DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and T04C9.1

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_741163.2	Gene:	T04C9.1 / 175849	WormBaseID:	WBGene00020209	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	660	Identity:	143/660 - (21%)
Similarity:	243/660 - (36%)	Gaps:	183/660 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   820 INALVFNDLLRETP----NAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLRRMVRNSFI 880
            :.||.|:|.:.::|    |.|.....|..|.|.|::..||..
Worm     3 LRALEFSDSISDSPWFRQNLHDHEVALDDAFKNIKLIENQCK----------------------- 44

  Fly   881 VELVDGHRKLRHL-FLFNDVIACAKYKALGRDRIDYE------LKWFIPLKDVSIYEEADPAVEL 938
             ||:...:||... ..|...::..|::.:|.::.|.|      ||.|..|    |.:..|..::|
Worm    45 -ELIACTKKLSTAQRAFAKTLSEFKFETVGTNQTDDERFIATCLKEFGSL----INQVEDERMKL 104

  Fly   939 -KESSPANISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGN 1002
             .::..:.:..:|:.......:...|..|          ||     |.||.....|....|.|..
Worm   105 VGQAEESYLEPIKKFRTEAIGRTLKEEKN----------KY-----DKESSKFYQTLEKHLHLST 154

  Fly  1003 KANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTE----MGS 1063
            ..||         ||...   |:.|..:|| |...|    ||:..|.:.::|:.|:.|    :||
Worm   155 VRNN---------DFRAA---DAQLETQQK-NFFQA----SLQYVAEVQSVQERMRFEFVETLGS 202

  Fly  1064 YL---MRNTNDESLLVGDLYMGVHGLE-GLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLW 1124
            |:   :...:..|::..|....:..:: .:::..:.|.....::      :...||:..|.|.
Worm   203 YVYSWLSFFHVGSVIHQDFKPFLDNVQTKVQKTKENYNATNAEA------EELKKKLLASHTK-- 259

  Fly  1125 NESFMLELEGSQNVR---------ILLYEAKERPLLKAKHIL-------------------KLSL 1161
                    .||::.|         :.:.|..:.|....:.:|                   .:|.
Worm   260 --------PGSEDRRPTPSIKQGYVYMQEKSKIPKTIGRDVLLGRWTKYYCVYSRETRIFTMVSA 316

  Fly  1162 SWLTETTQPKSIKLTETLEL-GCSFRFIPG------------------ELFRGSTKP-----GAL 1202
            :..|:|....::..|.|.:. .||.|.:..                  .:...|.|.     .|:
Worm   317 NSATKTDMKSAVAQTATFKFKSCSRRPMDSIDKRFCFDVCVEEKNDVMTMQALSEKDLCEWIDAM 381

  Fly  1203 FGAKMSQVLKREK-----------RDIPF-IIGACIREVERRGMLEVGCYRVSGSASDLAKL--- 1252
            .|||.:.....|.           .||.| .:..||..:|..|:.|.|.||..|..|.:.|:
Worm   382 DGAKQNSYTAGENPSCSTYKQTQLDDIGFEFVQQCIDILEESGIHEQGVYRNCGVTSKVQKMMML 446

  Fly  1253 ----KKAFESDAYEAEQLLR--EVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNE 1311
                :||.|.....    ||  |.:..:::..:|||||.|||.|.|.:|:..|   .:|....:.
Worm   447 GLDRRKASEKGGLN----LRDDEWETKTISSAVKTFLRNLPEPLMTFELHNVF---INAAKMGDA 504

  Fly  1312 STRINELLKVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVKQK 1376
            :.||:.:.....:||..:...:..::.||.||.:...:|.|::.||.:.||||||||       |
Worm   505 TMRIDHIHFYVHQLPAQHLRMLEIVVRHLKRVADLSNENLMTVSNLGVCFGPTLLRP-------K 562

  Fly  1377 DPLAASTVDV 1386
            :...|:.:|:
Worm   563 EETVAAIMDI 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	13/40 (33%)
		PH_BCR_arthropod	851..1037	CDD:270174	38/193 (20%)
		C2	1079..1187	CDD:301316	18/137 (13%)
		RhoGAP	1203..1398	CDD:295372	60/205 (29%)
T04C9.1	NP_741163.2	BAR_RhoGAP_OPHN1-like	19..225	CDD:153286	56/265 (21%)
		BAR-PH_GRAF_family	271..388	CDD:269953	17/116 (15%)
		RhoGAP	381..585	CDD:295372	60/206 (29%)
		SH3_GRAF-like	826..879	CDD:212815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.030