DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and Abr

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_932135.1	Gene:	Abr / 109934	MGIID:	107771	Length:	871	Species:	Mus musculus

Alignment Length:	866	Identity:	293/866 - (33%)
Similarity:	476/866 - (54%)	Gaps:	103/866 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 FLQQGIETRSSSLDSDG--EYEGPPI-LRTISHDDQTTTQTTPGAIRK----NLVSAILVCGNA- 667
            ||.......:...|::|  |.:|||. ..|:.:.|::.|.:...:.|.    :.||.....|.|
Mouse    29 FLVSDFSYGAEDYDAEGHEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDSVSPTPPEGLAP 93

  Fly   668 -----RGAKIRS-ILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDEL 726
                 :|.::|. :||..:.||.||:..|..::...|.:.||.||||||:..::..|||:||.::
Mouse    94 GVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDI 158

  Fly   727 YDLHTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKI 791
            |::|..|..:|...|......|.:|..|::||....:|.||:.|||.|:||.:|||.:|.||:||
Mouse   159 YEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKI 223

  Fly   792 VSTIVL-----NLQTEQSLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQM 851
            ...:.:     :..:..|:|:|.||:||:.||..:.||.:|||:.||..|||:..|:.|.:|.|.
Mouse   224 SEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQN 288

  Fly   852 FLNQFN--VVNQRLPIESNR-NLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYK--ALGRD 911
            ||:..|  :..:|..:.:.: ..|::|::.|:||:.:..|||||:|||.||:.|||.|  :.|:.
Mouse   289 FLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEMSESSRKLRHVFLFTDVLLCAKLKKTSAGKH 353

  Fly   912 RIDYELKWFIPLKDVSIYEEADPAVELKESSPA-------NISQVKRNLRSVRDQLAMEVANSGS 969
            : .|:.||:|||.|:..     |:.|..|:||.       .:..:|..:.:::.::..|.||.|.
Mouse   354 Q-QYDCKWYIPLADLVF-----PSPEESEASPQVHPFPDHELEDMKTKISALKSEIQKEKANKGQ 412

  Fly   970 GAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKCN 1034
            .  |:.::.::|:.:.|..|:|.:|.:..|:.|: |.|:..|.||||:||::|.::|..|::|
Mouse   413 S--RAIERLKKKMFENEFLLLLNSPTIPFRIHNR-NGKSYLFLLSSDYERSEWREAIQKLQKK-- 472

  Fly  1035 LPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNT-----------NDESL-LVGDLYMGVHGLE 1087
                      ::.||:::..: ::...||.....|           :|||. |.|.|::.||..:
Mouse   473 ----------DLQAFVLSSVE-LQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAK 526

  Fly  1088 GLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEA------- 1145
            |.:|:.:||..:||||:|::..||.|:....:..|.|:|.|.:||||||::|||.||.
Mouse   527 GFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTTEPKWDEEFEIELEGSQSLRILCYEKCYDKTKV 591

  Fly  1146 -KER----PLLKAKHILKL------SLSWLTETTQPKSIKLTETLEL---GCSFRFIPGELFRGS 1196
             |:.    ..:..|..::|      |.:|.|:..:...||:..:::.   ..|.:..|      |
Mouse   592 NKDNNEIVDKIMGKGQIQLDPQTVESKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTP------S 650

  Fly  1197 TKPGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAY 1261
            .|...:||.|:|.|.|||:..:|:|:..||.|||:||:.|||.||:||.|:|:..||..|:::..
Mouse   651 KKQTGVFGVKISVVTKRERSKVPYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 715

  Fly  1262 EAEQLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELP 1326
            :...:|.::||:::.|.||.:.|||||.|.||:|||.|.:   ..:.::.:.:.|.::.:...||
Mouse   716 DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFME---GIALSDPAAKENCMMHLLRSLP 777

  Fly  1327 QANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVKQKDPLAAS--TVDVMAQ 1389
            ..|..:...:|:||.||.|||..|||||||||.|||||||||.:.:.|.....||.  :.|||||
Mouse   778 DPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQ 842

  Fly  1390 AGILYCFLQ------ARIKKD 1404
            ..:|..:||      |.:|::
Mouse   843 VQVLLYYLQHPPISFAELKRN 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	73/186 (39%)
		PH_BCR_arthropod	851..1037	CDD:270174	62/197 (31%)
		C2	1079..1187	CDD:301316	39/128 (30%)
		RhoGAP	1203..1398	CDD:295372	86/196 (44%)
Abr	NP_932135.1	RhoGEF	104..294	CDD:238091	74/189 (39%)
		PH_ABR	289..472	CDD:270172	61/191 (32%)
		C2_ABR	518..638	CDD:176068	38/119 (32%)
		RhoGAP_Bcr	657..852	CDD:239852	87/197 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849786
Domainoid	1	1.000	148	1.000	Domainoid score	I4448
eggNOG	1	0.900	-	-		E1_KOG4269
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11081
Inparanoid	1	1.050	471	1.000	Inparanoid score	I1497
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	1	1.000	-	-		FOG0002220
OrthoInspector	1	1.000	-	-		otm43093
orthoMCL	1	0.900	-	-		OOG6_104879
Panther	1	1.100	-	-	LDO	PTHR23182
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	1	1.000	-	-		X2211
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790