Protein Alignment RhoGAP1A and pac-1

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: NP_498877.4
• Gene: pac-1 / 176201
• WormBaseID: WBGene00015418
• Length: 1605
• Species: Caenorhabditis elegans
• Alignment Length: 1469
• Identity: 292/1469 - (19%)
• Similarity: 504/1469 - (34%)
• Gaps: 465/1469 - (31%)

  Fly    54 EYLERLLSDVERYRVSGGDPKALFEAASGSCASSNNSNCSSTTNGATQEESNTNLDKDFKSSLNL 118
            |:..||....||..|.|||   :.:.|.||.|..     ::.:....:::||.:|.::.:.|..|
 Worm     3 EHHRRLHVKAERASVIGGD---IVDGAFGSWALR-----AARSEHQLKQQSNEDLAQNARISALL 59

  Fly   119 RESPSSTGAKDKDRLSLNPDNKY-------------TTH-----------TNAVIGG-------- 151
            .|.        :.|:|..|.|.:             ||:           .||:.|.
 Worm    60 GEM--------RPRMSAMPPNGHQQQYQPQLRRKANTTNIVDVSSQVPSARNAIYGSWQDRHRPT 116

  Fly   152 --IGSEKVSG----PLH-------STQITADGK-----RTGELYLKREEDKCKDSNSEDTDGALQ 198
              .||:.||.    |.:       ::.:|.:|.     .||   ::||..:.  .|...:....|
 Worm   117 RLYGSQLVSSSSTLPKYDQLYCNTASPLTGNGSTNTIATTG---IRREPPEY--GNVGRSVSTWQ 176

  Fly   199 QCITELAASLKAQPDNVAGGRLENDVDIDKPLRK---STSQYVTVIQVKEAKDKESADGTTSSSG 260
            ...:|...||:|       |.|::    .:||.:   |.:.|.        :|.|:..|:.:||.
 Worm   177 VTNSEHRPSLQA-------GWLKS----SRPLARGALSPAAYF--------RDLENRHGSGASSP 222

  Fly   261 IGEPQQQPTPPSTFSRYSEATAPPLSPSLTSYAAHVEAKKKMPPRPPPKNIRRVEPPTIPSQQLS 325
            |.........|.|......|...|:|..:::....::.:.        :.:...:...|....||
 Worm   223 IVGGLSVVAVPITQRHAPTAGLAPISDDISTSKVSLDTEN--------QQLNNEDSDKISGSALS 279

  Fly   326 -SSPKRETYM--INTMPSSSSGSLCIDSLGNSLERNIKPSDILRQKSSDNLDSKYSAKRKTTPEL 387
             ::|::.::|  :...|...| |..|:|.|..              ::...|...||..|..|
 Worm   280 RNTPRQASFMAAMQRHPLKES-STSIESNGGG--------------TNTEEDQTVSATSKEDP-- 327

  Fly   388 SKFVNVNNPELMEELGRKMVSKADSLEQTRRNDSSPSGCGSLGRTSSTPGRSLTPGRTGVGASPT 452
            |:....::||..:|:....:.::.:...:.||..|....|.|      ....|..|...||
 Worm   328 SEDTGHDDPEETQEISETPIRRSRNRNASLRNRQSSRSLGGL------DFEKLRMGTARVG---- 382

  Fly   453 GSLSKTGKLAMADSSSTSSLERRSCLQAVDADIGTESRESGANQRSVGSKESLTSQGISEVQIKS 517
                        ||:..:            |:.||.|..|..|.|..|...|.|:.........|
 Worm   383 ------------DSNEAT------------AENGTSSSSSRKNSRDDGLTSSPTTVAGPVFTTSS 423

  Fly   518 YESVSSLSSESAKAVASQQSAAAGGALAECEPYYDSVPLDNGDGEYVFIKPGRTGSSSSRDD--- 579
            ..|:|:....|:.|||    |||.|::|.                   ....:|.|:||.|.
 Worm   424 TSSISTSGEASSTAVA----AAAAGSVAA-------------------TTSRQTSSNSSVDSNHN 465

  Fly   580 -------LSTPGSSILPLPNVADPESPGRTSNYVNIDFFLQQGIETRSSSLDSDGEYEGPPILRT 637
                   .:.|.|.:|            .||..:|.|......|....||              :
 Worm   466 EAMKMIRRARPKSYVL------------ATSASMNEDVLSSSIIANEQSS--------------S 504

