DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP1A and Abr

DIOPT Version :9

Sequence 1:NP_001284725.1 Gene:RhoGAP1A / 5740235 FlyBaseID:FBgn0025836 Length:1404 Species:Drosophila melanogaster
Sequence 2:XP_038941451.1 Gene:Abr / 287537 RGDID:1306279 Length:1185 Species:Rattus norvegicus


Alignment Length:1495 Identity:398/1495 - (26%)
Similarity:621/1495 - (41%) Gaps:419/1495 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 DFQRLWMQRFPQS-----SLSDAWEQDVRASLERHKVRINELSKELEQETLYVEYLERLLS---- 61
            :|:|.|...||..     .|...  .|:...|||.|:.:..|.:.|.:|...|.||:..|:    
  Rat     6 EFERHWQAEFPGEEAPVMKLESV--PDMERELERCKLNLKRLQQVLAEEKFKVWYLQAALAGERM 68

  Fly    62 DVERYRVSGGDPKALFEAASGSCASSNNSNCSSTTNGATQEESNTNLDKDFKSSLNLRESPSSTG 126
            |:.|....|||        .|.|.|...|      .||:.||                :.|:   
  Rat    69 DLPRGPPEGGD--------GGGCGSGTGS------RGASVEE----------------QEPA--- 100

  Fly   127 AKDKDRLSLNPDNKYTTHTNAVIGGIGSEKVSGPLHSTQITADGKRTGELYLKREEDKCKDSNSE 191
                                   |.:    .:.|.|:                :|....:||:|.
  Rat   101 -----------------------GAV----CAPPPHN----------------KEGASSRDSDSP 122

  Fly   192 -----DTDGALQ------QCITELAASLKAQPDNVAGGRLENDVDIDKPLRKSTSQYVTVIQVKE 245
                 |::.|..      .|:     .|.|.|..|.||         ..:|..|:..        
  Rat   123 GPTLLDSEVATSAEPSPFMCL-----DLPAWPGAVEGG---------GAVRSLTAAI-------- 165

  Fly   246 AKDKESADGTTSSSGIGEPQQQPTPPSTFSRYSEATAPPLSPSLTSYAAHVEAKKKMPPRPPPKN 310
                               .||...|....|..|...|| :|..|.                   
  Rat   166 -------------------HQQLVQPRLLFRLREDCVPP-APDGTG------------------- 191

  Fly   311 IRRVEPPTIPSQQLSSSPKRETYMINTMPSSSSGSLCIDSLGNSLERNIKPSDILRQKSSDNLDS 375
                  ..||..|.||..:.........|.:|.|    |..|:..:.:.:..|         |:.
  Rat   192 ------SPIPGDQRSSETRAGRGSEEGEPDASGG----DDGGDCSDHDFEIVD---------LNE 237

  Fly   376 KY--------SAKRKTTPELSKFVNVNNP----ELMEELGRKMVSKADSLEQTRRNDSSPSGCGS 428
            |:        ..:..|..|..|.....:|    .|:....|....::..|||....|.||     
  Rat   238 KFVLGHLLMAPCRFGTRDEAEKPARPCSPHRWMHLISGGWRHHRRRSRDLEQLEAEDESP----- 297

  Fly   429 LGRTSSTPGRSLTPGRTGVGASPTGSLSKTG-----KLAMADSSSTSSLERRSCLQAVDADIGTE 488
                           |.|.    ...|::.|     ::...||.|.||.||.|     |....:.
  Rat   298 ---------------RRGA----REHLAQWGRKRFLRVPDRDSPSHSSPERGS-----DCSHNSS 338

  Fly   489 SRESGANQRSVGSKESLTSQGISEVQIKSYESVSSLSSESAKAVASQQSAAAGGALAECEPYYDS 553
            ..|.|.:.......|...::|..|                      |:....|   :|..||.|.
  Rat   339 DHEDGFSADFSYGAEDYDAEGHEE----------------------QKGPPEG---SETMPYIDE 378

  Fly   554 VPLDNGDGEYVFIKPGRTGSSSSRDDLSTPGSSILPLPNVADPESPGRTSNYVNIDFFLQQGIET 618
            .|.         :.|..:..|..      .|.||.|.|    ||.             |..|:|.
  Rat   379 SPT---------MSPQLSARSQG------GGESISPTP----PEG-------------LAPGVEA 411

  Fly   619 RSSSLDSDGEYEGPPILRTISHDDQTTTQTTPGAIRKNLVSAILVCGNARGAKIRS-ILSSIIQS 682
                                                            .:|.::|. :||..:.|
  Rat   412 ------------------------------------------------GKGLEMRKLVLSGFLAS 428

