DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP1A and Bcr

DIOPT Version :9

Sequence 1:NP_001284725.1 Gene:RhoGAP1A / 5740235 FlyBaseID:FBgn0025836 Length:1404 Species:Drosophila melanogaster
Sequence 2:XP_038955099.1 Gene:Bcr / 309696 RGDID:1307993 Length:1270 Species:Rattus norvegicus


Alignment Length:1514 Identity:418/1514 - (27%)
Similarity:642/1514 - (42%) Gaps:392/1514 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 FQRLWMQRFPQS--------SLSDAWEQDVRASLERHKVRINELSKELEQETLYVEYLERLLS-- 61
            |...|..:||.|        |:.     |:...|||.|..|..|.:|:.||...:.||:.||:  
  Rat     7 FAEAWRAQFPDSEPPRMELRSVG-----DIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKE 66

  Fly    62 ----DVERYRVSGGDPKALFEAASGSCASSNNSNCSSTTNGATQEESNTNLDKDFKSSLNLRESP 122
                |.:|:.         |..|            :...:||.:..:         |:..|..:|
  Rat    67 KKSYDRQRWG---------FRRA------------AQPPDGAAEPRA---------SAPRLPPAP 101

  Fly   123 SSTGAKDK--DRLSLNPDNKYTTHTNAVIGGIGSEKVSGPLHSTQITADGKRTGELYLKREEDKC 185
            :. ||...  :.....||            |.||.....|       |..:|.........:|:.
  Rat   102 AD-GADPAPVEESEARPD------------GEGSPSKGRP-------ATARRPAAAAPADRDDRG 146

  Fly   186 KDSNSEDTDGALQQCITELAASLKAQPDNVAGGRLE-NDVDIDKPLRKSTSQYVTV--------- 240
            ..::               .|:|::..:.:..|..: ...|.:||.      ||.|         
  Rat   147 PPTS---------------VAALRSNFEKIRKGPAQPGSADAEKPF------YVNVEFHHERGLV 190

  Fly   241 -IQVKEAKDKESADGT------------TSSSGIGEPQQQPTPPSTFSRYSEATA--------PP 284
             :..||..|:.|:.|:            ::..|:||..:    |....|.||::.        ..
  Rat   191 KVNDKEVSDRISSLGSQAMQMERKKSQQSAGQGLGEAPR----PHYRGRSSESSCGLDGDYEDAE 251

  Fly   285 LSPS-LTSYAAHVEAKKKMPPRPPPKNIRRVEPPTIPSQQLSSSPKRETYMINTMPSSSSGSLCI 348
            |:|. |.....:.....: ||.||                |...|.:..|:         |.:.:
  Rat   252 LNPRFLKDNLINANGGNR-PPWPP----------------LEYQPYQSIYV---------GGMMV 290

  Fly   349 DSLGNSLERNIKPSDILRQKSSDNLDSKYSAKRKT-------------TPELSKFVNVNNPELME 400
            :..|.        |.:||.:|:...:.:.:..|::             ||:.|...|:.:.|  |
  Rat   291 EGEGK--------SPLLRSQSTSEQEKRLTWPRRSYSPRSFEDSGGGYTPDCSSNENLTSSE--E 345

  Fly   401 ELGRKMVSKADSLEQT----RRNDSSPSGCGSLGRTSSTPGRSLTPGRTGVGASPTGSLSKTGKL 461
            :......|:......|    |....|||........||:|              ||....|    
  Rat   346 DFSSGQSSRVSPSPTTYRMFRDKSRSPSQNSQQSFDSSSP--------------PTPQCQK---- 392

  Fly   462 AMADSSSTSSLERRSCLQAVDADIGTESRESGANQRSVGSKESLTSQGISEVQIKSYESVSSLSS 526
                       ..|.|...|........|::|....|.|..   |.||         |:.||..:
  Rat   393 -----------RHRQCQVVVSEATIVGVRKTGQIWPSDGDS---TFQG---------EADSSFGT 434

  Fly   527 ESAKAVASQQSAAAGGALAECEPYYDSVPLDNGDGEYVFIKPGRTGSSSSRDDLSTPGSSILPLP 591
            ......|:.|:       .|...:.|.:|       |:      ..|.||...||:.|.. .|..
  Rat   435 PPGYGCAADQA-------EEQRRHQDGLP-------YI------DDSPSSSPHLSSKGRG-SPAS 478

  Fly   592 NVADPESPGRTSNYVNIDFFLQQGIETRSSSLDSDGEYEGPPILRTISHDDQTTTQTTPGAIRKN 656
            ...:|                     |::|.||.:                              
  Rat   479 GALEP---------------------TKASELDLE------------------------------ 492

  Fly   657 LVSAILVCGNARGAKIRS-ILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIF 720
                       :|.::|. :||.|:.||..|:..|..::...|.:.|..||||||:..::..|||
  Rat   493 -----------KGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIF 546