  Fly   638 ISHDDQTTTQTTPGAIRKNLVSAILVCGNARGAKIRSILSSIIQSETI--------------YVE 688
            ||||..|:.:..|.::..:.:|..:..|.|..|...:..:|..|:...              ::.
 Worm   505 ISHDTTTSGRELPSSLMGSTISMEMRSGGASSATTTTTSNSGQQTSRSLNAPHPPATHRLQRFIA 569

  Fly   689 CLNKMM------QYKKAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLSDLKTIVSHEGGD 747
            ..|...      ::||:......||.|..|.....||..:        .|...  :|.|.|:  :
 Worm   570 LFNSSKTSDGSGEHKKSRMKRSRTSLPASRFALPGTILQR--------DGVAR--QTWVKHQ--E 622

  Fly   748 VLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCS----ANNPQFKKIVSTIVLNLQTEQSLTLE 808
            :.:|:..:|            :|:::....:.:.|    ..:|.:           .||:::.|.
 Worm   623 IALGKSGKR------------NNWEDRWAVLCRRSLYLCVESPAY-----------TTEKTIELG 664

  Fly   809 DLLHKPVARVQI-NALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLR 872
            .  |   .||.: ||:|  |:..:.               :...|..|.:||  |: :..||:
 Worm   665 S--H---TRVDVCNAIV--DIAYDW---------------LSSSFSKQRHVV--RI-VTQNRS-- 702

  Fly   873 RMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYE-LKWFIPLKDVSIYEEADPAV 936
                              .||...|               .:.| |.|...|:..|
 Worm   703 ------------------EHLIELN---------------TESEMLSWISVLQSSS--------- 725

  Fly   937 ELKESSPANISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLG 1001
               |...|..|.|..|          |::.:|        ::........|.|:..:.::.....
 Worm   726 ---EDGIATGSSVDEN----------ELSTTG--------RHNNNAVSNSSALLHNSQSIASLAS 769

  Fly  1002 NKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQK------GMKTE 1060
            :..:..|.:.||:|.....|      ..:|:.|.....|:|  |::|.||:...      |:.|.
 Worm   770 SSCSTATTSEFLNSQHTLQQ------QQQQQTNQKHQQTVN--ELSAGIVSHLPTSKSFGGLSTT 826

  Fly  1061 MGSYLMRNTNDESLLVGDLYMGVHGLEGLEQANDLYICVEVD----------------SYGHYFR 1109
            ..|   ...|.::.|:...|:..:.......||..   :|.|                |:.|:..
 Worm   827 ASS---TTENAKNRLIMHRYIAKNSQLQSPTANKK---METDPSTVPSSSQTMATTSSSFHHHSS 885

  Fly  1110 KATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAKERPLLKAKHILKLSLSWLTETTQPKS-- 1172
            :|...:               ::|..           |.|...|              |.|||
 Worm   886 QAGPSR---------------DIENG-----------EAPTATA--------------TTPKSGR 910

  Fly  1173 ----IKLTETLELGCSFRFIPGELFRGST-KPGALFGAKMSQVLKREKRD-IPFIIGACIREVER 1231
                .|..:....|.|.....|...:|:. .|..:.|.:::........| :|.|:.||:..:|.
 Worm   911 KWKKSKAAKQGSGGGSSGSSSGSQQQGAAGAPQPVLGVRIADCPTGSCEDHVPMIVQACVCVIET 975

  Fly  1232 RGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLL-------REVDIHSVTGILKTFLRELPEA 1289
            .||..||.||:.|:.:.:..||::..:..:::..|.       |..|::.|:.:||.|||:|||.
 Worm   976 YGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNVVSSLLKMFLRKLPEP 1040

  Fly  1290 LFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHEKETDNKMSL 1354
            |.||:|||.|.|.....:::|   |:::|..:..:||:.:..::..::.||..:.:....|||..
 Worm  1041 LLTDKLYPFFIDANRISTHHN---RLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMEC 1102

  Fly  1355 HNLAMVFGPTLLRPGQTQVKQKDPLAASTVDVMAQAGIL 1393
            .|||::|||:::||..      |.:|.....:..|..|:
 Worm  1103 RNLALMFGPSIVRPSD------DNMATMVTHMSDQCKII 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	32/206 (16%)
		PH_BCR_arthropod	851..1037	CDD:270174	31/186 (17%)
		C2	1079..1187	CDD:301316	19/129 (15%)
		RhoGAP	1203..1398	CDD:295372	58/199 (29%)
pac-1	NP_498877.4	PH_ARHGAP21-like	613..728	CDD:269955	34/213 (16%)
		PH	617..726	CDD:278594	32/205 (16%)
		RhoGAP_ARHGAP21	945..1146	CDD:239860	58/200 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940