DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP1A and arhgap15

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_001122027.1	Gene:	arhgap15 / 100003547	ZFINID:	ZDB-GENE-070912-314	Length:	465	Species:	Danio rerio

Alignment Length:	511	Identity:	129/511 - (25%)
Similarity:	210/511 - (41%)	Gaps:	117/511 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   935 AVELK-----ESSPANISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQL-VLAT 993
            ||:|:     .|:...:||.|..:....:.|...:           :::||..:...|:: |...
Zfish    12 AVQLRIKNSQSSTGERLSQTKSMVLPEAETLQKPI-----------NRHRRNQSQHNSEVSVGLQ 65

  Fly   994 PNLVLRLGNKA----------NNKTITF-FLSSD---FERTQWIDSILSLKQKCNLPGANTINSL 1044
            |.|.....|||          .|.|:|: .|||:   |.:....:::.:||     ||... :.:
Zfish    66 PVLKGEYLNKAKIAEGGKKLRKNWTLTWVVLSSNQLLFYKESKQEAVSNLK-----PGGKP-DGV 124

  Fly  1045 EVTAFIVAMQKGMKTEMGS-----YLMRNTNDESLLVGDLYMGV---HGLEGLEQANDL------ 1095
            ::...::.    ..||..|     .:...|..|.||..|.:..:   |  :.:::|.|:
Zfish   125 DLNGAVIE----WTTEKSSRKNVIQITTPTGHEFLLQADHFPTISKWH--DAIKKAVDILSSGSG 183

  Fly  1096 -YICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAKERPLLKA-----K 1154
             ..|.....:.....:..::..|.|..|...|:      .|::.|.::::........|     |
Zfish   184 GQSCGRAALHRSNSTECLSRPTCESSKPKPKET------KSEHRRSIMFKLNYSASDSADKNGVK 242

  Fly  1155 HILKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGELFRGSTKPGALFGAKMSQVLKREKRDIP 1219
            :.||..:|     .:|....|.|                :|..| ..:||..|..:..|||..:|
Zfish   243 NRLKKFIS-----RRPSMKTLQE----------------KGIIK-DRVFGCHMLTLCDREKTTVP 285

  Fly  1220 FIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQL--LREVDIHSVTGILKTF 1282
            ..:..|:.|||:||:...|.|||||:.:.:.||:  |..|..|...|  .:..|||.:||.||.|
Zfish   286 KFVKLCVEEVEKRGLEADGIYRVSGNLAIIQKLR--FLVDQEEELDLGDSQWEDIHVITGALKMF 348

  Fly  1283 LRELPEALFTDQLYP-RFFDTFSAFSNNNEST-RINELLKVFEELPQANKASITSILDHLIRVHE 1345
            .|||||.||     | ||||.|.......|.| ::..:.|:..:||:.|..::..:..||.||..
Zfish   349 FRELPEPLF-----PFRFFDLFVETIKIKEPTQKVQAMKKLIHQLPKPNHNTMKLLFHHLRRVLT 408

  Fly  1346 KETDNKMSLHNLAMVFGPTLLRP----GQTQVKQKDPLAASTVDVMAQAGILYCFL 1397
            |...|.||...:::||||||:.|    |..:           |:::.|..|:.|.|
Zfish   409 KSQKNLMSTQGVSIVFGPTLMWPEFESGNME-----------VNMVYQNQIVECIL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619
		PH_BCR_arthropod	851..1037	CDD:270174	26/121 (21%)
		C2	1079..1187	CDD:301316	18/122 (15%)
		RhoGAP	1203..1398	CDD:295372	73/203 (36%)
arhgap15	NP_001122027.1	PH	67..175	CDD:278594	24/119 (20%)
		PH_ARHGAP9-like	68..176	CDD:270053	25/119 (21%)
		RhoGAP_ARHGAP27_15_12_9	269..453	CDD:239868	72/201 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940