DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP1A and arhgap31

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	XP_005165688.1	Gene:	arhgap31 / 101885883	ZFINID:	ZDB-GENE-100922-256	Length:	1391	Species:	Danio rerio

Alignment Length:	204	Identity:	58/204 - (28%)
Similarity:	102/204 - (50%)	Gaps:	23/204 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1203 FGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLL 1267
            ||..:|:.|:...:|:|.::..|...:|:.|::: |.||:||..|::.||::.|.|:.  ...|.
Zfish    19 FGCDLSEHLQSSGQDVPHVLKTCAEFIEKHGIVD-GIYRLSGITSNIQKLRQEFSSEL--CPDLT 80

  Fly  1268 REV---DIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQAN 1329
            :||   |||.|..:.|.:.||||..|.|.:||.:|   ..|.|...|..::..:....:|||:::
Zfish    81 KEVYLQDIHCVGSLCKLYFRELPNPLLTYELYSKF---THAVSVKEEQEQLRNIRSAIKELPESH 142

  Fly  1330 KASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVKQKDPLAASTVDVMAQAGILY 1394
            ..::..:..||..:........|...|||:|:.|.|||..:.:|      .:...|:
Zfish   143 FRTLEYLTKHLAYLATLSHQTNMHARNLALVWAPNLLRSKEVEV------PSCNGDI-------- 193

  Fly  1395 CFLQARIKK 1403
            .||:.|:::
Zfish   194 AFLEVRVQQ 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619
		PH_BCR_arthropod	851..1037	CDD:270174
		C2	1079..1187	CDD:301316
		RhoGAP	1203..1398	CDD:295372	56/197 (28%)
arhgap31	XP_005165688.1	RhoGAP_CdGAP	18..211	CDD:239849	58/204 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030