Protein Alignment clos and Tspear

DIOPT Version :9

• Sequence 1: NP_001097246.3
• Gene: clos / 5740204
• FlyBaseID: FBgn0261016
• Length: 1836
• Species: Drosophila melanogaster
• Sequence 2: NP_001274003.1
• Gene: Tspear / 252974
• MGIID: 2671932
• Length: 670
• Species: Mus musculus
• Alignment Length: 455
• Identity: 100/455 - (21%)
• Similarity: 170/455 - (37%)
• Gaps: 159/455 - (34%)

  Fly    28 SYPTHFLNSDQESMLHKRATAVPQFFDQASFSFD----------GLERVASVPVSFPLDICILQL 82
            :||   ..:|.:..|..|......  :.|.|.||          |.|.|:.:.....||.
Mouse   261 NYP---YEADMKVTLGSRPPCTKA--EGAQFWFDAAQKGLYLCAGSEWVSVLAAKTKLDY----- 315

  Fly    83 PTVKYATALHKNAAGVRHFAVYTWRPAEQDYQLLVELETPKAVALDCLAFAGRGYVAVSYNLTEP 147
              |:...:||.|:                           :.:.::..:..|.|..|.:.|
Mouse   316 --VEEHQSLHTNS---------------------------ETLGIEVFSIPGVGLFAAAAN---- 347

  Fly   148 VSQAREGSPIYE------ISPETGIRTVQYFSGTHL---RGMYLRISS-------QELTLLHAFE 196
             .:||  |.||:      :|.: .|.|.|..|..|.   :.::|.:::       ||.:::
Mouse   348 -RKAR--SAIYKWTDGKFVSYQ-NIATHQAQSWRHFTIGKKIFLAVANFGPNERGQEFSVI---- 404

  Fly   197 SNAQCPYFKWMGKS-----FQRLGAIHCSKARRMEAFGIDYTDYVAVANYADAEGRTATHSEIFR 256
                   :||..:.     :||: |.|  .||..|||.:|...::.|||:.:.:... ..|.::|
Mouse   405 -------YKWSPRKLKFTLYQRI-ATH--SARDWEAFEVDGEHFLVVANHREGDNHN-IDSMVYR 458

  Fly   257 WDAKSQRFQLFQRLRSNGAVDVKYFSLPVNEVSRRHFLILGNTIGGTGAEVGDADTVIYVFEKGQ 321
            |:..||.|:..|.:.::||.|.::|:     |....||::.||..||..:|   .:.:|::..|.
Mouse   459 WNPSSQLFEANQSIATSGAYDWEFFT-----VGPYSFLVVANTFNGTSTQV---HSHLYIWLVGA 515

  Fly   322 FVPYQR-LSFYALERVLPVQHSISEKFLLLVA-CNKQDVK-------------IYNLN------- 364
            |..:|. |:|.|.:  ..|.| |.|:..|.|| .:..||:             ||.||
Mouse   516 FQLFQSFLTFGAAD--WEVFH-IGERIFLAVANSHSYDVQMQAQNDSYVLSSVIYELNITAQTFV 577

  Fly   365 -----------DWRFEESKVQFTEGALSRGVARMRSYEEGDQSYLVIANENMAANETNIFQPLYK 418
                       ||.|                     :..|:..:||:|| :...|..::...:|:
Mouse   578 KFQDIPTCSALDWEF---------------------FSVGEDHFLVVAN-SFDGNTFSVNSIIYR 620

  Fly   419  418
            Mouse   621  620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clos	NP_001097246.3	EPTP	263..315	CDD:281697	14/51 (27%)
Tspear	NP_001274003.1	LamG	<84..223	CDD:304605
		EAR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	314..359		14/85 (16%)
		EAR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	361..409		11/59 (19%)
		EPTP	361..408	CDD:281697	10/58 (17%)
		EAR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	413..461		16/51 (31%)
		EPTP	413..460	CDD:281697	15/50 (30%)
		EAR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	465..513		15/55 (27%)
		EPTP	466..511	CDD:281697	15/52 (29%)
		EAR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	515..571		17/58 (29%)
		EPTP	516..>546	CDD:281697	12/32 (38%)
		EAR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	575..623		10/68 (15%)
		EPTP	576..621	CDD:281697	10/67 (15%)
		EAR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	626..669
		EPTP	626..666	CDD:281697

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849230
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto94148
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15261
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940