Protein Alignment RhoGAP1A and tag-325

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: NP_001309440.1
• Gene: tag-325 / 175636
• WormBaseID: WBGene00008006
• Length: 840
• Species: Caenorhabditis elegans
• Alignment Length: 1163
• Identity: 222/1163 - (19%)
• Similarity: 372/1163 - (31%)
• Gaps: 448/1163 - (38%)

  Fly   321 SQQLSSSPKRETYMINTMPSSSSGSLCIDSLG------------NSLERNIKPS---------DI 364
            ::..|||.:......||:|..|:|....|...            ||..|.:.|:         |:
 Worm    37 AESSSSSSQTNVSAANTLPRESNGQNYADDPSHVYTNIREIEELNSFSRPVPPTPRADAQPRRDL 101

  Fly   365 LRQKSSDNLD-------SKYSAKRKTTPELSKFVNVNNPELMEELGRKMVSKADSLEQTRRNDSS 422
            |........|       :|.:.|.:..|  .:|  :..|..::|.          |..||.|
 Worm   102 LNGWFEYETDVGRTFFFNKETGKSQWIP--PRF--IRTPAQVQEF----------LRATRTN--- 149

  Fly   423 PSGCGSLGRTSSTPGRSLTPGRTGVGASPTGSLSKTGKLAMADSSSTSSLERRSCLQAVDADIGT 487
                  |..|.|..|                             |||||.|.:.         ..
 Worm   150 ------LDTTCSFQG-----------------------------SSTSSSEEQK---------EN 170

  Fly   488 ESRESGANQRSVGSKESLTSQGISEVQIKSYESVSSLSSESAKAVASQQSAAAGGALAECEPYYD 552
            :.|||.|:       :...||.|.:.::  ::.|.....|.:..|...||....      .|:.|
 Worm   171 KMRESLAD-------DDRKSQLIEDEEV--FDEVCDDVDEQSSPVIDLQSRPLP------IPFSD 220

  Fly   553 SVPLDNGDGEYVFIKP--GRTGSSSSRDDLSTPGSS---------ILPLPNVADPESPGRTSNYV 606
            |...|..:.:   :||  |...|.|..|:...|.||         ::|.|             |.
 Worm   221 SFTDDEDEDD---VKPIEGSIASDSDFDEEPVPTSSRKASTASGVMMPHP-------------YA 269

  Fly   607 NIDFFLQQGIETRSSSLDSD--GEYEGPPILRTISHDDQTTTQTTPGAIRKNLVSAILVCGNARG 669
            ::..|  |....|:.:.|:|  ..|..||        |...|..||.|||....|..    |.|.
 Worm   270 HVSSF--QSTFPRAKNEDTDKLASYVIPP--------DANETSKTPTAIRVRRPSPT----NLRS 320

  Fly   670 AKIR---SILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDELYDLHT 731
            ...:   ::|.::...:.:  ...:....:....|:. |..:|::.|:..:
 Worm   321 VSFQNKCTVLKNVPMPQVL--PTTSSSFDHHPQYHSN-TPDRPILMEDSAD-------------- 368

  Fly   732 GFLSDLKTIVSHEGGDVLIG-EPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTI 795
             |....:.......||   | ||.|.:                      :|
 Worm   369 -FTPSSRCEERRGSGD---GREPVRTI----------------------RC-------------- 393

  Fly   796 VLNLQTEQSLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVN 860
                                          .||.| :.|..|       |:|:::
 Worm   394 ------------------------------GDLER-SENDEP-------AEKVVK---------- 410

  Fly   861 QRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKD 925
                    ...|..:.|...:...       ||.|:.|..:..|:   |:.....:..|.:....
 Worm   411 --------PKKREWITNYMYLTTA-------HLILYKDQKSAEKH---GKHYDAPQGVWDLRGAS 457

  Fly   926 VSIYEEADPAVELKESSPANISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLV 990
            |:.|::.....:.|:                |..:.:|:.|:        .||           :
 Worm   458 VTWYQDNRDVQKKKQ----------------RKYIQLELCNT--------KKY-----------L 487

  Fly   991 LATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQK 1055
            |..||                    |.|..:|..|:..:..|...||::....::||
 Worm   488 LRGPN--------------------DTEAVEWYKSLEEVVAKLPSPGSSNQPMIDVT-------- 524

  Fly  1056 GMKTEMGSYLMRNTNDESLLVGDLYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQ 1120
                   :.:.||.:         |:|                             :|:.:..:.
 Worm   525 -------NGVARNPS---------YIG-----------------------------STRPLSHAL 544

  Fly  1121 TPLWNESFMLELEGSQNVRILLYEAKERPLLKAKHILKLSLSWLTETTQPKSIKLTETLELGCSF 1185
            .|:           |:::|     .::.|:.::. |..:|.|..|:..:|....:.|.|.
 Worm   545 IPI-----------SRSMR-----RRDDPMSQSA-IETVSTSVSTDEPRPSKETIIEKLR----- 587

  Fly  1186 RFIPGELFR-----------GSTKPGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGC 1239
            ||     ||           |..||..:||:.:|.:.:.|...:|..|......:|.:|:...|.
 Worm   588 RF-----FRTRPTVESLKEKGIYKPEPVFGSTLSAICQHENSLVPKFIRVITEVIESKGLETDGI 647

  Fly  1240 YRVSGSASDLAKLKKAFESDAYEAEQLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFS 1304
            |||||:.|.:.|::...:.|.|:|  |:.|.|||.:||.||.|.|||.:.||...|:..:   .|
 Worm   648 YRVSGNLSAVQKIRCQADQDNYKA--LVSEEDIHVLTGALKLFFRELTDPLFPISLHKEY---TS 707

  Fly  1305 AFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLL--- 1366
            |....|.:||..:..::...||..|:.::..:|.||.||....:.|:|..||||:||||||.
 Worm   708 AMQMPNATTRFKKFEELLSRLPNENRETLKMLLRHLNRVASHSSQNRMQQHNLAIVFGPTLFHNG 772

  Fly  1367 -----------------RPGQTQVKQKDPLAAST---VDVMAQAGILYCFLQARIKKD 1404
                             :|.:.:..|..|:.:::   ..::.|:.|:...|::..|.|
 Worm   773 DGAVNLATKNKKAGKKAKPSKKEETQATPVQSNSHLAFSMIMQSQIVQYLLESANKFD 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	20/182 (11%)
		PH_BCR_arthropod	851..1037	CDD:270174	25/185 (14%)
		C2	1079..1187	CDD:301316	14/107 (13%)
		RhoGAP	1203..1398	CDD:295372	65/217 (30%)
tag-325	NP_001309440.1	WW	101..130	CDD:278809	5/30 (17%)
		PH_ARHGAP9-like	391..509	CDD:270053	32/274 (12%)
		PH	407..508	CDD:278594	25/183 (14%)
		RhoGAP_ARHGAP27_15_12_9	611..825	CDD:239868	66/218 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I4545
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto20506
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.940