DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and arhgap21b

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	XP_001918968.3	Gene:	arhgap21b / 326745	ZFINID:	ZDB-GENE-030131-4944	Length:	1793	Species:	Danio rerio

Alignment Length:	1457	Identity:	282/1457 - (19%)
Similarity:	456/1457 - (31%)	Gaps:	538/1457 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 ESPSSTGAKDKDRLSL-NPDNKYTTHTNAVIGGIGSEKVSGPLHSTQITADGKRTGELYLKREED 183
            ||...:..||:|.... .|.|:........:..:   |..||.||.     |..||:..:|...:
Zfish    75 ESAMHSNFKDEDHSHRGRPRNRLEPMDTIFVKQV---KEGGPAHSA-----GLCTGDRIVKVNGE 131

  Fly   184 KCKDSNSEDTDGALQQCITELAASLKAQPDNVAGGRLENDVDIDKPLRKSTSQYVTVIQVKEAKD 248
            ...........|.:|...|.|...:           :..|.||              :|:..::|
Zfish   132 SIIGKTYSQVIGLIQNSHTFLELCV-----------MPKDEDI--------------LQLAYSQD 171

  Fly   249 KESADGTTSSSGIGEPQQQPTP---------PSTFSRYSEATAPPLSPSLTSYAAHVEAKKKMPP 304
             ....|..:.||......:|.|         |...::.:|.:||.:..|...|...:    .:||
Zfish   172 -AYLKGHDAYSGNARHIPEPPPICYPRVDCKPPGMAQATETSAPGVVSSDLGYRVEI----PVPP 231

  Fly   305 RPPP-------------KNIRRVEPPTIPSQQLSSSPKRETY--------MINTMPSSSSGSLCI 348
            .|||             :::|.|..|......|.....|..|        :|...|.:.||.
Zfish   232 SPPPPIPKTQTAVCVCNESVRTVVVPPDVHMGLMVQGHRGDYGLVGPDPMLIRARPGTVSGG--- 293

  Fly   349 DSLGNSLERNIKPSDILRQKSSDNLDSKY-------------SAKRKTTPELSKFVNVNNPELME 400
                       :| ..|..:.:|...|.|             .|...|:|...:.::....:...
Zfish   294 -----------RP-PYLHPRKADMFPSGYHGDPYAIPPTHYVPASSITSPATHQNIDWRTYQTYR 346

  Fly   401 E---------LGRKMVSKADSLEQTRRNDSSPSGCG-------SLGRTSST-----PGRSLTPGR 444
            |         ..|.:..:.|||....::......||       .|.|.|::     .|.|:.|.|
Zfish   347 EYIDNKGIHAYSRTVQERLDSLRAASQSTHGGPHCGPQPGWGNKLRRRSTSHDRAYQGPSMLPPR 411

  Fly   445 TG-----VGAS--------PTGSLSKTGKLAMADSSSTSSLERRSCLQA------VDADIGTESR 490
            :.     .||.        |..|:|..|.:....:.|:..:|....:.|      ||..:
Zfish   412 SASQDRMSGAERAAHARDWPPRSVSSDGLIRKPRAHSSDYVEHGELVSAAPWAAPVDRQL----- 471

  Fly   491 ESGANQRSVGSKESLTSQGISEVQIKSYESVSSLSSESAKAVASQQSAAAGGALAECEPYYDSVP 555
            .|..:|||..|::||                      ..:||..:.....|.::.
Zfish   472 YSRVDQRSRPSRQSL----------------------PPRAVLYRPPTGYGMSVR---------- 504

  Fly   556 LDNGDGEYVFIKPGRTGS--SSSRDDLSTPGSSILPLPNVADPESPGRTSNYVNIDFFLQQGIET 618
                         |..||  .|||.|:.         |....||.|   .|.:|      |..|.
Zfish   505 -------------GNAGSHKHSSRTDIP---------PTAGFPERP---RNGIN------QAKEP 538

  Fly   619 RSSSLDSDGEYEGPPILRTISHDDQTTTQTTPGAIRKNLVSAILVCGNARGAKIRSILSSIIQSE 683
            .|.  |..|...|..||.:.|:..:|..:|                               :||
Zfish   539 PSK--DQSGTVVGNRILNSASNQSRTRAET-------------------------------MQS- 569

  Fly   684 TIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLSDLKTIVSHEGGDV 748
                                                                      ...|.|:
Zfish   570 ----------------------------------------------------------PESGKDI 576

  Fly   749 LIGEPFRRLAEMFDLYSA-FLHNYKNAIETVKKCSANNPQFKKIVSTIVLNLQTEQSLTLEDLLH 812
            .:|  :|..:     ||| .|...|....|.:..|.:           |..|....|..:|.:
Zfish   577 SVG--YRSAS-----YSAPPLQRPKGGASTQRTSSRD-----------VKGLPVNGSSPVEGV-- 621

