DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and ABR

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	XP_016880028.1	Gene:	ABR / 29	HGNCID:	81	Length:	1137	Species:	Homo sapiens

Alignment Length:	1119	Identity:	339/1119 - (30%)
Similarity:	548/1119 - (48%)	Gaps:	184/1119 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 DSLEQTRRNDSSPSGCGSLGRTSSTPGRSLTPGRTGVGASPTGSLSKTGKLAMADSSSTSSLERR 475
            ||.|..|.:..:.|..|..||    |.......|..:.|.|..:....|..:.||:.....|:.:
Human    70 DSGEPGRPDPEAESPRGDPGR----PDPEAESPRGDLPAGPGAAGEAGGGRSWADAVHRQLLQPQ 130

  Fly   476 SCLQA--VDADIGTESRESGANQRSVGSKESLTSQGISEVQIKSYESVSSL---SSESAKAVASQ 535
            ...:|  .||.:|......|.::...|..........:|..|.|:..|:..   :.|.|::....
Human   131 LRFRAREDDAPLGDPQAAPGTDEGGDGGDHDFEMVDFNEKFILSHWLVAPCRFGTRERARSPRRW 195

  Fly   536 QSAAAGGALAECEPYYDSVPLDNGDGEYVFIKPGRTGSSSSRDDLSTPGSSILP------LPNVA 594
            .....||.    .|...:..|:..:.|    ..||.||..:.::  |||...||      ...|.
Human   196 MHLIPGGR----RPQRGTRDLEQREAE----AKGRPGSPLAAEE--TPGREHLPPWRRRRFLRVP 250

  Fly   595 DPESPGRTSNYVNIDFFLQQGIETRSSS----------------LDSDG--EYEGPPI-LRTISH 640
            :.:|||.:|...:.|       .:|.||                .|.:|  |.:|||. ..|:.:
Human   251 ERDSPGHSSPERDSD-------GSRHSSDREDDFSADFSYGTDEYDGEGNEEQKGPPEGSETMPY 308

  Fly   641 DDQTTTQ-----------------TTPGAIRKNLVSAILVCGNARGAKIRS-ILSSIIQSETIYV 687
            .|::.|.                 |.|..:...:.:       .:|.::|. :||..:.||.||:
Human   309 IDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEA-------GKGLEMRKLVLSGFLASEEIYI 366

  Fly   688 ECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLSDLKTIVSHEGGDVLIGE 752
            ..|..::...|.:.||.||||||:..::..|||:||.::|::|..|..:|...|......|.:|.
Human   367 NQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGH 431

  Fly   753 PFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVL-----NLQTEQSLTLEDLLH 812
            .|::||....:|.||:.|||.|:||.:|||.:|.||:||...:.:     :..:..|:|:|.||:
Human   432 LFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLY 496

  Fly   813 KPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFN--VVNQRLPIESNR-NLRRM 874
            ||:.||..:.||.:|||:.||..|||:..|:.|.:|.|.||:..|  :..:|..:.:.: ..|::
Human   497 KPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQL 561

  Fly   875 VRNSFIVELVDGHRKLRHLFLFNDVIACAKYK--ALGRDRIDYELKWFIPLKDVSIYEEADPAVE 937
            |::.|:||:.:..|||||:|||.||:.|||.|  :.|:.: .|:.||:|||.|:..     |:.|
Human   562 VKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQ-QYDCKWYIPLADLVF-----PSPE 620

  Fly   938 LKESSPA-------NISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPN 995
            ..|:||.       .:..:|..:.:::.::..|.||.|..  |:.::.::|:.:.|..|:|.:|.
Human   621 ESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQS--RAIERLKKKMFENEFLLLLNSPT 683

  Fly   996 LVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTE 1060
            :..|:.|: |.|:..|.||||:||::|.::|..|::|            ::.||:::..: ::..
Human   684 IPFRIHNR-NGKSYLFLLSSDYERSEWREAIQKLQKK------------DLQAFVLSSVE-LQVL 734

  Fly  1061 MGSYLMRNT-----------NDESL-LVGDLYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATT 1113
            .||.....|           :|||. |.|.|::.||..:|.:|:.:||..:||||:|::..||.|
Human   735 TGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKT 799

  Fly  1114 KKICRSQTPLWNESFMLELEGSQNVRILLYEA--------KERPLLKAKHILKLSL--------- 1161
            :....:..|.|:|.|.:||||||::|||.||.        |:...:..|.:.|..:
Human   800 RVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVET 864

  Fly  1162 -SWLTETTQPKSIKLTETLEL---GCSFRFIPGELFRGSTKPGALFGAKMSQVLKREKRDIPFII 1222
             :|.|:..:...||:..:::.   ..|.:..|      |.|...:||.|:|.|.|||:..:|:|:
Human   865 KNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTP------SKKQTGVFGVKISVVTKRERSKVPYIV 923

  Fly  1223 GACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESD-----------------AYEAEQL--LR 1268
            ..|:.|||:||:.|||.||:||.|:|:..||..|::.                 .|..:.|  |.
Human   924 RQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDASKQLQKLTRADSLAQDDPTYNKDILLMLS 988

  Fly  1269 EVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASI 1333
            ::||:::.|.||.:.|||||.|.||:|||.|.:   ..:.::.:.:.|.::.:...||..|..:.
Human   989 DMDINAIAGTLKLYFRELPEPLLTDRLYPAFME---GIALSDPAAKENCMMHLLRSLPDPNLITF 1050

  Fly  1334 TSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVKQKDPLAAS--TVDVMAQAGILYCF 1396
            ..:|:||.||.|||..|||||||||.|||||||||.:.:.|.....||.  :.|||||..:|..:
Human  1051 LFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYY 1115

  Fly  1397 LQ------ARIKKD 1404
            ||      |.:|::
Human  1116 LQHPPISFAELKRN 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	73/186 (39%)
		PH_BCR_arthropod	851..1037	CDD:270174	62/197 (31%)
		C2	1079..1187	CDD:301316	38/128 (30%)
		RhoGAP	1203..1398	CDD:295372	87/215 (40%)
ABR	XP_016880028.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159416
Domainoid	1	1.000	146	1.000	Domainoid score	I4551
eggNOG	1	0.900	-	-		E1_KOG4269
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11081
Inparanoid	1	1.050	461	1.000	Inparanoid score	I1565
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	1	1.000	-	-		FOG0002220
OrthoInspector	1	1.000	-	-		otm41021
orthoMCL	1	0.900	-	-		OOG6_104879
Panther	1	1.100	-	-	LDO	PTHR23182
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	1	1.000	-	-		X2211
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790