DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and arhgap21

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	XP_031759009.1	Gene:	arhgap21 / 100037846	XenbaseID:	XB-GENE-1011028	Length:	1952	Species:	Xenopus tropicalis

Alignment Length:	1569	Identity:	307/1569 - (19%)
Similarity:	519/1569 - (33%)	Gaps:	491/1569 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 CASSNNSNCSSTTNGATQEESNTNLDKD-----FKSSLNLR------------------ESPSST 125
            ||.||  ..|...:|..|.|..:..:::     ...|:.||                  ||...|
Frog    23 CAWSN--QISKNKDGQEQSEMVSPTEEEGFCWPGPKSVALRRASEGFGFTLRHFIVYPPESAVHT 85

  Fly   126 GAKDKD--RLSLN---PDNKYTTHTNAVIGGIGSEKVSGPLHSTQITADGKRTGELYLKREEDKC 185
            ..||::  ...:|   |.|:........:..:   |..||.|..     |..||:..:|
Frog    86 TVKDEENGNRGVNAGRPRNRLEPMDTIFVKQV---KEGGPAHEA-----GLCTGDRIIK------ 136

  Fly   186 KDSNSEDTDGALQQCITELAASLKAQPDNVAGGRLENDVDIDKPLRKSTSQYVTVIQVKEAKDKE 250
              .|.|...|   :..:::.|.::.....:....:..|.||.:.|     |:...:.........
Frog   137 --VNGESVIG---KTYSQVIALIQNSDSTLELSVMPKDEDILQLL-----QFPKDVTALAYSQDA 191

  Fly   251 SADGTTSSSGIGEPQQQPTPPSTFSRYSEATAPPLSPSLTSYAAHVEAKKKMPPRPPPKNIRRVE 315
            ...|..|.|  |..|..|.|            ||:....|..||.|.|:   |...||..
Frog   192 YLKGNDSYS--GNAQNIPEP------------PPICYPRTKPAASVMAQ---PVEVPPSG----- 234

  Fly   316 PPTIPSQQLSSSPKRETYMINTMPSSSSGSLCIDSLGNSLERNIKPS--DILRQKSSDNLDSKYS 378
              |..::|.||.|.|..   .|.|..|          ..:|..:.||  ||::..::..:.:: :
Frog   235 --TSLTKQQSSRPVRTA---TTQPDRS----------YRVEIQVPPSPTDIVKSNTAVCVCNE-A 283

  Fly   379 AKRKTTPELSKFVNVNNPELMEELGRKMVSKADSLEQT-------------RRNDSSPS------ 424
            .:....|.          |.:.:|.....::|..|.:|             :|..|.||
Frog   284 VRTVILPS----------EKVVDLSSNRTNRAGPLHRTEEVRYGLADPSMLKRTTSPPSSTPSVP 338

  Fly   425 ---------GCGSLGRTSSTPGR-----SLTPGRTGVGASPTGSLSKTGKLAMADSSSTSSL--- 472
                     ..|.:|:..|..|.     |..|.:.....|||...:..|.....|..:..:.
Frog   339 MVPASRQFDNAGVIGKPPSYGGHSESMFSTRPSQAEESPSPTNHYASPGSHQQIDWRNYKTYKEY 403

  Fly   473 ---------------ERRSCLQA-----VDADIGTESRESGANQR----------SVGSKESLTS 507
                           ||...|:|     .|.|....:|.||..:|          ||..::...|
Frog   404 IDNRRMQMYGCRTIQERLDSLRAASQNTTDYDQMLPNRSSGQVRRRSTSHDRVPQSVQMRQRSVS 468

  Fly   508 QGISE--VQIKSYESVSSLSSESAKAVASQQSAAAGGALAECEPYYDSVPLD---NGDGEYVFIK 567
            |...|  |.:|.:...:|..:.::..||.:...:........:..:|...:|   ||:.::.:..
Frog   469 QERLEDPVLMKEWPRSASQDTLTSLTVAPRNHRSESWDYLTRKEDFDQFIVDTQSNGEQKHNYKW 533

  Fly   568 PGRTGSSSSRD------------DLSTPGSSILPLPNVADPE-------SPGRTSNYVNIDFFLQ 613
            .|.|.....|.            .|.:|..::.|||..:|..       :|.|....|:.|
Frog   534 TGFTEQDDQRGIYEIPRQHSFHMSLRSPNYTMAPLPYPSDSRRAGTRVLAPARPLQKVHPD---- 594

  Fly   614 QGIETRSSSLDSDGEYEGP------------PILRTISHDDQTTTQTTP---------GAIR-KN 656
              ::|...:.:....|..|            ||.::.|.....|..:.|         |.:: :.
Frog   595 --LKTIQPTRNFQNSYRSPHPRPAVSERLVFPISKSNSVKIPATYASKPYSPSVGSEDGIVKDQK 657

