
            ..||            :|:|     |||                   |.:....:|||
Zfish   298 YEDG------------EPSP-----RYS-------------------AARPNGAKPPP------- 319

  Fly   316 PPTIPSQQLSSSPKRETYMINTMPSSSSGSLCIDSLGNSLERNIKPSDILRQKSSDNLDSKYSAK 380
            ||..||   ...|....|:...||....                              |.:..
Zfish   320 PPWQPS---DFQPYTSVYVGGMMPGEGG------------------------------DGRVP-- 349

  Fly   381 RKTTPELSKFVNVNNPELMEELGRKMVSKADSLEQTRRNDSSPSGCGSLGRTSSTPGRSLTPGR- 444
                              |.|.|                       ||.....:.|.||.:||.
Zfish   350 ------------------MREHG-----------------------GSDDHLLTWPRRSYSPGSY 373

  Fly   445 ---TGVGASPTGSLSKTGKLAMAD---SSSTSSLERRSCLQAVDADIGTESRESGAN----QRSV 499
               .|.|...|...|....|..::   ||..||....|...|....|..:||....|    |.|.
Zfish   374 EDVGGGGGGYTPDCSSNENLTSSEEDFSSGQSSHVSPSPTTAYRRPIREKSRSPSQNSQNSQHSF 438

  Fly   500 GSKESLTSQG----------ISEVQIKSYESVSSLSSESAKAVASQQSAAAGGALAECEPYYDSV 554
            .|....|.|.          :||..|........:.....::|||.:::            :|:.
Zfish   439 DSSSPPTPQTQKRHRQQHVVVSEATIVGVRKTGQIWPHDGESVASSRAS------------HDNS 491

  Fly   555 PLDNGDGEYVFIKPGRTGSSSSRDDLSTPGSSILPLPNVADPESPGRTSNYVNIDFFLQQGIETR 619
            ...:.||.:....| ..|..:.|.:.......|||..:.:...||..:|...:....|..|....
Zfish   492 YHGDLDGPFTGTPP-TYGYDADRAEEQRRHHDILPYIDDSPSSSPHLSSKSRSSRDTLSSGSIES 555

  Fly   620 SSSLDSDGEYEGPPILRTISHDDQTTTQTTPGAIRKNLVSAILVCGNARGAKIRS-ILSSIIQSE 683
            |.|.:.|.|                                       :|.::|. :||.|:.||
Zfish   556 SKSAELDLE---------------------------------------KGLEMRKRVLSGILASE 581

  Fly   684 TIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLSDLKTIVSHEGGDV 748
            ..|:..|..::...|.:.|..||||||:..::..|||||:.|||::|..|...|...|.......
Zfish   582 ETYLSHLEALLLPMKPLKAAATTSQPVLTVQQIETIFFKVPELYEIHKEFYDSLLPRVQQWSHHQ 646

  Fly   749 LIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNLQTE-QSLT----LE 808
            .:|:.|::.|....||.||:.||:.|:||.:||...|.||.:|..::.:....| :.||    ||
Zfish   647 RVGDLFQKQASQLGLYRAFVDNYELAVETAEKCCQANTQFAEISESLKVRSTKECKDLTAKYSLE 711

  Fly   809 DLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVN----QRLPIESNR 869
            .||:|||.||..:.||.:|||:.||::|||:..|:.|.:|.|.||:..|..:    |.:.::...
Zfish   712 TLLYKPVDRVTRSTLVLHDLLKHTPSSHPDYPLLQDALRISQNFLSSINEESTPRRQSMTVKKGE 776

  Fly   870 NLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKAL-GRDRIDYELKWFIPLKDVSIY--EE 931
            | |:::::.|:||||:|.|||||:|||.|::.|||.|.| |.....|:.||:|||.|::..  ||
Zfish   777 N-RQLLKDGFMVELVEGARKLRHVFLFTDLLLCAKLKKLIGGKSQQYDSKWYIPLSDLTFQTAEE 840

