DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP1A and Arhgap9

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_001272714.1	Gene:	Arhgap9 / 216445	MGIID:	2143764	Length:	648	Species:	Mus musculus

Alignment Length:	197	Identity:	68/197 - (34%)
Similarity:	101/197 - (51%)	Gaps:	26/197 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1192 LFRGSTKPGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLK--- 1253
            |||..     :||.::..:.:||...:|..:..|:..|:::|:...|.|||||:.:.:.||:
Mouse   432 LFRDQ-----VFGCQLESLCQREGDTVPSFVRLCVEAVDKKGLDVDGIYRVSGNLAVVQKLRFLV 491

  Fly  1254 ---KAFESDA--YEAEQLLRE----------VDIHSVTGILKTFLRELPEALFTDQLYPRFFDTF 1303
               :|..||.  ...||..:|          .|||.|||.||.|.||||:.|....|.|.|.|
Mouse   492 DRERAVTSDGRYMFPEQAGQEGKLDLDSAEWDDIHVVTGALKLFFRELPQPLVPALLLPDFRD-- 554

  Fly  1304 SAFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRP 1368
             |...:.....::::.|:.:.||:.|..::..||:||.||......|:|:.|||.:||||||.||
Mouse   555 -ALELSEPEQCLSKIQKLIDSLPRPNHDTLKYILEHLCRVIAHSDKNRMTAHNLGIVFGPTLFRP 618

  Fly  1369 GQ 1370
            .|
Mouse   619 EQ 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619
		PH_BCR_arthropod	851..1037	CDD:270174
		C2	1079..1187	CDD:301316
		RhoGAP	1203..1398	CDD:295372	65/186 (35%)
Arhgap9	NP_001272714.1	SH3	26..82	CDD:302595
		PH_ARHGAP9-like	236..349	CDD:270053
		PH	250..348	CDD:278594
		ASCH	<346..432	CDD:294653	68/197 (35%)
		RhoGAP_ARHGAP27_15_12_9	438..642	CDD:239868	65/186 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940