Protein Alignment RhoGAP1A and bcr

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: NP_001123792.1
• Gene: bcr / 100170543
• XenbaseID: XB-GENE-980812
• Length: 1162
• Species: Xenopus tropicalis
• Alignment Length: 1290
• Identity: 380/1290 - (29%)
• Similarity: 597/1290 - (46%)
• Gaps: 258/1290 - (20%)

  Fly   192 DTDGALQQCITELAASLKAQPDNVAGGRLENDVDIDKPLRKSTSQYVTVIQVKEAKDKESADGTT 256
            |.:..|::|    .||::         |||.:::.:: .|      :..:|...||::...|  .
 Frog    28 DMEQELERC----RASVR---------RLERELNRER-FR------MIYLQTLLAKERRGYD--R 70

  Fly   257 SSSGIGEPQQQPTPPSTF--SRYSEATAPPLSPSLTSYAAHVEAKKKMP-PRPPPKNIRRVEPPT 318
            ...|..:.|.|......|  .|.........||         |...|.| .|.||.....:.|..
 Frog    71 QRWGFEDRQHQAGERDPFGEERVKSTGREERSP---------ENSIKGPGRREPPVGAPDLSPGD 126

  Fly   319 I---PSQQLS----SSPKRETYMINTMPSSSSGSLCIDSLGNSLERNIKPSDILRQKSSDN---L 373
            :   |.:.||    ..|::.:..:....|...||..:.....:..|.|      |.:|||:   .
 Frog   127 VNRGPRRLLSLTEREDPEQRSDRLRRASSHPEGSPGLRGPQVAEHRGI------RGRSSDSSCGW 185

  Fly   374 DSKYSAKRKTTPELSKFVNVNNPELMEELGRKMVSKADSLEQTRRNDSSPSGCGSLGRTSSTPGR 438
            |.:|.     .|||       ||..:                  |:::.|...|:.|  .:.|.|
 Frog   186 DGEYE-----EPEL-------NPRFL------------------RDNALPGTGGNWG--EAWPRR 218

  Fly   439 SLTPGR---TGVGASPTGSLSKTGKLAMADSSSTSSLERRSCLQAVDADIGTESRESGANQRSVG 500
            |.:|..   .|.|.:|             |.||..:|              |.|.|    :.|.|
 Frog   219 SFSPRSFEDLGGGYTP-------------DCSSNENL--------------TSSEE----ELSSG 252

  Fly   501 SKESLTSQGISEVQIKSYESVSSLSSESAKAVASQ-QSAAAGGALA----------EC-EPY-YD 552
            ....::.:||..   :|..|..|.|..:.:|.|.| |...|..|:.          .| ||. .|
 Frog   253 PSGRVSPRGIWS---RSPPSPGSASPPTPQAPARQCQLRIAEAAIVGVRRSGQIWPSCAEPVGRD 314

  Fly   553 SVPLDNGDGEYVFIKPGRTGSSSSRDDLSTPGSSILPLPNVADPESPGRTSNYVNIDFFLQQGIE 617
            .....:||..:....||.|....|:.||       :|..:.:...||             |...:
 Frog   315 QGCHGDGDASHCRASPGGTEEQRSQHDL-------MPFIDESPSSSP-------------QLSAK 359

  Fly   618 TRSSSLDSDGEYEGPPILRTISHDDQTTTQTTPGAIRKNLVSAILVCGNARGAKIRS-ILSSIIQ 681
            :|.|.             .|:|.....::::|...:.|             |.::|. :||:|:.
 Frog   360 SRGSR-------------DTLSSGSLESSKSTELDLEK-------------GLEMRKWVLSAILA 398

  Fly   682 SETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLSDLKTIVSHEGG 746
            .|..|:..|..::...|.:.|..||||||:..::..|||||:.|||::|..|...|...|.....
 Frog   399 GEETYLSHLEALLLPMKPLKAAATTSQPVLTVQQIETIFFKVPELYEIHKEFYDSLFPRVQKWSH 463

  Fly   747 DVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNLQTE-----QSLT 806
            ...:|:.|::||....:|.||:.||:.|:||.:||...|.||.:|...:......|     ...|
 Frog   464 QQRVGDLFQKLASQLGVYRAFVDNYEVAMETAEKCCQANAQFAEISENLKARNTREPKDHSSKTT 528

  Fly   807 LEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVV----NQRLPIES 867
            ||.||:|||.||..:.||.:||::.||..|||:..|:.|.:|.|.||:..|..    .|.:.:..
 Frog   529 LEALLYKPVDRVTRSTLVLHDLIKHTPIGHPDYPLLQDALRISQNFLSSINEEITPRRQSMTVRK 593

