Protein Alignment RhoGAP1A and arhgap32a

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: XP_690921.4
• Gene: arhgap32a / 562449
• ZFINID: ZDB-GENE-060503-918
• Length: 1676
• Species: Danio rerio
• Alignment Length: 567
• Identity: 132/567 - (23%)
• Similarity: 216/567 - (38%)
• Gaps: 171/567 - (30%)

  Fly   863 LPIESNRNLRRMVRNSFIVELVDGHRKL----RHLFLFNDVIACAKYKALGRDRIDYELKWFIPL 923
            ||.||  :||..|..:.:  .|...:||    ||   |..:..||.:.
Zfish    69 LPAES--SLRSCVSTASM--KVKNVKKLSLTKRH---FPKLAECAHFH----------------- 109

  Fly   924 KDVSIYEEAD-PAVELKESSPANISQVKRNLRSVRDQLAMEVANSGS--------GAFRSGDK-- 977
                 ||..| .:|:|..:...| ......|.|......:::...|.        ..||..||
Zfish   110 -----YENVDFGSVQLSLTDEQN-DLTNNGLDSKESVYLIQICCQGRKWTVRRSYEEFRVLDKHL 168

  Fly   978 ----YRRKLADLE---------------SQLVLATPNLVLRLGNKANNK-----TITFFLSSDFE 1018
                |.|:.:.|.               ||::.|   .:.||...|:||     .:|
Zfish   169 HLCIYDRRFSQLPELPRIDSLKDKTGTLSQMLTA---YISRLSAIADNKINCGPALT-------- 222

  Fly  1019 RTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDL---- 1079
               |::    :..|.|....|..:|:.|.|  ||....:|    .|:.:..::.|..|||:
Zfish   223 ---WME----IDNKGNHLLVNDESSINVPA--VAAAHVIK----RYIAQAADELSFEVGDIVSVI 274

  Fly  1080 ----------YMGVHGLE-GLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELE 1133
                      :.|.||.: |...:.    |||:.|          :||..:.|
Zfish   275 DMPPKEDTGWWRGKHGFQVGFFPSE----CVELIS----------EKIPSNVT------------ 313

  Fly  1134 GSQNVRILLYEAKERPLLKAKHILKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGELFRGSTK 1198
                      .:..:|:.| ||...::.......::|...||.:                ||..|
Zfish   314 ----------SSLAKPVSK-KHGKLITFLRTFMKSRPTKQKLKQ----------------RGILK 351

  Fly  1199 PGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEA 1263
            . .:||..:.:.|.....|:|.:|.:|...:||.|::: |.||:||.:|::.||:..|:|:  ..
Zfish   352 E-RVFGCDLGEHLLNSGHDVPQVIRSCTEFIERHGVVD-GIYRLSGISSNIQKLRHEFDSE--HV 412

  Fly  1264 EQLLREV---DIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEEL 1325
            ..|.::.   |||||..:.|.:.||||..|.|.|||.:|.|..||.:::....::::   |.::|
Zfish   413 PDLTKDTYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDDERLVKVHD---VIQQL 474

  Fly  1326 PQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQ 1372
            |..:..::..::.||.|:........|...|||:|:.|.|||..|.:
Zfish   475 PPPHYRTLEFLMRHLSRMGTYSNVTNMHCKNLAIVWAPNLLRSKQIE 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619
		PH_BCR_arthropod	851..1037	CDD:270174	43/212 (20%)
		C2	1079..1187	CDD:301316	18/122 (15%)
		RhoGAP	1203..1398	CDD:295372	56/173 (32%)
arhgap32a	XP_690921.4	PX_domain	112..226	CDD:295365	24/132 (18%)
		SH3_ARHGAP32_33	248..301	CDD:212769	10/60 (17%)
		RhoGAP_CdGAP	353..547	CDD:239849	56/175 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030