DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and arhgap12a

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	XP_021336423.1	Gene:	arhgap12a / 563267	ZFINID:	ZDB-GENE-050809-38	Length:	853	Species:	Danio rerio

Alignment Length:	1024	Identity:	214/1024 - (20%)
Similarity:	343/1024 - (33%)	Gaps:	354/1024 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 SKADSLEQTRRNDSSPSGCGSLGRTSSTPGRSLTPGRTGVGASPTGSLSKT------GKLAMADS 466
            ::..:||..|.||:..|.|.|...|:..|.|.    ..|...|||..|...      |.|....:
Zfish    90 NRPSALEIQRPNDNKKSPCPSPSSTALLPPRD----DRGSPVSPTRHLPPAQMNTFPGSLPCFRA 150

  Fly   467 SSTSSL---ERRSCLQAVDADIGTESRESGANQRSVGSKESLTSQGISEVQIKSYESVSSLSSES 528
            .|..|.   ||       |.|..:|.::.|
Zfish   151 ESPGSKLDGER-------DKDKDSERKDRG----------------------------------- 173

  Fly   529 AKAVASQQSAAAGGALAECEPYYDSVPLDNGDGEYVFIKPGRTGSSSSRDDLSTPGSSILPLPNV 593
            .||...::.|..||.       .|...:|:..|:.:        ||.|.|:|.:.||      ..
Zfish   174 EKAAVQEELAEEGGD-------SDKNRIDSESGDEL--------SSGSTDNLQSLGS------GQ 217

  Fly   594 ADPESPGRTSNYVNIDFFLQQGIET----RSSSLDSDGEYEGPPILRTISHDDQ---------TT 645
            ..|:||    .|.|:.........|    .||.:.::|::|        :|.||         :|
Zfish   218 GRPDSP----VYTNLQEMKISQSSTPPLPSSSPIHTNGDWE--------THKDQNGRHYYYNRST 270

  Fly   646 TQTT--PGAIRKNLVSAILVCGNARGAKIRSILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQ 708
            .:.|  |...|.:|                                     ..|:..|....|.
Zfish   271 QERTWKPPRARDSL-------------------------------------PRKEEKHDMTDTE- 297

  Fly   709 PVIREEEENTIFFKIDELYDLHTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMFD-----LYSAFL 768
              :...|||.:..:.|..|                       |.|.|..:|..|     ||....
Zfish   298 --VLSSEENCLSSQSDSQY-----------------------GSPPRGWSEEMDEHGHTLYVCDY 337

  Fly   769 HNYKNAIETVKK-----CSANNPQFKKIVSTIVLNLQTEQSLTLEDLLHKPVARVQINALVFNDL 828
            .|.|....|.::     .||:..:.:..:..|.|..|:..:..:...|||
Zfish   338 TNEKWLRHTDERGRLYYYSADGSRSEWELPKIGLKSQSNHTPLMPGDLHK--------------- 387

  Fly   829 LRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLRR---MVRNSFIVELVDGHRK- 889
            .|......||..|:.:.|:        .::.:.    |:|..|::   .||.||:     ..||
Zfish   388 TRSLDRRLPDPIPISRTQR--------HSIYSH----ETNDKLKQKFVKVRQSFL-----PRRKT 435

  Fly   890 -LR-HLFLFNDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEADPAVELKES-SPANISQVKR 951
             || |.:...|.                  |...|..|.|......|.....|. :..|::::..
Zfish   436 TLRSHPYFPQDT------------------KTGSPDSDSSCPSSPKPPHSPSEKCATLNMTKITE 482

  Fly   952 NLRSVRD---------QLAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNK 1007
            :.:.||.         |.::.:.|.|.|. .||...|.:.:.:|..:.|...::.....:|::.|
Zfish   483 HGKKVRKNWTSYWTVLQGSLLIFNKGQGG-GSGWFGRDQKSSVEYSVDLKGGSVDWASKDKSSKK 546

  Fly  1008 TITFFLSSDFERTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDE 1072
            .:                                  ||           :||..|:.|:..::.:
Zfish   547 HV----------------------------------LE-----------LKTRQGTELLLQSDSD 566

  Fly  1073 SLLVGDLYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLE---LEG 1134
            .|:                 ||             :.||.|:.|   .|.:|.....:|   .|.
Zfish   567 GLV-----------------ND-------------WHKALTEAI---HTYMWESDEAIEEDMPES 598

  Fly  1135 SQNVRILLYEAKERPLLKAKHILKLSLSWLTETTQPKSIKLT------ETLELGCSFRFIPGELF 1193
            .:|.:  ..:.|:|...|....:|.:.| :....|.|..||.      .||:......:|..:
Zfish   599 PENEK--HDKEKDRKNSKKARDIKKTAS-MDNAEQKKKNKLVVLLLGRPTLQAVKDKGYIKDQ-- 658

  Fly  1194 RGSTKPGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFES 1258
                    :||..:|.:.:||...:|..:..||.:||:.|:...|.|||||:.:.:.||:.|...
Zfish   659 --------VFGCSLSSLCQRENSTVPRFVWLCIEQVEKNGLGVDGLYRVSGNLAIIQKLRFAVNH 715

  Fly  1259 DAYEAEQL----LREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELL 1319
            :    |::    .:..|||..||.||.|.|||||.|||   |..|.|..||....:...::..:.
Zfish   716 E----EKIDLGDSKWEDIHVTTGALKMFFRELPEPLFT---YTFFSDFISAIKMPDYKQKVQTVK 773

  Fly  1320 KVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRP 1368
            .:.::||:.|..:|..:..||.:|.:...:|:|:..::|:|||||||||
Zfish   774 DLMKKLPRPNHDTIQVLFKHLKKVIQHVDENRMTTQSVAIVFGPTLLRP 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	31/191 (16%)
		PH_BCR_arthropod	851..1037	CDD:270174	33/201 (16%)
		C2	1079..1187	CDD:301316	22/116 (19%)
		RhoGAP	1203..1398	CDD:295372	61/170 (36%)
arhgap12a	XP_021336423.1	SH3_ARHGAP12	11..70	CDD:213003
		SH3-WW_linker	67..233	CDD:318759	46/213 (22%)
		WW	252..278	CDD:306827	6/33 (18%)
		PH_ARHGAP9-like	470..580	CDD:270053	27/185 (15%)
		RhoGAP_ARHGAP27_15_12_9	660..846	CDD:239868	61/170 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940