Protein Alignment RhoGAP1A and si:dkey-91m11.5

DIOPT Version :10

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: XP_005167231.1
• Gene: si:dkey-91m11.5 / 560226
• ZFINID: ZDB-GENE-060503-932
• Length: 1291
• Species: Danio rerio
• Alignment Length: 1494
• Identity: 416/1494 - (27%)
• Similarity: 639/1494 - (42%)
• Gaps: 331/1494 - (22%)

  Fly     7 FQRLWMQRFPQS-----SLSDAWEQDVRASLERHKVRINELSKELEQETLYVEYLERLLSDVERY 66
            |...|..:||.|     ||:..  .|:...||:.:..|..|..|:.:|...:.||:.||:...|
Zfish     7 FVEAWKAQFPDSDPPEMSLNSV--GDIELELEKCRNSIRRLEMEVNKERFRMIYLQTLLAKERR- 68

  Fly    67 RVSGGDPKALFEAASGSCASSNNSNCSSTTNGATQEESNTNLDKDFKSSLNLRESPSSTGAKDKD 131
                                |::|. ....|..:|.|               |:..|..|...|
Zfish    69 --------------------SHDSQ-RWGFNRVSQSE---------------RKPASMDGHHQK- 96

  Fly   132 RLSLNPDNKYTTHTNAVIGGIGSEKVSGPL-HSTQITADGKRTGELYLKREEDKCKDSNSEDTDG 195
                 ||              ||..:...| |||.:              ||.:
Zfish    97 -----PD--------------GSRCLPAKLKHSTAV--------------EESR----------- 117

  Fly   196 ALQQCITELAASLKAQPDNVAGGRLENDVDIDKPLRKSTSQYVTVIQVKEAKDKESADGTTSSSG 260
            ..|||:            .|.||.:.   |:||               ::.:|.| .||.
Zfish   118 EPQQCV------------EVVGGDIS---DLDK---------------QKNRDGE-IDGM----- 146

  Fly   261 IGEPQQQPTPPSTFSRYSEATAPPLSPSLTSYAAHVEAKKKMPP-----------RPPPKNIRRV 314
                       |.:.:.|..|:|.........:...:...:.||           |...:.|||.
Zfish   147 -----------SPYKKRSVETSPRAITGRGPVSQDADGISESPPKVTSGLGVAALRSNFERIRRA 200

  Fly   315 EPPTIPSQQLSSSPKRETYMINTMPSSSSG---------SLCIDSLGNSLERNIKPSDILRQKS- 369
            .     ||..........|.:|.......|         |..|.|||:      :...:.|::|
Zfish   201 N-----SQSSGEGKSERPYYVNMEYHHEKGLVRVNDRDVSEKISSLGS------QAMQMERKRSL 254

  Fly   370 ---SDNLDSKYSAKRKTTPELSKFVNVN------------NPELMEELGRKMVSKADSLEQTRRN 419
               ..||.:.:...||  ||.|....::            ||..:::...::..:....:..:::
Zfish   255 HSVPGNLSTAFGDMRK--PERSHERAIDSGCNCDYEDSDLNPGFLKDSSVRLNGRRAPQQNWQQS 317

  Fly   420 DSSPSGC----GSLGRTS----STPGRSLTPGRTGVGASPTGSLSKTGKLAMADSSSTSSLERRS 476
            |..|...    |.:|...    :.|.||.:||....|.:|             |.||..:|
Zfish   318 DCQPYTTVYVGGIMGDGEDLHLTWPRRSYSPGSFEDGYTP-------------DCSSNENL---- 365

  Fly   477 CLQAVDADIGTESRESGANQRSVGSKESLT--------SQGISEVQIKSYESVSSLSSESAKAVA 533
                      |.|.|..::.:|.....|.|        |:..|:...:|:||.|..:.:|.|.:.
Zfish   366 ----------TSSEEDFSSGQSSHVSPSPTAYRMYREKSRSPSQHSQQSFESGSPPTPQSQKRLK 420

  Fly   534 SQQSAAAGGALAECEPYYDSV-PLDNGDGEYVFIKPGRTGSSSSRDDLSTPGSSILPLPNVADPE 597
            .|.      ||:|.......: |.:.....:         |:|...||..|.|...|...|.|.:
Zfish   421 QQL------ALSEANSGVRKIWPSEGSSNNF---------SNSFHGDLDIPFSGTPPPAYVYDGD 470

  Fly   598 SPGRTSNYVNIDFFLQQGIETRSSSLDSD-GEYEGPPILRTISHDD-----QTTTQTTPGAIRKN 656
                            :|.:.|   |.|| ..|...|:.....|..     :|.:..:|.:.:.:
Zfish   471 ----------------RGDDQR---LQSDIVSYSDDPLFSPRLHPKGRSIRETPSSGSPESTKSS 516

  Fly   657 LVSAILVCGNARGAKIRS-ILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIF 720
            .:.|      .:|.::|. :||.|:.||..|:..|..::...|.:.|..|||||::..::..|||
Zfish   517 ELDA------EKGLEMRKWVLSGILASEEAYLSHLEALLVPMKPLKAAATTSQPMLTLQQIETIF 575