  Fly   657 LVSAILVCG-----------NARGAKIRSILSSIIQSETIYVECLNKMMQYKKAIHATLT----- 705
            .|:.|.|.|           :|.|.::.|:.:|...|.:....    ....|:..|:|.|
Frog   658 AVNYIHVSGPQNFQRKPQTESALGFQLDSLKTSTSASSSSPAH----TKPAKQVKHSTATSQNVD 718

  Fly   706 ---TSQPVIREEEENTIFFKIDELYDLHTGFLSDLKTIVSHE----GGDVLIGEPFRRLAEMF-- 761
               |..|.....:.|::...||:              :|..|    |...  .:|.|:.:.:|
Frog   719 GKKTQSPEANASDSNSVLTSIDQ--------------VVLREKPSPGQQT--SQPIRQPSYIFAV 767

  Fly   762 -DLYSA-----FLHN------YKNAIETVKKCSANNP--------------------QFKKIVST 794
             |:..|     :|.|      :...||..|...:::|                    :...|.::
Frog   768 SDVEGASDTTCWLPNDARREVHIKRIEQKKASGSDSPGDSLASIPFIDEPTSPSIDHEIANIPAS 832

  Fly   795 IVLNLQTEQSLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVV 859
            .|:::..:...|:..:...|.:.|.:....|:.          ||..:|.:  |::        |
Frog   833 AVISISVQPLPTITTVPPSPTSPVPLIRRHFSH----------DHDSIRPS--ILE--------V 877

  Fly   860 NQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLK 924
            |.:..           |:....|.:|                  .||..|:    ..||....||
Frog   878 NSKTE-----------RSKSCDEGLD------------------DYKDEGK----LSLKQGSSLK 909

  Fly   925 DVSIYEEADPAVELKESSPANISQV--------------------KRNLRSVRDQLAMEVANSGS 969
            .:...|.. |:.|..||...:.|.|                    ||...|:|....|.|...||
Frog   910 GIKARENV-PSSEDSESRKDSSSDVFSDSNKEGFLYFRQLTTEKGKRVSGSMRPWKQMYVVLRGS 973

  Fly   970 GAFRSGDK-----YRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFE---RTQWIDSI 1026
            ..:...||     :....:| |.||:.....|:....::...|.:....:||.|   :.:..|.:
Frog   974 ALYLQKDKKEQSGHSSAQSD-EEQLIGINGCLIDISYSETKRKNVFRLTTSDREFLFQAEDRDDM 1037

  Fly  1027 LSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDLYMGVHGLEGLEQ 1091
            |                    |:|.|:|     |.|     |.|||.               .:|
Frog  1038 L--------------------AWIKAIQ-----ENG-----NLNDEQ---------------TDQ 1057

  Fly  1092 ANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAKERPLLKAKHI 1156
            |:.:.|...:..|......::.|.   .|:|..:...:       ::|......|....|::.|.
Frog  1058 ASRVLISKRIKEYNTMMSSSSNKS---EQSPKPSRQTL-------SIRQPFRATKPEGKLQSPHS 1112

  Fly  1157 LKLS----LSWLTETTQPKSIKLTETLELGCSFRFIPGELFRGSTKPGALFGAKMSQV-LKREKR 1216
            .|..    |....:.:.||        :.| |:|.|..:.|......|..||.::... .....:
Frog  1113 PKQESERRLFSKDDISPPK--------DKG-SWRRIMKKPFEKKPTTGGTFGVRLDDCPPAHNNK 1168

  Fly  1217 DIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAE-QLLREVDIHSVTGILK 1280
            .:|.|:..|.:.||.||:...|.|||.|:.:.::.:::.....:.:.: |..:..|::.::.:||
Frog  1169 YVPLIVDVCCKLVEDRGLETTGIYRVPGNNAAISSMQEELNKGSTDIDIQDDKWRDLNVISSLLK 1233

  Fly  1281 TFLRELPEALFTDQLYPRFFDTFSAFSNNNES--TRINELLKVFEELPQANKASITSILDHLIRV 1343
            :|.|:||:.|||::.|..|.:     :|..|.  .|:..|.::..:||..:..::..:..||..|
Frog  1234 SFFRKLPDPLFTNEKYNDFIE-----ANRTEDPVERLKTLKRLILDLPDHHYETLKYLSAHLKAV 1293

  Fly  1344 HEKETDNKMSLHNLAMVFGPTLLR-------------PGQ-----TQVKQKD----------PLA 1380
            .|....|||...|||:||||||:|             |.|     |.::|.|          |:.
Frog  1294 AENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQQHDWFFSEESADEPIT 1358

  Fly  1381 A----STVD 1385
            |    |||:
Frog  1359 AVQEESTVE 1367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	35/227 (15%)
		PH_BCR_arthropod	851..1037	CDD:270174	40/213 (19%)
		C2	1079..1187	CDD:301316	17/111 (15%)
		RhoGAP	1203..1398	CDD:295372	60/219 (27%)
arhgap21	XP_031759009.1	PDZ_signaling	55..165	CDD:238492	23/128 (18%)
		PH_ARHGAP21-like	938..1051	CDD:269955	28/143 (20%)
		RhoGAP_ARHGAP21	1153..1348	CDD:239860	55/199 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940