DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and rga7

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_595866.1	Gene:	rga7 / 2540635	PomBaseID:	SPBC23G7.08c	Length:	695	Species:	Schizosaccharomyces pombe

Alignment Length:	881	Identity:	177/881 - (20%)
Similarity:	306/881 - (34%)	Gaps:	257/881 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   580 LSTPGSSILPLPNVADPESPGRTSNYVNIDFFLQQGIETRSSSLDSDGEYEGPPILRTISHDDQT 644
            ||.|.||..|   .:.|.||..|::..:.....:..:|   :.|:|:   .|..||.....|...
pombe     2 LSAPSSSTTP---ASPPTSPPNTTSSDDFAVLKEPKVE---AILNSE---LGLAILNDRIKDYLL 57

  Fly   645 TTQTTPGAIRK-------------NLVSAILVCGNARGAKIRSILSSIIQSETIYVECLNKMMQY 696
            |.:...|..:|             .|..:.|....::....:|..:|:|.|..|:.:..|..:..
pombe    58 TCKELAGFFKKRSILEEESGKNLQKLAKSYLETFQSKHHSPQSFSASVITSMEIHEQLANHSLTL 122

  Fly   697 KKAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMF 761
            :|.:.|                  |. |::.:.|.......|:|
pombe   123 QKTLSA------------------FS-DQVIEFHKNAERKRKSI--------------------- 147

  Fly   762 DLYSAFLHNYKNA-IETVKKCSANNPQFKKIVSTIVLNLQTEQSLTLEDL----------LHKPV 815
               ..:....:|| :|.|.:...:..:||        ..:||.:..|::.          ..||.
pombe   148 ---KEYAKKQENAYLEAVMQMDKSKSRFK--------GAETEYNRALDNKNTGDSQKKVGFFKPK 201

  Fly   816 ARVQINALVFNDLLR-ETPNAHPD-HQPLRQAQKIIQMFL--NQFNVVNQRLPIESNRNLRRMVR 876
            :..|:..|  .|..| :..||..| |..:..||.:.:..|  ::.|.:.|..      :|:|.:.
pombe   202 SNAQLTKL--EDEARLKAENAESDMHSKIENAQNVQKQLLCIHRPNYIKQFF------SLQREIE 258

  Fly   877 NSFIVELVDGHRKLRHLFLFNDVIA---------CAKYKAL-----GRDRIDYELKWFIPLKDVS 927
            :|.|...:...:......|.|.:..         |....||     ..|.:.|.|...|..:|
pombe   259 SSLIANYLRYTKLCESNTLLNGLTIRPQKPTPTNCGLQHALDNINANTDFVQYVLHASIKHED-- 321

  Fly   928 IYEEADPAVELKESSPANISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLVLA 992
                        ..:|.:.|:.|         :....::.|:|:  |..|
pombe   322 ------------NKNPTDASKTK---------IIQPPSSYGTGS--SAGK--------------- 348

  Fly   993 TPNLVLRLGNKANNKTI--TFFLSSDFERTQWIDSILSLKQKCN--LPGANTINSLEVTAFIVAM 1053
                    .|...|.||  |..:.|..:.|....|........:  .|.::|.|.....|....:
pombe   349 --------TNPPVNPTIKVTAAIPSPLQNTNPAPSTFPNPSVASPAFPNSSTSNPSTAPASASPL 405

  Fly  1054 QKGMKTEMGSYLMRNTNDESLLVGDLYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICR 1118
            ...:|....:    :||..|                                     :::....|
pombe   406 ASTLKPSTAN----DTNGSS-------------------------------------SSSSSNPR 429

  Fly  1119 SQTPLWNESFMLELEGSQNVRILLYEAKERPLLKAKHILKLSLSWLTETT---------QPKSIK 1174
            :.:||.:.:                |.|.....::..:|..:|..:..||         .|.||.
pombe   430 TSSPLASNA----------------ENKPPVAQQSPPVLLPTLPPIQTTTIQTSREVAPPPSSIN 478

  Fly  1175 LTETLELGCSFRFIPGELFRGSTKP--GALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEV 1237
            ...     .:..|.|..:....:.|  ..||||::..::.||..:||.|:..|..:||..|:...
pombe   479 SNR-----AASPFRPTSVSPQPSSPTKSLLFGARLDAIILREHSNIPNIVMQCTSQVENFGLNLQ 538

  Fly  1238 GCYRVSGSASDLAKLKKAFESDAYEAEQLLR-------EVDIHSVTGILKTFLRELPEALFTDQL 1295
            |.|||..|::.:..|:..||::     .||:       |.|:|:|..:||.|.|||.|.|..|..
pombe   539 GIYRVPSSSARVNMLRSQFENN-----PLLQLHTPEDYENDVHAVADLLKIFFRELREPLIPDNH 598

  Fly  1296 YPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMV 1360
            ...|.|   |.:..:||.|.:.:.:...:||.||.::|..:..||.::.|....||||.:|||::
pombe   599 QRDFID---AGNVEDESRRRDAVHRAINDLPDANYSTIRHLTIHLAKIKENSDVNKMSTNNLAII 660

  Fly  1361 FGPTLLRPGQTQVKQKDPLAASTVDVMAQAGILYCF 1396
            :|||:::  |..:.:.... :.|::::    |.|||
pombe   661 WGPTIIK--QATIPEISSF-SRTIEIL----IDYCF 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	34/196 (17%)
		PH_BCR_arthropod	851..1037	CDD:270174	32/205 (16%)
		C2	1079..1187	CDD:301316	12/116 (10%)
		RhoGAP	1203..1398	CDD:295372	65/201 (32%)
rga7	NP_595866.1	F-BAR_Rgd1	39..277	CDD:153336	52/299 (17%)
		PRR18	335..>406	CDD:292299	16/95 (17%)
		RhoGAP_fRGD1	504..692	CDD:239863	65/201 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I1426
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.990