  Fly   721 FKIDELYDLHTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANN 785
            |.:.||:::|..|...|...|........:|:.|::||....:|.||:.|||.|:||.:||...|
Zfish   576 FNVPELHEIHKDFYDGLLPRVQQWSNRQCVGDLFQKLASQLGVYRAFVDNYKIAVETAEKCCQAN 640

  Fly   786 PQFKKIVSTIVLNLQTEQSL--TLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKI 848
            .||.:|...:.:....:|:.  :||.||:|||.||..:.||.:|||:.||::|||:..|:.|.:|
Zfish   641 SQFAEISENLKVKSAKDQNAKHSLETLLYKPVDRVTRSTLVLHDLLKHTPSSHPDYPLLQDALRI 705

  Fly   849 IQMFLNQFNVV----NQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKY-KAL 908
            .|.||:..|..    .|.:.::...| |:::|:.|:||||:|.|||||:|||.|::.|||. |..
Zfish   706 SQNFLSSINEEITPRRQSMTVKKGEN-RQLLRDQFMVELVEGARKLRHVFLFTDILLCAKLKKQT 769

  Fly   909 GRDRIDYELKWFIPLKDVSIY----EEADPAVELKESS----PANISQVKRNLRSVRDQLAMEVA 965
            |.....|:.||:|||.||:..    .|:.|..::.|..    ...|||:|..:     |....|.
Zfish   770 GGKGQQYDCKWYIPLADVTFQTIDESESSPVPQIPEEEIDALKVKISQIKNEI-----QREKRVC 829

  Fly   966 NSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLK 1030
            ..|    :..|:.|:||.:.||.|:|.:|.:..|:.|: |.|..||.:|||:||.:|.:.|...:
Zfish   830 KGG----KVLDRLRKKLCEQESLLLLMSPCMAFRVSNR-NGKGYTFLISSDYEREEWREVIREQQ 889

  Fly  1031 QKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESL-LVGDLYMGVHGLEGLEQAND 1094
            :||.  .:.::.|||:.....:..|..........:...:|||. |.|.|.:.||...||:|:.:
Zfish   890 KKCF--KSFSLTSLELQMLTNSCVKLQTVHSIPLTVNKDDDESTGLCGFLNVIVHSATGLKQSLN 952

  Fly  1095 LYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLY--------EAKERPLL 1151
            ||..:||||:|::..||.|:....:..|.|||.|.:||||||.:|:|.|        :.:....:
Zfish   953 LYCTLEVDSFGYFVNKAKTRVYRDTTEPNWNEEFEIELEGSQTLRLLCYSKIKQCRDDGENIDRV 1017

  Fly  1152 KAKHILKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGELF---RGSTKPGALFGAKMSQVLKR 1213
            .||..::|....|......:::.....:|:..|.||...|..   ..|.|...:||.|:..|.||
Zfish  1018 MAKGQIQLDPQSLQGKDWQRTVISMNGIEVKLSMRFTSREFSLKRMPSRKQSGVFGVKIGAVTKR 1082

  Fly  1214 EKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLLREVDIHSVTGI 1278
            |...:|.|:..|:.|:|||||.|||.|||||.|:|:..||.||:::..:...::.|:|::::.|.
Zfish  1083 EHSKVPLIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDANNKDVSVIMSEMDVNAIAGT 1147

  Fly  1279 LKTFLRELPEALFTDQLYPRFFDTFSAFSNN--NESTRINELLKVFEELPQANKASITSILDHLI 1341
            ||.:.|||||.||||:||..|.:.. |.|::  .||..:|.||    .||:.|..:...:||||.
Zfish  1148 LKLYFRELPEPLFTDELYINFTEGI-ALSDSVAKESCMLNLLL----SLPEPNLLTFLFLLDHLK 1207

  Fly  1342 RVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVK----QKDPLAAS---TVDVMAQAGILYCFLQ 1398
            ||.|.|..||||.||||.|||||||||.:...|    ...|::.|   :::||:|..:|..|||
Zfish  1208 RVAENEIVNKMSFHNLATVFGPTLLRPSEKDSKIPSNPTQPISMSDSWSLEVMSQVQVLLYFLQ 1271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	69/183 (38%)
		PH_BCR_arthropod	851..1037	CDD:270174	69/198 (35%)
		C2	1079..1187	CDD:472691	36/115 (31%)
		RhoGAP	1203..1398	CDD:470621	90/203 (44%)
si:dkey-91m11.5	XP_005167231.1	Bcr-Abl_Oligo	3..75	CDD:430380	21/91 (23%)
		RhoGEF	527..714	CDD:238091	70/186 (38%)
		PH_BCR_vertebrate	709..901	CDD:270173	69/204 (34%)
		C2_ABR	937..1053	CDD:176068	36/115 (31%)
		RhoGAP_Bcr	1072..1272	CDD:239852	92/205 (45%)