Protein Alignment RhoGAP1A and arhgap9

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: XP_005172184.2
• Gene: arhgap9 / 100334461
• ZFINID: ZDB-GENE-110510-2
• Length: 855
• Species: Danio rerio
• Alignment Length: 961
• Identity: 193/961 - (20%)
• Similarity: 326/961 - (33%)
• Gaps: 327/961 - (34%)

  Fly   490 RESGANQRSVGSKESLTSQGI--------SEVQIKSY-ESVSSLSSESAKAVASQQSAAAGGALA 545
            |.|..|.:|...:..:.|:|.        ..|..|.: .|:.:|:..|| .:..|.|.||..|..
Zfish   106 RTSLPNSQSASERFQMISRGSLMPCMHTHGSVPDKQFCRSMENLNCSSA-LMEKQASGAAARAHF 169

  Fly   546 ECEPYYDS----VPLDNGDGEYVFIKPG----RTGSS----------SSRDDLSTPGSSILPLP- 591
            ...|:..|    :.|..|     .:.||    |:.||          |||....:|..|.....
Zfish   170 PMLPFSGSASAQLTLPGG-----LLSPGAPIARSQSSSNLPQNPYQESSRSTACSPSRSYSQWDM 229

  Fly   592 NVADPESPGRTSNYVNIDFFLQQGIETRSSSLDSDG--EYEGPPI-------LRTISHDDQTTTQ 647
            |.|.|.........::...::.|      |||...|  ::..||.       |:|:...:|
Zfish   230 NTAAPRRHTHGHMQLSSSAYISQ------SSLSEAGRRQWSEPPSPLPGQKPLQTLQQWEQ---- 284

  Fly   648 TTPGAIRKNLVSAILVCGNARGAKIRSILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQPVIR 712
                           .|..|.|             ...|:....|...:|....|..|.....:.
Zfish   285 ---------------YCDPATG-------------RCYYINTDTKERSWKPPRRARQTNHSQQVN 321

  Fly   713 EEEENTIFFKIDELYDL---HTGFLS------DLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFL 768
            .....|:...| .|..|   .||..|      || :.:||:.....:.:..:|.|.
Zfish   322 AVHAGTVQRDI-RLLSLPLQSTGSSSMHRLSPDL-SYISHDANGWQLSQSMQRAAS--------- 375

  Fly   769 HNYKNAIETVKKCSANNPQFKKIVSTIVLNLQTEQSLTLEDLLHKPVARVQINALVFNDLLRETP 833
               .:|:.:......:.|:....:|..:.::....|:.|      |..|...|......::.|.|
Zfish   376 ---SDALSSASSMFDDTPRRNSALSGGMAHISHSYSMIL------PSQRTATNGQSDYRVVVEPP 431

  Fly   834 --NAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLF 896
              ::.||.:.:...       |.:..::|:                   .::.:|.||||.
Zfish   432 SSDSSPDSEGVTPE-------LEKAGLLNK-------------------TKIAEGGRKLRK---- 466

  Fly   897 NDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEADPAVELKES-SPANI---SQVKRNLRSVR 957
                             ::...|.:.:.:..::.: ||..:..|| .|.|.   |.|  :||..:
Zfish   467 -----------------NWNPSWVVLVGNSLVFFK-DPKSQNPESWKPGNSRPESSV--DLRGAQ 511

  Fly   958 DQLAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTIT---FFLSSDFER 1019
            .|.|.:                           |::...|.:|      :|||   |.|.|:.:.
Zfish   512 LQWAND---------------------------LSSKKNVFKL------RTITGNEFLLQSETDS 543

  Fly  1020 --TQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDLYMG 1082
              .:|..:|.::..:  |...|.::::    .:.::::....|    |:.::.||..:.|.:...
Zfish   544 LIREWYRTIQNVIDR--LDKENPLDNV----LLYSLRRAGSVE----LLDHSGDEDEVRGGIKAS 598

  Fly  1083 V-HGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAK 1146
            : .....||.:.            |...|:..||:...:.||
Zfish   599 LPRSTSNLENSE------------HKRVKSRLKKLILRRPPL----------------------- 628

  Fly  1147 ERPLLKAKHILKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGELFRGSTKPGALFGAKMSQVL 1211
                               :|.|.|.:...:                        :||..:..:.
Zfish   629 -------------------QTLQEKGLIKDQ------------------------VFGCSLELLC 650

  Fly  1212 KREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLK------KAFESDA--YEAEQLLR 1268
            :|||..:|..:..|...|||:|:...|.|||||:.:.:.||:      :|..:|.  ...|.|::
Zfish   651 EREKCTVPQFVRKCTEAVERKGLETDGIYRVSGNLAVIQKLRFAVNHERAVTTDGRYLFPEALVQ 715

  Fly  1269 E---------VDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFE- 1323
            |         .|||.:||.||.|.|||||.|.          .||||.:..:|.:|.:.|:..|
Zfish   716 ERLDLDDPQWEDIHVITGALKLFFRELPEPLV----------PFSAFHDFVDSIKIADHLERVER 770

  Fly  1324 ------ELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRP 1368
                  .||.||:.::..::.||.||.|:...|:||..|:.:||||||:||
Zfish   771 LKMLVLSLPPANQHTLQHMIRHLRRVMERSDSNRMSTQNIGIVFGPTLMRP 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	31/192 (16%)
		PH_BCR_arthropod	851..1037	CDD:270174	32/194 (16%)
		C2	1079..1187	CDD:301316	11/108 (10%)
		RhoGAP	1203..1398	CDD:295372	67/190 (35%)
arhgap9	XP_005172184.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940