DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP1A and ARHGAP27

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	XP_011522770.1	Gene:	ARHGAP27 / 201176	HGNCID:	31813	Length:	922	Species:	Homo sapiens

Alignment Length:	978	Identity:	202/978 - (20%)
Similarity:	323/978 - (33%)	Gaps:	336/978 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 SSLSSESAKAVASQQSAAAGGALAECEPYYDSVPL----DNGDGEYVFIKP--GRTGSSSSRDDL 580
            |||...:.:..|:|:|:.|.| |..|.....:.|:    ...|.....:.|  |..|||.|....
Human   118 SSLCGPAQRGAATQRSSLAPG-LPACLYLRPAAPVRPAQSLNDLACAAVSPPAGLLGSSGSFKAC 181

  Fly   581 STPGSSILPLP--------------------------NVADPESPGRTSNYVNIDFFLQQGIETR 619
            |..||.:.|.|                          .|.||..|    .|.||:         |
Human   182 SVAGSWVCPRPLARSDSENVYEVIQDLHVPPPEESAEQVDDPPEP----VYANIE---------R 233

  Fly   620 SSSLDSDGEYEGP---PILRT-----------ISHDDQTTTQTTPGAIRKNLVSAILVCGNARGA 670
            .....|.|....|   |:..|           .:.|...||..:|...             |.||
Human   234 QPRATSPGAAAAPLPSPVWETHTDAGTGRPYYYNPDTGVTTWESPFEA-------------AEGA 285

  Fly   671 KIRSILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLS 735
            ...:...:.:.|                  |.:|.|......:||...:||     |:..||
Human   286 ASPATSPASVDS------------------HVSLETEWGQYWDEESRRVFF-----YNPLTG--- 324

  Fly   736 DLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNLQ 800
              :|....|..:    ||                  :..:|.....|..:|...:..:.     :
Human   325 --ETAWEDEAEN----EP------------------EEELEMQPGLSPGSPGDPRPPTP-----E 360

  Fly   801 TE--QSLTL---EDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVN 860
            |:  :|||.   ||  :.||..       |.:....:|...|.......:|....::.|.|.
Human   361 TDYPESLTSYPEED--YSPVGS-------FGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFT--- 413

  Fly   861 QRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKD 925
                            ....|.|.|.|.|   .:.:|..              |..::|.:|...
Human   414 ----------------QEQWVRLEDPHGK---PYFYNPE--------------DSSVRWELPQVP 445

  Fly   926 V----SIYEEADPAVELKESSPANISQVKRNLRSVRDQL-AMEVANSGSGAFR------SGDKYR 979
            |    ||::.:...     .:||..|..:..:.:..|:: :.|..:..:.|.|      :|..:|
Human   446 VPAPRSIHKSSQDG-----DTPAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHR 505

  Fly   980 RKLADLESQLVLATPNLVLRLGNKANNK------------TITFFLS------------SDFERT 1020
            .|.||               .|.:...|            .:|||..            |.|...
Human   506 TKTAD---------------KGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTP 555

  Fly  1021 QWIDSILSL------KQKCNLPGANTINSLEVTAFIV-------------AMQKGMKTEMGSYLM 1066
            ::...:...      |.|.:......:.|.:.:.:::             |:.:|:: |:||..:
Human   556 EYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQ-ELGSMQL 619

  Fly  1067 RNTNDESLLVGDLYMG----VHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNES 1127
            |..|...|..|....|    :....|::.|                          ...|..:||
Human   620 REVNVLRLTGGGPAAGSRPRLSEAMGIQSA--------------------------ELPPEESES 658

  Fly  1128 FMLELEGSQNVRILLYEAKE---RP---------------LLKAKHILKLSLSWLTETTQPKSIK 1174
            ..::...|:  |:..::.||   ||               |.|.:|.|:            |.::
Human   659 SRVDFGSSE--RLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKLR------------KFLQ 709

  Fly  1175 LTETLELGCSFRFIPGELFRGSTKPGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGC 1239
            ...||:   |.|      .:|..| ..:||..::.:.:||:..:|..:..|||.||.||:...|.
Human   710 RRPTLQ---SLR------EKGYIK-DQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGL 764

  Fly  1240 YRVSGSASDLAKLKKAFESDAYEAEQL----LREVDIHSVTGILKTFLRELPEALFTDQLYPRFF 1300
            ||:||:.:.:.||:...:.|    |:|    .|..|:|.:||.||.|.|||||.||....:.:|.
Human   765 YRISGNLATIQKLRYKVDHD----ERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFI 825

  Fly  1301 DTFSAFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTL 1365
            ...........|..:.:|::   .||..|..::..:..||.||.|....|:||:.::|:||||||
Human   826 AAIKLQDQARRSRCVRDLVR---SLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTL 887

  Fly  1366 LRP 1368
            |||
Human   888 LRP 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	31/186 (17%)
		PH_BCR_arthropod	851..1037	CDD:270174	35/226 (15%)
		C2	1079..1187	CDD:301316	20/129 (16%)
		RhoGAP	1203..1398	CDD:295372	61/170 (36%)
ARHGAP27	XP_011522770.1	SH3_ARHGAP27	10..66	CDD:213002
		WW	247..278	CDD:278809	5/30 (17%)
		WW	417..443	CDD:197736	8/42 (19%)
		PH_ARHGAP9-like	499..613	CDD:270053	17/129 (13%)
		PH	499..611	CDD:278594	16/126 (13%)
		RhoGAP_ARHGAP27_15_12_9	728..914	CDD:239868	61/170 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840