DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP1A and Chn1

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	XP_006498620.2	Gene:	Chn1 / 108699	MGIID:	1915674	Length:	541	Species:	Mus musculus

Alignment Length:	446	Identity:	105/446 - (23%)
Similarity:	183/446 - (41%)	Gaps:	94/446 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1001 GNKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANTIN------------------SLEVT 1047
            |.:.:...:|.|.:.::....|...:..|:|:...|...|..                  |.|.|
Mouse   103 GRRGSTMALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRVTCTCEVENRPKYYGREYHGMISREET 167

  Fly  1048 AFIVAMQKGMKTEMGSYLMRNTNDE------SLLVGD-------LYMGVH--GLEGLEQANDLY- 1096
            ..::::.:      ||||:|.:..:      :|..|.       .|.|.|  |.:..|..:||.
Mouse   168 DQLLSVAE------GSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVT 226

  Fly  1097 -----ICVEVDSYGHYFRKATTKKICR-------SQTPLWNESFML--------ELEGSQNVRIL 1141
                 :.:|..: ..|..|.|...|..       ::.|.:.:...:        |..|...|
Mouse   227 DGLITLYIETKA-AEYIAKMTINPIYEHIGYTTLNREPAYKQHMAVLKETHDEKEATGQDGV--- 287

  Fly  1142 LYEAKERPLLKAKHILKLSLSWLTETTQPKSIKLTE---TLELGCSFRFIPGELFRGSTKPG--- 1200
              ..|.....:..|..:...:::.... .:.:|..:   .:...|| :.:|.:     .||.
Mouse   288 --SEKRVHTFRGPHWCEYCANFMWGLI-AQGVKCADCGLNVHKQCS-KMVPND-----CKPDLKH 343

  Fly  1201 --ALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEA 1263
              .::...::.::|......|.::..||||:|.||:...|.|||||.:..:..:|.||:.|..:|
Mouse   344 VKKVYSCDLTTLVKAHITKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKA 408

  Fly  1264 E-QLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQ 1327
            : .:....||:.:||.||.:.|:||..|.|...||:|.::......:.:...::|.|:   .||.
Mouse   409 DISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALR---SLPP 470

  Fly  1328 ANKASITSILDHLIRV--HEKETDNKMSLHNLAMVFGPTLLRPGQTQVKQKDPLAA 1381
            |:..::..::.||.||  ||||  |.||..||.:||||||:|.     .:.||:||
Mouse   471 AHCETLRYLMAHLKRVTLHEKE--NLMSAENLGIVFGPTLMRS-----PELDPMAA 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619
		PH_BCR_arthropod	851..1037	CDD:270174	6/35 (17%)
		C2	1079..1187	CDD:301316	21/133 (16%)
		RhoGAP	1203..1398	CDD:295372	63/182 (35%)
Chn1	XP_006498620.2	SH2_a2chimerin_b2chimerin	150..236	CDD:198215	17/91 (19%)
		C1_1	291..337	CDD:365894	5/52 (10%)
		RhoGAP_chimaerin	348..541	CDD:239837	63/182 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940