DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP1A and RhoGAP19D

DIOPT Version :9

Sequence 1:NP_001284725.1 Gene:RhoGAP1A / 5740235 FlyBaseID:FBgn0025836 Length:1404 Species:Drosophila melanogaster
Sequence 2:NP_001285496.1 Gene:RhoGAP19D / 33048 FlyBaseID:FBgn0031118 Length:2206 Species:Drosophila melanogaster


Alignment Length:1590 Identity:294/1590 - (18%)
Similarity:504/1590 - (31%) Gaps:547/1590 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 ASSNNSNCSSTTNGATQEESNTNLDKDFKSSLNLRESPSS-------TGAKDKDRLSLNP----- 137
            :||.:...|.:...||....:||..::..|:.......||       ||.:.....||.|     
  Fly    83 SSSASGLVSGSATAATAASVSTNWPQEASSAAGSNSGSSSSVGVAGITGLEPTSPTSLPPYQVKA 147

  Fly   138 ----------DNKYTTHTNAVIGG----IGSEKVSGPLHSTQITADGKRTGELYLKREEDKCKDS 188
                      .|....:.|...|.    :.::.::|..:||.::...:....|.|.....:|   
  Fly   148 METIFIKEVQANGPAHYANLQTGDRVLMVNNQPIAGIAYSTIVSMIKQTPAVLTLHVVPKEC--- 209

  Fly   189 NSEDTDGALQQCITELAASLKA--------QPDNVAGGRLENDVDIDKPLRKSTSQYVTVI---- 241
                  ..||...|.:|.:.::        .|..:|.|.           .|:|......:    
  Fly   210 ------DVLQMHYTSIAHTPESNRLTMSTHSPSLLANGS-----------HKTTFPAAAAVAAPP 257

  Fly   242 -----QVKEAKDKESADGTTSSSGIGEPQQQPTPPSTFSRYSEATAPPL-----SPSLTSYAA-- 294
                 |.::.....:....|:|:..|.||.| :...:.|..:...||.|     |.|:||.|:  
  Fly   258 HQHQQQQQQLISYPAVAAVTTSTPAGSPQSQ-SQSQSHSHPNTHHAPSLHGGSRSGSITSTASGG 321

  Fly   295 ------------HVEAKKKMPPRPPP-----------------------------------KNIR 312
                        ..:.:::...|.|.                                   :.:|
  Fly   322 ITVLSQPFYPQQQQQQQQQQQHRHPALTGGSSSIDFGDMAHGLRQHQQQQQHLYQQQQQHHQFMR 386

  Fly   313 RVEPPTIPSQQLSSS----------PKRET------YMINTMPSSSSGSLCIDSLGN-SLERNIK 360
            ..:||.:.....||:          ||..|      |.:...|||::||      |: ||....:
  Fly   387 ANQPPNLTVLSASSATNTPTPTARQPKSATSHNQALYAVGAGPSSAAGS------GSGSLSGGSE 445

  Fly   361 PSDILRQKSSDNLDSKYSAKRKTTPELSKFVNVNNPELMEELGRKMVSKADSLEQTRRNDSSPSG 425
            .||::       :..:.|.|:|     .:|:....|..|        |.|.|:...:...|||:.
  Fly   446 NSDLM-------IRLRESIKQK-----EEFLKSPVPASM--------SSASSINGNQAQSSSPAQ 490

  Fly   426 CGSLGR------TSSTPGRSLTPGRTGVGASPTGSLSKT-------------------------- 458
            ...|.:      .|.||     ||...|...|..|..:.                          
  Fly   491 QQHLQQHQQHFFPSHTP-----PGGVQVVVPPPRSRHQVMLKQQQQQQQQHQQHHVLGYDMYHSG 550

  Fly   459 GKLAMADSSSTSSL---------------ERRSCLQ---------------AVDADIGTESRESG 493
            |||....|::..|:               ::...||               |.|.|.....:|:|
  Fly   551 GKLVQRSSTAPGSVCHQHQQQQQHHLYHQQQHQQLQQTQHRQVMINNNAKYAKDLDYFETLQETG 615

  Fly   494 ANQRSVGSK-ESLTSQGIS-----EVQIKSYESVSSLSSESAKAVASQQSAAAGGALAECEPYYD 552
            ...:....| .|..|:|..     .:...:.||.:|.||.||.....:||.           .|:
  Fly   616 VTNKVFERKLVSHMSKGFDPFKPLSINTSALESSASTSSTSATTTVKKQSV-----------LYE 669

  Fly   553 SV---PLDNGDGEYVFIKPGRT------GSSSSRDDL---STPGSSILPLP-----NVADPESPG 600
            |:   ||    .:|...:...|      |.:|||.:|   :...::|.|:|     .|..|:.|.
  Fly   670 SLQQHPL----AKYHQTQQQTTTTTTVDGQTSSRMELHKATLANATIDPVPVGSSKFVTLPDKPD 730