  Fly   683 ETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLSDLKTIVSHEGGD 747
            |.||:..|..::...|.:.||.||||||:..::..|||:||.::|::|..|..:|...|......
  Rat   429 EEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQ 493

  Fly   748 VLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVL-----NLQTEQSLTL 807
            |.:|..|::||....:|.||:.|||.|:||.:|||.:|.||:||...:.:     :..:..|:|:
  Rat   494 VTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTM 558

  Fly   808 EDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFN--VVNQRLPIESNR- 869
            |.||:||:.||..:.||.:|||:.||..|||:..|:.|.:|.|.||:..|  :..:|..:.:.: 
  Rat   559 EALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKG 623

  Fly   870 NLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYK--ALGRDRIDYELKWFIPLKDVSIYEEA 932
            ..|::|::.|:||:.:..|||||:|||.||:.|||.|  :.|:.: .|:.||:|||.|:..    
  Rat   624 ETRQLVKDGFLVEMSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQ-QYDCKWYIPLADLVF---- 683

  Fly   933 DPAVELKESSPA-------NISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLV 990
             |:.|..|:||.       .:..:|..:.:::.::..|.||.|..  |:.::.::|:.:.|..|:
  Rat   684 -PSPEESEASPQVHPFPDHELEDMKVKISALKSEIQKEKANKGQS--RAIERLKKKMFENEFLLL 745

  Fly   991 LATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQK 1055
            |.:|.:..|:.|: |.|:..|.||||:||::|.::|..|::|            ::.||:::..:
  Rat   746 LNSPTIPFRIHNR-NGKSYLFLLSSDYERSEWREAIQKLQKK------------DLQAFVLSSVE 797

  Fly  1056 GMKTEMGSYLMRNT-----------NDESL-LVGDLYMGVHGLEGLEQANDLYICVEVDSYGHYF 1108
             ::...||.....|           :|||. |.|.|::.||..:|.:|:.:||..:||||:|::.
  Rat   798 -LQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFV 861

  Fly  1109 RKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEA--------KER----PLLKAKHILKL-- 1159
            .||.|:....:..|.|:|.|.:||||||::|||.||.        |:.    ..:..|..::|  
  Rat   862 SKAKTRVFRDTTEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDP 926

  Fly  1160 ----SLSWLTETTQPKSIKLTETLEL---GCSFRFIPGELFRGSTKPGALFGAKMSQVLKREKRD 1217
                |.:|.|:..:...||:..:::.   ..|.:..|      |.|...:||.|:|.|.|||:..
  Rat   927 QTVESKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTP------SKKQTGVFGVKISVVTKRERSK 985

  Fly  1218 IPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLLREVDIHSVTGILKTF 1282
            :|:|:..||.|||:||:.|||.||:||.|:|:..||..|:::..:...:|.::||:::.|.||.:
  Rat   986 VPYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLY 1050

  Fly  1283 LRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHEKE 1347
            .|||||.|.||:|||.|.:   ..:.::.:.:.|.::.:...||..|..:...:|:||.||.|||
  Rat  1051 FRELPEPLLTDRLYPAFME---GIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKE 1112

  Fly  1348 TDNKMSLHNLAMVFGPTLLRPGQTQVKQKDPLAAS--TVDVMAQAGILYCFLQ------ARIKKD 1404
            ..|||||||||.|||||||||.:.:.|.....||.  :.|||||..:|..:||      |.:|::
  Rat  1113 PINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRN 1177

  Fly  1405  1404
              Rat  1178  1177

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP1ANP_001284725.1 RhoGEF 675..857 CDD:214619 73/186 (39%)
PH_BCR_arthropod 851..1037 CDD:270174 62/197 (31%)
C2 1079..1187 CDD:301316 39/128 (30%)
RhoGAP 1203..1398 CDD:295372 86/196 (44%)
AbrXP_038941451.1 Bcr-Abl_Oligo 3..67 CDD:401106 18/62 (29%)
RhoGEF 418..608 CDD:238091 74/189 (39%)
PH_ABR 603..786 CDD:270172 61/191 (32%)
C2_ABR 832..952 CDD:176068 38/119 (32%)
RhoGAP_Bcr 971..1166 CDD:239852 87/197 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166353449
Domainoid 1 1.000 148 1.000 Domainoid score I4344
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H11081
Inparanoid 1 1.050 439 1.000 Inparanoid score I1620
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D332603at33208
OrthoFinder 1 1.000 - - FOG0002220
OrthoInspector 1 1.000 - - otm45157
orthoMCL 1 0.900 - - OOG6_104879
Panther 1 1.100 - - LDO PTHR23182
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2211
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.900

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