DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP1A and rga-1

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_001022390.1	Gene:	rga-1 / 174751	WormBaseID:	WBGene00012203	Length:	444	Species:	Caenorhabditis elegans

Alignment Length:	184	Identity:	54/184 - (29%)
Similarity:	89/184 - (48%)	Gaps:	16/184 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly  1199 PGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKL--------KKA 1255
            |...||..:..:|.....:||.|:...|..:|...:...|.:|.|.:...:.:|        |..
Worm   243 PTQQFGVPLEFILSHCGGNIPPIVDQLIEYLEAHALTMEGVFRKSANIGSIKRLQDRINKGEKID 307

  Fly  1256 FESD-AYEAEQLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELL 1319
            ||:| .|:..:.:  ..:|: :.:||||.|.|.|.|.|::|||: ....|..|...:|..:.|.:
Worm   308 FENDPEYKDNEYV--ASLHA-SVLLKTFFRSLGEPLTTNRLYPK-LAALSEVSKTEKSAAVKEFV 368

  Fly  1320 KVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQV 1373
            |:   ||:.|...:.:::..|.||.|....|.|:.:||::||||.|..|...:|
Worm   369 KL---LPRENYILLKTVIKFLTRVAENSKVNLMTANNLSVVFGPNLTWPTDQEV 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619
		PH_BCR_arthropod	851..1037	CDD:270174
		C2	1079..1187	CDD:301316
		RhoGAP	1203..1398	CDD:295372	53/180 (29%)
rga-1	NP_001022390.1	SEC14	74..225	CDD:214706
rga-1	NP_001022390.1	RhoGAP	242..442	CDD:383032	54/184 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940