DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and CHN1

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_001358443.1	Gene:	CHN1 / 1123	HGNCID:	1943	Length:	476	Species:	Homo sapiens

Alignment Length:	462	Identity:	111/462 - (24%)
Similarity:	190/462 - (41%)	Gaps:	114/462 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   954 RSVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFE 1018
            |...|||.  :...||...|            |||....|..|.||.|::..|..: ::....|.
Human    73 REAADQLL--IVAEGSYLIR------------ESQRQPGTYTLALRFGSQTRNFRL-YYDGKHFV 122

  Fly  1019 RTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDLYMGV 1083
            ..:..:||..|                ||..::.:.  ::|:...|:.:.|      :..:|..|
Human   123 GEKRFESIHDL----------------VTDGLITLY--IETKAAEYIAKMT------INPIYEHV 163

  Fly  1084 -------------HGLEGLEQANDLYICVEVDSYGH----------YFRKATTKKICRSQTPLWN 1125
                         | :..|::.:|     |.||.|.          ..|:||.|:  ..|.|
Human   164 GYTTLNREPAYKKH-MPVLKETHD-----ERDSTGQDGVSEKRLTSLVRRATLKE--NEQIP--- 217

  Fly  1126 ESFMLELEGSQNVRILLYEAKERPLLKAKHILKLSLSWLTETTQPKSIKLTE---TLELGCSFRF 1187
                 :.|...|.::..:        :..|..:...:::.... .:.:|..:   .:...|| :.
Human   218 -----KYEKIHNFKVHTF--------RGPHWCEYCANFMWGLI-AQGVKCADCGLNVHKQCS-KM 267

  Fly  1188 IPGELFRGSTKPG-----ALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSAS 1247
            :|.:     .||.     .::...::.::|......|.::..||||:|.||:...|.|||||.:.
Human   268 VPND-----CKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSD 327

  Fly  1248 DLAKLKKAFESDAYEAE-QLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNE 1311
            .:..:|.||:.|..:|: .:....||:.:||.||.:.|:||..|.|...||:|.::......:.:
Human   328 LIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQ 392

  Fly  1312 STRINELLKVFEELPQANKASITSILDHLIRV--HEKETDNKMSLHNLAMVFGPTLLRPGQTQVK 1374
            ...::|.||:   ||.|:..::..::.||.||  ||||  |.|:..||.:||||||:|.     .
Human   393 LETLHEALKL---LPPAHCETLRYLMAHLKRVTLHEKE--NLMNAENLGIVFGPTLMRS-----P 447

  Fly  1375 QKDPLAA 1381
            :.|.:||
Human   448 ELDAMAA 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619
		PH_BCR_arthropod	851..1037	CDD:270174	20/82 (24%)
		C2	1079..1187	CDD:301316	21/133 (16%)
		RhoGAP	1203..1398	CDD:295372	62/182 (34%)
CHN1	NP_001358443.1	SH2	67..145	CDD:387587	22/104 (21%)
		C1_1	223..272	CDD:365894	6/63 (10%)
		RhoGAP_chimaerin	283..476	CDD:239837	62/182 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940