DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and abr

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_001355623.1	Gene:	abr / 565190	ZFINID:	ZDB-GENE-070705-146	Length:	1061	Species:	Danio rerio

Alignment Length:	1082	Identity:	345/1082 - (31%)
Similarity:	530/1082 - (48%)	Gaps:	162/1082 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 LMEELGRKMVSKADSLEQTRRNDSSPSGCGSLGRTSSTP-GRSLTPGRTGVGASPTGSLSKTGKL 461
            |...:.||. .|.|..:...:.....:.||:..|....| .|.|..|            |||||.
Zfish    59 LQTTIARKK-KKCDIEKCWNKGLKKDNACGTESRGGDEPFARDLLQG------------SKTGKP 110

  Fly   462 AMA----------DSSSTSSLERRSCLQA-VDADIGTESRESGANQRSVGSKESLTSQGISEVQI 515
            .:|          ::|....:......|. .:.|...|..:...||..| .|..|..:|
Zfish   111 ILAPPRKKPEVLQENSPAPDIPESVAEQPNNEPDSDREFEDEELNQNFV-QKNLLVPKG------ 168

  Fly   516 KSYESVSSLSSESAKAVASQQSAAAGGALAECEPYYDSVPLDNGDGEYVFIKPGRTGS------- 573
                :|......:.:...|:.                   :|:.||.:.....|..||
Zfish   169 ----NVRESHRRNPRVRISRD-------------------MDSDDGRFSPYLRGSHGSGRSTPDG 210

  Fly   574 --SSSRDDLSTPGSSILPLPNVADPESPGRTSNYVNIDFFLQQGIETRSSSLDSDGEYEGP---- 632
              ||..||.|:           ||       .|| |.|.:.....|.|.|   .||....|
Zfish   211 YLSSDHDDSSS-----------AD-------FNY-NTDGYEGDPAEDRKS---QDGSETMPFIDE 253

  Fly   633 -----PILRTISHDDQTTTQTTP------GAIRKNLVSAILVCGNARGAKIRSILSSIIQSETIY 686
                 |.|.....|.:..:.|.|      |.|.|.|....||            ||..:.||.||
Zfish   254 SPTMSPHLCARGQDGEAVSPTPPEGLLSGGDIEKGLEMKKLV------------LSGFLASEEIY 306

  Fly   687 VECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLSDLKTIVSHEGGDVLIG 751
            :..|..::...|.:.||.|||:||:..|:.:||||.|.:::::|..|...|...:......|.:|
Zfish   307 INQLEALLLPMKPLKATATTSKPVLTVEQIDTIFFMIQDIFEIHKEFYDALSPHIQQWDEKVTVG 371

  Fly   752 EPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNLQTEQ-----SLTLEDLL 811
            ..|::||....:|.||:.|||.|:..|:|||..|.||:||...:.:....|.     :.|:|.||
Zfish   372 HLFQKLASKLGVYKAFVDNYKLAVGMVEKCSQANIQFQKISENLKVKGPKESKDCTATATMEALL 436

  Fly   812 HKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFN--VVNQRLPIESNR-NLRR 873
            :||:.||..:.||.:|||:.||..|||...|:.|.:|.|.||:..|  :..:|..:.:.: ..|:
Zfish   437 YKPIDRVTRSTLVLHDLLKHTPKDHPDFPLLQDALRISQNFLSSINEEIDPRRTAVTTPKGEARQ 501

  Fly   874 MVRNSFIVELVDGHRKLRHLFLFNDVIACAKYK--ALGRDRIDYELKWFIPLKDVSI--YEEADP 934
            :|::.|:||:.:|.|||||:|||.|::.|||.|  |:||.: .||.||:|||.|:|.  .:|:|.
Zfish   502 LVKDGFLVEVSEGTRKLRHVFLFTDLLLCAKMKKTAVGRHQ-QYECKWYIPLADLSFQTLDESDS 565

  Fly   935 AVELKESSPANISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLR 999
            ...::..:...|.::|..:.|::.::..| ..:..|..|:.|:.|:|:.:.||.|:|.:|.:..|
Zfish   566 LPHVQTLAEHEIEEMKIKISSIKSEIQKE-KKAQKGQSRNVDRLRKKMNEQESCLLLNSPTIPFR 629

  Fly  1000 LGNKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSY 1064
            :.|| :.|:..|.||||:||::|.:||..| ||.:|. |..::|:|:.....:..| ::|.....
Zfish   630 IHNK-HGKSYLFLLSSDYERSEWRESIQKL-QKKDLQ-ACVLSSVELQVLTGSCFK-LRTVHNIP 690

  Fly  1065 LMRNTNDESL--LVGDLYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNES 1127
            :..|.:||..  |.|.|::.||...|.:::.:||..:||||:|::..||.|:....:..|.|||.
Zfish   691 VTSNKDDEESPGLYGFLHVIVHKATGFKESANLYCTLEVDSFGYFVSKAKTRVFRDTTEPQWNEE 755

  Fly  1128 FMLELEGSQNVRILLYEA--------KERPLLKAKHILKLSLSWLTETTQPKSIKLTETLELG-- 1182
            |.:||||||.:|||.||.        |:...:..|.:.|..:....:|.|.|:..: :.:|:.
Zfish   756 FEIELEGSQCLRILCYEKCYDKSKLNKDDNEIVDKIMGKGQVQLDPQTVQSKNWHM-DVIEMNGI 819

  Fly  1183 ---CSFRFIPGELF---RGSTKPGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYR 1241
               .|.:|...:|.   ..|.|...:||.|:|.|.|||:..:|:|:..||.|||:||:.|||.||
Zfish   820 KVEFSMKFTSRDLSLKRTPSKKQSGVFGVKISVVTKRERSKVPYIVRQCIEEVEKRGIDEVGIYR 884

  Fly  1242 VSGSASDLAKLKKAFESDAYEAEQLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAF 1306
            :||.|:|:..||.||:::..:...:|.::||:::.|.||.:.|||||.|.||:|||.|.:   ..
Zfish   885 ISGVATDIQALKAAFDANTKDILMMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFME---GI 946

  Fly  1307 SNNNESTRINELLKVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQT 1371
            |.::.:.:.|.::.:...||..|..:..::|:||.||.|||..|||||||||.|||||||||.::
Zfish   947 SLSDPAAKENCMMHLLRSLPDPNLITFLTLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSES 1011

  Fly  1372 QVKQKDPLAASTV---DVMAQAGILYCFLQ------ARIKKD 1404
            :..:.....||.:   |||||..:|..:||      |.:||:
Zfish  1012 ESSKAQITLASDIWSHDVMAQVQVLLYYLQHPPISFAELKKN 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	70/186 (38%)
		PH_BCR_arthropod	851..1037	CDD:270174	69/192 (36%)
		C2	1079..1187	CDD:301316	38/120 (32%)
		RhoGAP	1203..1398	CDD:295372	87/197 (44%)
abr	NP_001355623.1	Bcr-Abl_Oligo	3..74	CDD:312543	5/15 (33%)
		RhoGEF	295..483	CDD:214619	71/199 (36%)
		PH-like	477..661	CDD:354315	67/187 (36%)
		C2_ABR	707..827	CDD:176068	38/120 (32%)
		RhoGAP_Bcr	846..1042	CDD:239852	88/198 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595584
Domainoid	1	1.000	146	1.000	Domainoid score	I4480
eggNOG	1	0.900	-	-		E1_KOG4269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	1	1.000	-	-		FOG0002220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.780