  Fly   932 ADPAVELKESSPANISQVKRNLRSVRDQLAME-VANSGSGAFRSGDKYRRKLADLESQLVLATPN 995
            ::| :.:.::....:..:|..:.|:|.::..| .||.||...   ::.::||::.||..:|.:||
Zfish   841 SEP-LPIPQAPDEELDAIKIKISSLRSEIQRERRANKGSKVM---ERLKKKLSEQESLFLLNSPN 901

  Fly   996 LVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKC----NLPGANTINSLEVTAFIVAMQKG 1056
            :.||:.|: |.|:..|.:|||:||.:|.:.|...::||    ||      :|:|:.....:..|.
Zfish   902 MPLRVHNR-NGKSYMFLISSDYERAEWKEVIREQQKKCFKTFNL------SSMELQMLTNSCVKL 959

  Fly  1057 MKTEMGSYLMRNTNDESL-LVGDLYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQ 1120
            .........:....|||. |.|.|.:.||...||:|:.:||..:||||:|.:..||.|:....:.
Zfish   960 QTVHQLPLTVNKEEDESTGLYGFLNVIVHSASGLKQSLNLYCTLEVDSFGIFVNKAKTRVYRYTT 1024

  Fly  1121 TPLWNESFMLELEGSQNVRILLYE------------AKERPLLKAKHILKLSLSWLTETTQPKSI 1173
            .|.|||.|.:|||||..:|:|.||            .:....:..|..:.|....|......:::
Zfish  1025 EPKWNEEFEIELEGSHTLRLLCYEKSYNKAKVNKEDGESTDRIMGKGQMPLDPQMLQGKDWQRTV 1089

  Fly  1174 KLTETLELGCSFRFIPGELF---RGSTKPGALFGAKMSQVLKREKRDIPFIIGACIREVERRGML 1235
            .....:|:..|.:|...|..   ..|.||..:||..:|.|.|||:..:|:|:..|:.|:|||||.
Zfish  1090 IPMNGIEVKISMKFTSREFSLKRMPSRKPMGVFGVNISTVTKRERSKVPYIVRQCLEEIERRGME 1154

  Fly  1236 EVGCYRVSGSASDLAKLKKAFESDAYEAEQLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFF 1300
            |||.|||||.|:|:..||.||:::..:...::.|:|::::.|.||.:.|||||.||||:|||.|.
Zfish  1155 EVGIYRVSGVATDIQALKTAFDTNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDELYPNFA 1219

  Fly  1301 DTFSAFSNN--NESTRINELLKVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGP 1363
            ... |.|::  .||..:|.||    .||:.|..:...:||||.|:.|||..|||||||||.||||
Zfish  1220 GGI-ALSDSVAKESCMLNLLL----SLPEPNLVTFLFLLDHLKRIAEKECVNKMSLHNLATVFGP 1279

  Fly  1364 TLLRPGQTQVK----QKDPLAAS---TVDVMAQAGILYCFLQ 1398
            |||||.:...|    ...|:...   :::||:|..:|..|||
Zfish  1280 TLLRPAEKDSKIPTNPTQPITMGDSWSLEVMSQVQVLLYFLQ 1321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	73/186 (39%)
		PH_BCR_arthropod	851..1037	CDD:270174	69/197 (35%)
		C2	1079..1187	CDD:301316	35/119 (29%)
		RhoGAP	1203..1398	CDD:295372	91/203 (45%)
bcr	XP_002665983.2	Bcr-Abl_Oligo	3..75	CDD:286168	18/70 (26%)
		RhoGEF	573..761	CDD:279015	73/187 (39%)
		PH-like	755..947	CDD:302622	69/203 (34%)
		C2_ABR	983..1103	CDD:176068	35/119 (29%)
		RhoGAP_Bcr	1122..1322	CDD:239852	93/205 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595581
Domainoid	1	1.000	146	1.000	Domainoid score	I4480
eggNOG	1	0.900	-	-		E1_KOG4269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	429	1.000	Inparanoid score	I1706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	1	1.000	-	-		FOG0002220
OrthoInspector	1	1.000	-	-		otm24962
orthoMCL	1	0.900	-	-		OOG6_104879
Panther	1	1.100	-	-	O	PTHR23182
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	1	1.000	-	-		X2211
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790