  Fly   721 FKIDELYDLHTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANN 785
            ||:.|||::|..|...|...|........:|:.|::||....:|.||:.||..|:||.:||...|
  Rat   547 FKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMETAEKCCQAN 611

  Fly   786 PQFKKIVSTIVL--NLQTEQSLT---LEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQA 845
            .||.:|...:..  |...:.|.|   ||.||:|||.||..:.||.:|||:.||::||||..|:.|
  Rat   612 AQFAEISENLRARSNKDVKDSTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPSSHPDHSLLQDA 676

  Fly   846 QKIIQMFLNQFNVV----NQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKY- 905
            .:|.|.||:..|..    .|.:.::...: |:::::||:||||:|.|||||:|||.|::.|.|. 
  Rat   677 LRISQNFLSSINEEITPRRQSMTVKKGEH-RQLLKDSFMVELVEGARKLRHIFLFTDLLLCTKLK 740

  Fly   906 KALGRDRIDYELKWFIPLKDVSIY----------------EEADPAVELKESSPANISQVKRNLR 954
            |..|.....|:.||:|||.|:|..                ||.| |:::|      |||:|.:::
  Rat   741 KQSGGKTQQYDCKWYIPLTDLSFQMVDELEALPNIPLVPDEELD-ALKIK------ISQIKSDIQ 798

  Fly   955 SVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFER 1019
            ..:.      ||.||...   ::.|:||::.||.|:|.:|::..|:.:: |.|:.||.:|||:||
  Rat   799 REKR------ANKGSKVM---ERLRKKLSEQESLLLLMSPSMAFRVHSR-NGKSYTFLISSDYER 853

  Fly  1020 TQWIDSILSLKQKCNLPGANTINSLEVTAFIVAM--QKGMKTEMGSYL---MRNTNDESL-LVGD 1078
            .:|.:||...::||       ..|..:|:..:.|  ...:|.:...::   :...:|||. |.|.
  Rat   854 AEWRESIREQQKKC-------FKSFSLTSVELQMLTNSCVKLQTVHHIPLTINKEDDESPGLYGF 911

  Fly  1079 LYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLY 1143
            |:..||...|.:|:::||..:||||:|::..||.|:....:..|.|||.|.:||||||.:|||.|
  Rat   912 LHAIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTTEPNWNEEFEIELEGSQTLRILCY 976

  Fly  1144 E--------AKE----RPLLKAKHILKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGELF--- 1193
            |        |||    ...|..|..::|....|.:....:::.....:|:..|.:|...|..   
  Rat   977 EKCYNKMKMAKEDGESADKLMGKGQVQLDPQTLQDRDWQRTVIDMNGIEVKLSVKFTSREFSLKR 1041

  Fly  1194 RGSTKPGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFES 1258
            ..|.|...:||.|::.|.|||:..:|:|:..|:.|:|||||.|||.|||||.|:|:..||.||:.
  Rat  1042 MPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDV 1106

  Fly  1259 DAYEAEQLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSN--NNESTRINELLKV 1321
            :..:...::.|:|::::.|.||.:.|||||.||||:.||.|.:.. |.|:  ..||..:|.||  
  Rat  1107 NNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGI-ALSDPVAKESCMLNLLL-- 1168

  Fly  1322 FEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVK----QKDPLAAS 1382
              .||:||..:...:||||.||.||||.|||||||||.|||||||||.:.:.|    ...|:..:
  Rat  1169 --SLPEANLLTFLFLLDHLKRVAEKETVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMT 1231

  Fly  1383 ---TVDVMAQAGILYCFLQ 1398
               :::||:|..:|..|||
  Rat  1232 DSWSLEVMSQVQVLLYFLQ 1250

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP1ANP_001284725.1 RhoGEF 675..857 CDD:214619 74/186 (40%)
PH_BCR_arthropod 851..1037 CDD:270174 69/206 (33%)
C2 1079..1187 CDD:301316 40/119 (34%)
RhoGAP 1203..1398 CDD:295372 93/203 (46%)
BcrXP_038955099.1 Bcr-Abl_Oligo 3..75 CDD:401106 21/72 (29%)
RhoGEF 501..688 CDD:395496 74/186 (40%)
PH-like 683..876 CDD:418428 71/217 (33%)
C2_ABR 912..1032 CDD:176068 40/119 (34%)
RhoGAP_Bcr 1051..1251 CDD:239852 95/205 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166353448
Domainoid 1 1.000 148 1.000 Domainoid score I4344
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 439 1.000 Inparanoid score I1620
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D332603at33208
OrthoFinder 1 1.000 - - FOG0002220
OrthoInspector 1 1.000 - - otm45157
orthoMCL 1 0.900 - - OOG6_104879
Panther 1 1.100 - - O PTHR23182
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2211
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.900

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