DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and Arhgap27

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_942054.1	Gene:	Arhgap27 / 303583	RGDID:	735202	Length:	869	Species:	Rattus norvegicus

Alignment Length:	1128	Identity:	231/1128 - (20%)
Similarity:	362/1128 - (32%)	Gaps:	404/1128 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 YAAHVEAKKKMPPRPPPKNIRRVEPPTIPSQQLSSSPKRETYMINTMPSSSSGSLCIDSLGNSLE 356
            |...:.|.....|.|.|..::  :.||:|      .|....|...:.|..:.||        |.|
  Rat    63 YVRELPALGDPVPAPQPSVLQ--QRPTVP------EPLAYDYRFVSTPVGADGS--------SAE 111

  Fly   357 RNIKPSDI---LRQKSSDNLDSKYSAKRKTTPELSKFVNVNNPELMEELGRKMVSKADSLEQTRR 418
            ...:.|.:   .||::|...:|               :....|..:.......|..|.||:...|
  Rat   112 PRGRASSLCGPARQRTSGQRNS---------------LAPGGPACLYLRPAAPVRPAQSLDDLAR 161

  Fly   419 NDSSPSG--CGSLG--RTSSTPGRSLTPGRTGVGASPTGSLSKTGKLAMADSSSTSSLERRSCLQ 479
            ..::|..  .||.|  :.||..|..:.|                ..||.:||.:.        .:
  Rat   162 GGTAPPAGLLGSAGHFKASSVAGSWVCP----------------RPLARSDSENV--------YE 202

  Fly   480 AVDADIGTESRESGANQRSVGSKESLTSQGISEVQIKSYESVSSLSSESAKAVASQQSAAAGGAL 544
            |: .|:....|.....|             :.|.....|.:|     |....|.|.:||||...|
  Rat   203 AI-PDLRCPPRAKSPKQ-------------VDEPPEPVYANV-----ERQPQVTSPRSAAAPPRL 248

  Fly   545 AECEPYYDSVPLDNGDGEYVFIKPGRTGSSSSRDDLSTPGSSILPLPNVA--------------- 594
            :   |.::: ..|.|.|...:..|. ||.::.......|..:..|..:.|
  Rat   249 S---PVWET-HTDAGTGRPYYYNPD-TGVTTWESPFEAPEGATSPTTSRASVGSGESLETEWGQY 308

  Fly   595 -DPESPGRTSNYVNIDFFLQQGIETRSSSLDSDGEYEGPPILRTISHDDQTTTQTTPGAIRKNLV 658
             |.|| ||...|..:........||.....|.:.:.|..|.|...|...|  ...||
  Rat   309 WDEES-GRVFFYNPLTGETVWEDETEELEDDPEEQLEMQPSLSPRSPGQQ--RPPTP-------- 362

  Fly   659 SAILVCGNARGAKIRSILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKI 723
                                    ||.|.|               |.||.|   ||:.:.:
  Rat   363 ------------------------ETDYPE---------------LLTSYP---EEDYSPV---- 381

  Fly   724 DELYDLHTGFLSDL---KTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANN 785
                    |..|||   ..:|:..|....|                          |.:|.....
  Rat   382 --------GSFSDLGPTSPLVAPPGWSCQI--------------------------TPEKQMLYT 412

  Fly   786 PQFKKIVSTIVLNLQTEQSLTLEDLLHKPVARVQINALVFNDLLR----------------ETP- 833
            .||.:           ||.:.|||...||......::.|..:|.:                :||
  Rat   413 NQFTQ-----------EQWVRLEDQEGKPYFYNPEDSSVQWELPQVPVPAPRSGRKSSQDSDTPA 466

  Fly   834 NAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFND 898
            .|.|..:.::.        |::..|:::...::..:.||:...|:....|..|     .|..|.|
  Rat   467 QASPPEEKIKT--------LDKAGVLHRTKTVDKGKRLRKKHWNASWTVLEGG-----VLTFFKD 518

  Fly   899 VIACAKYKALGRDRIDYELKWFIPLKDVSIYEEADPAVELKESS----PANISQVKRNLRSVRDQ 959
            ....|   |.|             |:..|.....:..|||:.:|    |.:.|. |:|:..:|.
  Rat   519 SKTSA---ASG-------------LRQPSKLSTPEYTVELRGASLSWAPKDKSS-KKNVLELRS- 565

  Fly   960 LAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWID 1024
                         |.|.:|   |...:|:.:::|.:..:..|.:.        ||:|..:.:..:
  Rat   566 -------------RDGSEY---LIQHDSEAIISTWHKAIAEGIEE--------LSADLPQREEGE 606

  Fly  1025 SILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDLYMGVHGLEGL 1089
                       |.:....|.|              .:||:...:...
  Rat   607 -----------PSSADFGSSE--------------RLGSWKEEDVRP------------------ 628

  Fly  1090 EQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAKERPLLKAK 1154
                                        .:.:|..|       .|||          |..|.:.:
  Rat   629 ----------------------------NAASPSLN-------PGSQ----------ESDLSRVR 648

  Fly  1155 HILKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGELFRGSTKPGALFGAKMSQVLKREKRDIP 1219
            |.|:            |.::...||:   |.|      .:|..| ..:||..::|:.:||:..:|
  Rat   649 HKLR------------KFLQRRPTLQ---SLR------EKGYIK-DQVFGCALAQLCERERSPVP 691

  Fly  1220 FIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQL----LREVDIHSVTGILK 1280
            ..:..|||.||.||:...|.||:||:.:.:.||:...:.|    |:|    .|..|:|.:||.||
  Rat   692 RFVQQCIRTVEARGLDIDGLYRISGNLATIQKLRYKVDHD----ERLDLDDGRWEDVHVITGALK 752

  Fly  1281 TFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHE 1345
            .|.|||||.||....:.:|............|..:.:|::.   ||..|..::..::.||.||.|
  Rat   753 LFFRELPEPLFPFSHFHQFIAAIKLQDPAQRSRCVRDLVRT---LPAPNHDTLRLLIQHLCRVIE 814

  Fly  1346 KETDNKMSLHNLAMVFGPTLLRP 1368
            ....|:||:.|:|:|||||||||
  Rat   815 HGEQNRMSVQNVAIVFGPTLLRP 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	35/201 (17%)
		PH_BCR_arthropod	851..1037	CDD:270174	34/189 (18%)
		C2	1079..1187	CDD:301316	13/107 (12%)
		RhoGAP	1203..1398	CDD:295372	63/170 (37%)
Arhgap27	NP_942054.1	SH3	10..66	CDD:302595	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..137		9/55 (16%)
		WW	248..278	CDD:278809	8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..299		3/23 (13%)
		WW	301..328	CDD:278809	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..389		24/121 (20%)
		WW	418..445	CDD:278809	8/26 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..474		4/26 (15%)
		PH_ARHGAP9-like	480..594	CDD:270053	30/152 (20%)
		PH	480..593	CDD:278594	30/151 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..644		12/133 (9%)
		RhoGAP_ARHGAP27_15_12_9	675..861	CDD:239868	63/170 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810