  Fly   868 NRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKY-KALGRDRIDYELKWFIPLKDVSI--Y 929
            ..: |:::::||:||||:|.|||||:|||.|::.|||. |.:|.....|:.||:|||.|::.  .
 Frog   594 GEH-RQLLKDSFMVELVEGARKLRHVFLFTDLLLCAKLKKQIGGKSQQYDCKWYIPLADLNFQTV 657

  Fly   930 EEADPAVELK-------ESSPANISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADLES 987
            :|::.|..:.       |:....|||:|.:::  |::.|.:   .|.|.    ::.|:||::.||
 Frog   658 DESETASNIPMIPDDEIEAIKVKISQLKSDIQ--REKKAHK---GGKGL----ERLRKKLSEQES 713

  Fly   988 QLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANTINSLEV---TAF 1049
            .|:|.:|::..|:.|: |.|:.|....||:||.:|.:.|...::||.  .:.:::|||:   |..
 Frog   714 VLLLVSPSMAFRIQNR-NGKSYTLLTWSDYERAEWAEHIREQQKKCF--KSFSLSSLEIQMLTNS 775

  Fly  1050 IVAMQKGMKTEMGSYLMRNTNDESLLVGDLYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTK 1114
            .|.:|...:..:  .|.:..::.|.|.|.|.:.||...|.:|:::|:..:||||:|::..||.|:
 Frog   776 CVKLQTVHRVPL--TLSKEDDESSGLYGFLNVIVHSATGFQQSSNLFCTLEVDSFGYFVNKAKTR 838

  Fly  1115 KICRSQTPLWNESFMLELEGSQNVRILLYEA---KERPL----------------LKAKHILKLS 1160
            ....:..|.|||.|.:||||||.:|||.||.   :.||:                ::.:..|.|.
 Frog   839 VYRNTTEPNWNEEFEIELEGSQTLRILCYEKSCNRNRPMKEDGGDSSERMVAKGQVQLESQLALG 903

  Fly  1161 LSWLTETTQPKSIKLTETLELGCSFRFIPGE--LFR-GSTKPGALFGAKMSQVLKREKRDIPFII 1222
            ..|      .:|:.....:|:..|.:|...|  |.| .|.|...:||.|::.|.|||:..:|:|:
 Frog   904 KDW------HRSVVSMNGIEVKLSMKFTSREFSLKRLPSRKQTGVFGVKIAVVTKRERSKVPYIV 962

  Fly  1223 GACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLLREVDIHSVTGILKTFLRELP 1287
            ..|:.|:||||:.|||.|||||.|:|:..||.||:::..:...::.::|::::.|.||.:.||||
 Frog   963 RQCVEEIERRGLEEVGIYRVSGVATDIQALKNAFDANNKDVSVMMSDMDVNAIAGTLKLYFRELP 1027

  Fly  1288 EALFTDQLYPRFFDTFSAFSN--NNESTRINELLKVFEELPQANKASITSILDHLIRVHEKETDN 1350
            ..||||:|||.|.:.. |.|:  ..||..:|.||    .||:.|..:...:||||.||.|.|:.|
 Frog  1028 APLFTDELYPNFAEGI-ALSDPVAKESCMLNLLL----SLPEPNLLTFLFLLDHLKRVAENESQN 1087

  Fly  1351 KMSLHNLAMVFGPTLLRPGQTQ----VKQKDPLAAS---TVDVMAQAGILYCFLQ 1398
            ||||||||.|||||||||.:..    |....|::.:   :::||:|..:|..|||
 Frog  1088 KMSLHNLATVFGPTLLRPSEKDSKIPVNPTQPISMADSWSLEVMSQVQVLLYFLQ 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	70/186 (38%)
		PH_BCR_arthropod	851..1037	CDD:270174	65/199 (33%)
		C2	1079..1187	CDD:301316	38/126 (30%)
		RhoGAP	1203..1398	CDD:295372	88/203 (43%)
bcr	NP_001123792.1	Bcr-Abl_Oligo	3..73	CDD:312543	13/66 (20%)
		SF-CC1	27..>149	CDD:273721	31/151 (21%)
		RhoGEF	392..579	CDD:366202	70/186 (38%)
		PH_BCR_vertebrate	574..767	CDD:270173	65/205 (32%)
		C2_ABR	803..924	CDD:176068	38/126 (30%)
		RhoGAP_Bcr	943..1143	CDD:239852	90/205 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I4645
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1533
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	1	1.000	-	-		FOG0002220
OrthoInspector	1	1.000	-	-		otm48222
Panther	1	1.100	-	-	O	PTHR23182
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	1	1.000	-	-		X2211
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190