  Fly   601 RTSNYVNIDFFLQQG----IETRSSS---------LDSDGEYEGPPILRTISHDDQTTTQTTPGA 652
            :.|:...:....:..    :::.|.|         |.|....||.| :|.||:...|..:|...|
  Fly   731 KGSSVATLADIAESSAAAIVDSASGSGNVVRRYKPLSSSSFDEGKP-MRRISYLRATNNETDFNA 794

  Fly   653 IRKNLVSAILVCGNARGAKIRSILSS------------------IIQSETIYVECLNKMMQYKKA 699
              :...........|.|....|..||                  :..|..|.|..:.:..:.|..
  Fly   795 --EAAAGGDAAATGASGPASASAASSAPGPTPSSAPAPAPAPAPLPISIPIPVAAVVEPQKTKSL 857

  Fly   700 IHATLTTSQPVIREEEENTIFFKIDELYDL--HTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMFD 762
            :              ||:.     |..||:  .||            ||...|..|         
  Fly   858 V--------------EEHP-----DPTYDVIGGTG------------GGHEFIETP--------- 882

  Fly   763 LYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNLQTEQSLT---LEDLLHKPVARVQINALV 824
                      |.:|.| :.||:..:...:.|.:..::..:..|.   :.:.|......::|.:..
  Fly   883 ----------NGLEDV-RLSAHGSRRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSC 936

  Fly   825 FNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLRRMVRNSFIVELVDGHRK 889
            .|.      ....:::..||.         :..:....|.|.|.|                 |.|
  Fly   937 ING------KRMSEYRSWRQV---------KLEIKGDLLRIYSGR-----------------HAK 969

  Fly   890 LRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNLR 954
            ..|     :||               ||       |:..::..|.:::.|               
  Fly   970 SEH-----NVI---------------EL-------DIRNFKFFDESMDKK--------------- 992

  Fly   955 SVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFER 1019
              :..:.|:...|.|||         .||.|.::|.|          ::.::|.:|...||    
  Fly   993 --KYLIRMQSKPSPSGA---------HLASLGNELNL----------DEGHDKLLTSSGSS---- 1032

  Fly  1020 TQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDLYMGVH 1084
                        ..|.|.||..::|..:........|..||: .:..:::|:           :.
  Fly  1033 ------------SANEPAANAASALTASTSSSTCSSGPYTEI-LFKTKSSNE-----------MK 1073

  Fly  1085 GLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAKERP 1149
            .|.||.|..|   .:..|...|   :...|::...|..:.:.|::.:::|..:.      |...|
  Fly  1074 RLFGLLQWKD---SLNYDDNEH---QPQGKQLAEPQKTVASASYLDDVQGGASA------ADSSP 1126

  Fly  1150 LLK----------AKHILKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGE------------- 1191
            |..          :.|:..|..:.........||..........|.:.||.:             
  Fly  1127 LSSHSGGIADASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSKNWKDL 1191

  Fly  1192 LFR----GS--------TKPGALFGAKMSQV--------LKREKRDIPFIIGACIREVERRGMLE 1236
            |||    ||        ..|.|....::..:        :.:....:|.::..|...||.:|:..
  Fly  1192 LFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGV 1256

  Fly  1237 VGCYRVSGSASDLAKLKKAFESDAYEAEQLL---REVDIHSVTGILKTFLRELPEALFTDQLYPR 1298
            ||.||:.|:.:.:::|.:...:..::.|...   |..|::.|:.:||.|:|.||:||.....|..
  Fly  1257 VGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYIN 1321

  Fly  1299 FFDTFSAFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGP 1363
            |.:....|.    ..||..|.::.|.||:....::..::.||.||......|:|...|||::|||
  Fly  1322 FIEADKKFG----LERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGP 1382

  Fly  1364 TLLRPGQTQVKQKDPLAASTVDVMAQAGIL 1393
            :::|      ...|.|..:..|:..|..|:
  Fly  1383 SIIR------TPNDTLETAVKDMKHQCRIV 1406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP1ANP_001284725.1 RhoGEF 675..857 CDD:214619 29/204 (14%)
PH_BCR_arthropod 851..1037 CDD:270174 29/185 (16%)
C2 1079..1187 CDD:301316 19/117 (16%)
RhoGAP 1203..1398 CDD:295372 50/202 (25%)
RhoGAP19DNP_001285496.1 PDZ_signaling <151..205 CDD:238492 8/53 (15%)
RhoGAP_ARHGAP21 1221..1417 CDD:239860 50/196 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2255
SonicParanoid 00.000 Not matched by this tool.
21.940

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