DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and Graf

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_001285296.1	Gene:	Graf / 32522	FlyBaseID:	FBgn0030685	Length:	1025	Species:	Drosophila melanogaster

Alignment Length:	714	Identity:	149/714 - (20%)
Similarity:	257/714 - (35%)	Gaps:	245/714 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   770 NYKNAIETV--KKCSANNPQFKKIVSTIVLNLQTEQSLTLEDLLHKPVARVQINALVFNDLLRET 832
            |.:..:|.:  ::|..::|.|::       ||...:. .|:...|: :.|:          ::|.
  Fly     6 NVRRGLEPLEFEECIVDSPDFRE-------NLNRHEK-ELDHTSHQ-IKRI----------IKEV 51

  Fly   833 PNAHPDHQPLRQAQKIIQMFLNQF-------------NVVNQRLP--------IESNRNLRRMVR 876
            .:.....:.|....|.:.:.||.|             ||:.:.|.        ||..|.....:.
  Fly    52 KDLMSAAKILSTRMKQLAILLNDFNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLA 116

  Fly   877 NSFIVELVDGHRKLRHLFLFNDVIACAKYKALG-----RDRIDYELKWFI----------PLKDV 926
            :..|:|.::..||                |.:|     :.:.|.:.:.|.          ..|..
  Fly   117 DKHIIESLEDFRK----------------KQIGGVKENKKKFDKKTEKFCQSQERFLNMSTKKPE 165

  Fly   927 SIYEEADPAVEL--KESSPANISQVKRNLRSVRDQLAMEVAN------SG-----SGAFRSGDKY 978
            :..:|||.::.:  :|....::|.|.| ::.|::::..|...      ||     ..|....:.:
  Fly   166 NTIQEADASLGMHEREYIQESLSYVLR-IQEVQERIKFEFVEILLAFISGWLVFYHTAHEQAEDH 229

  Fly   979 RRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANTINS 1043
            |..|.||..::                .||     ..:||..:  :.:..||.|
  Fly   230 RDYLQDLRHKV----------------QKT-----RENFEEAR--EKVTELKTK----------- 260

  Fly  1044 LEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLV--GDLYMGVHGLEGLEQANDLYICVEVDSYGH 1106
                                |:.:.|..|.:..  |.|::       :|:::.|.|     |...
  Fly   261 --------------------YMEKRTKPEEIFTKRGYLFL-------MEKSSILKI-----SLLE 293

  Fly  1107 YFRKATTKKIC------RSQTPL----WNESFMLELEGSQNVRILLYEA---------------- 1145
            .|:...||..|      |..|.|    .|.:| ...|...:.::.|:..
  Fly   294 PFKATWTKYYCTFKKQKREFTMLQFNQMNHNF-TRPEARDDEKLTLFSCQRRASEFEKRFCFDLT 357

  Fly  1146 -KERP--------LLKAKHILKLSLSWLTETT--QPKSIKLTETLELGCSFRFIPGELFRGSTKP 1199
             ||:|        |.:..|...:|....||.|  .|..||::|...|               .:.
  Fly   358 FKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGKIKVSEAYHL---------------DEA 407

  Fly  1200 GALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKL------KKAFES 1258
            |.:|                  |..||:.:|.||:.:.|.||.||..:.::||      :|  ||
  Fly   408 GFMF------------------IRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQK--ES 452

  Fly  1259 DAYEAEQLLRE-VDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVF 1322
            |....:...|: ::.:::...||.:||.|.|.|.|.|.:..|.:   |......:.|:||:.|:.
  Fly   453 DDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIE---AAKQETLNQRVNEVHKLV 514

  Fly  1323 EELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVKQKDPLAASTVDV 1386
            .:|||.|...:..::.||..|..|...||||:.||.:|||||||||.:..|       |:.:|:
  Fly   515 YKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESV-------AAILDI 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	16/101 (16%)
		PH_BCR_arthropod	851..1037	CDD:270174	41/234 (18%)
		C2	1079..1187	CDD:301316	30/144 (21%)
		RhoGAP	1203..1398	CDD:295372	60/191 (31%)
Graf	NP_001285296.1	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	39/241 (16%)
		BAR-PH_GRAF_family	273..390	CDD:269953	25/129 (19%)
		PH	279..383	CDD:278594	21/116 (18%)
		RhoGAP	383..584	CDD:295372	69/234 (29%)
		SH3_GRAF-like	967..1020	CDD:212815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940