  Fly   813 KPVARVQINALVFNDLLRE-TPNAHPDHQPLRQAQKIIQMFLNQFNVVNQR------------LP 864
                           :||| .|......||||....|:        .||..            ||
Zfish   622 ---------------VLREKPPTGKGTPQPLRHPSYIL--------AVNDTDGSEPAGGGVCWLP 663

  Fly   865 IESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKDVSIY 929
            .::.|.:|                 ::.|....|...|:       ..:|..|. .||..|
Zfish   664 NDARREMR-----------------MQRLGERLDSSFCS-------SNLDESLD-SIPFID---- 699

  Fly   930 EEADPAVE------------------LKES-SPANISQ-VKRNLRSVRDQLAMEVANSGSGAFRS 974
            |.|.|:|:                  |.:| ||:..|. ::|.|...::.|...:..||:...||
Zfish   700 EPASPSVDHDGSHIPASVVISGAQAALSDSPSPSTPSPLMRRQLSHDQESLRNAILESGTKTERS 764

  Fly   975 G------DKYRRKLADLESQLVLATPNL-VLRL---GNKANN----KTITFFLSSDFERTQWIDS 1025
            .      |.||.:.....|:     |:| |.|.   |:|:::    :..:..:.||..:..|
Zfish   765 KSYDEGLDNYREEGRGRSSK-----PSLRVFRKALDGHKSDDSSSRRDSSTEIFSDSTKEGW--- 821

  Fly  1026 ILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVG-DLYMGVHGLEGL 1089
             |..:|      .||.....|..       ||:.....|        ::|.| .||:.....|||
Zfish   822 -LHFRQ------LNTEKGKRVGG-------GMRPWKQMY--------AVLRGHSLYLYKDKKEGL 864

  Fly  1090 EQAN----------DLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQN----VRI 1140
            ...|          .:..|:...||....|    |.:.|..|.  :..::.:.||.::    :|:
Zfish   865 AHVNSQLEDDPQSISIKACLIDISYSDTKR----KNVLRLTTS--DCEYLFQAEGREDMLSWIRV 923

  Fly  1141 LLYEA---KERPLLKAKHILK------LSLSWLTETTQP------KSIKLTETLELGCS------ 1184
            :...:   :|...:.:..::.      :|:|..:..|:|      :|:.:.:||..|.|
Zfish   924 IQENSNLDEENAAVTSTDLINRKLKEYISMSAPSSKTEPSPKTSRQSLSIRQTLLGGSSKSQSPY 988

  Fly  1185 ----------------------FRFIPGELFRGSTK---PGALFGAKMSQVLKRE-KRDIPFIIG 1223
                                  .|.|||...:...|   .|..||.::......: .:.:|.|:.
Zfish   989 SPKNEQDRSKDDSSPPRDKAAWRRGIPGLKKKPQDKRPAAGVTFGVRLDNCPPAQTNKFVPLIVE 1053

  Fly  1224 ACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLLREVDIHS--------VTGILK 1280
            .|.:.||.||:...|.|||.|:.:.::.:::..::..      :.::||..        ::.:||
Zfish  1054 VCCKLVEDRGLEYTGIYRVPGNNAAISSMQEELDTKG------MTDIDIQDDKWRDLNVISSLLK 1112

  Fly  1281 TFLRELPEALFTDQLYPRFFDTFSAFSNNNES--TRINELLKVFEELPQANKASITSILDHLIRV 1343
            :|.|:|||.|||::.|..|.|     :|..|.  .|:..|.::..|||..:..::..:..||..|
Zfish  1113 SFFRKLPEPLFTNEKYSNFID-----ANRMEDPVERLKALKRLIHELPDHHYETLKFLSGHLKTV 1172

  Fly  1344 HEKETDNKMSLHNLAMVFGPTLLRPGQ 1370
            .|....|||...|||:||||||:|..:
Zfish  1173 SENCEKNKMEPRNLAIVFGPTLVRTSE 1199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	26/183 (14%)
		PH_BCR_arthropod	851..1037	CDD:270174	45/231 (19%)
		C2	1079..1187	CDD:301316	26/164 (16%)
		RhoGAP	1203..1398	CDD:295372	53/179 (30%)
arhgap21b	XP_001918968.3	PDZ_signaling	50..156	CDD:238492	20/88 (23%)
		PH_ARHGAP21-like	817..931	CDD:269955	27/144 (19%)
		PH	817..926	CDD:278594	27/139 (19%)
		RhoGAP_ARHGAP21	1031..1227	CDD:239860	53/180 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940