Protein Alignment RhoGAP1A and ARHGAP15

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: NP_060930.3
• Gene: ARHGAP15 / 55843
• HGNCID: 21030
• Length: 475
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 128/566 - (22%)
• Similarity: 216/566 - (38%)
• Gaps: 156/566 - (27%)

  Fly   826 NDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLRRMVRNSFIVELVDGHRKL 890
            :|...||.|:      .||....:||.:...|..:.||....:..|..:.:   :.|.:..||:.
Human     7 SDTSVETLNS------TRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGK---VTEPISRHRRN 62

  Fly   891 RHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEE--------ADPAVELKES-SPANI 946
            ....:..|||.                    ||:.:.:.:|        ||...:|::: |.:.|
Human    63 HSQHILKDVIP--------------------PLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWI 107

  Fly   947 SQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADL-----ESQLVLATPNLVLRLGNKANN 1006
            ....|.:...::.....::|..:|       ::.:..||     |.....::...|.::...:.|
Human   108 VLSSRRIEFYKESKQQALSNMKTG-------HKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGN 165

  Fly  1007 KTITFFLSS--DFERTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNT 1069
            :   |.|.|  ||....|..:|.:...:  ||..::..|..:..|  .:|:...||:.|
Human   166 E---FLLQSDIDFIILDWFHAIKNAIDR--LPKDSSCPSRNLELF--KIQRSSSTELLS------ 217

  Fly  1070 NDESLLVGDLYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEG 1134
                                                ||      ....:.|.|...:|.|..|..
Human   218 ------------------------------------HY------DSDIKEQKPEHRKSLMFRLHH 240

  Fly  1135 SQNVRILLYEAKERPLLKAKHILKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGELFRGSTKP 1199
            |.:      :..::..:|::  ||..:     |.:|....|.|                :|..|
Human   241 SAS------DTSDKNRVKSR--LKKFI-----TRRPSLKTLQE----------------KGLIK- 275

  Fly  1200 GALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKL--------KKAF 1256
            ..:||:.:.:|.:||...:|:.:..||..||:||:...|.|||||:.:.:.||        |...
Human   276 DQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNL 340

  Fly  1257 ESDAYEAEQLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKV 1321
            :...:|        |||.|||.||.|.|||||.||....:.:|.:......||   |||..:..:
Human   341 DDSQWE--------DIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNN---TRIEAVKSL 394

  Fly  1322 FEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLR 1367
            .::||..|:.::..:..||.::..|.:.|.||..:|.:||||||||
Human   395 VQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLR 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	8/30 (27%)
		PH_BCR_arthropod	851..1037	CDD:270174	35/201 (17%)
		C2	1079..1187	CDD:301316	15/107 (14%)
		RhoGAP	1203..1398	CDD:295372	62/173 (36%)
ARHGAP15	NP_060930.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		6/21 (29%)
		PH	80..188	CDD:278594	21/117 (18%)
		PH_ARHGAP9-like	81..190	CDD:270053	21/118 (18%)
		RhoGAP_ARHGAP27_15_12_9	279..465	CDD:239868	62/173 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940