Protein Alignment Drgx and ALX1

DIOPT Version :10

• Sequence 1: NP_001097075.2
• Gene: Drgx / 5740176
• FlyBaseID: FBgn0085369
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_008913.2
• Gene: ALX1 / 8092
• HGNCID: 1494
• Length: 326
• Species: Homo sapiens
• Alignment Length: 259
• Identity: 82/259 - (31%)
• Similarity: 108/259 - (41%)
• Gaps: 73/259 - (28%)

  Fly    44 DETFVRRKQRRNRTTFTLQQLEELETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWR 108
            |......|:||:|||||..||||||..|.:||||||:.||.||::..||||||||||||||||||
Human   124 DSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWR 188

  Fly   109 KAERLKDEQRKRENGESSSSLDKLHDSRESSPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHS 173
            |.||....|:.:.:..::..:..|                      ||..|:..:.|
Human   189 KRERYGQIQQAKSHFAATYDISVL----------------------PRTDSYPQIQN-------- 223

  Fly   174 HSHSHSHSRSPGGGMHLDSSDNERPLSSNQLTATPHSASQSLGSISAGSPSPSGMHREREHTPLV 238
                :..:.:..||..:.|....|..||   ..||:|.|....|...|.   |....:..|.||
Human   224 ----NLWAGNASGGSVVTSCMLPRDTSS---CMTPYSHSPRTDSSYTGF---SNHQNQFSHVPL- 277

  Fly   239 GGGGQGPSSPSNSRNTDSPIEVGGPMSLTTGSRMAASSNNSASSTPTPTTPHAPQMPHSSAAAA 302
                       |:..||         ||.||     ::|..|..|       .|:....|::.|
Human   278 -----------NNFFTD---------SLLTG-----ATNGHAFET-------KPEFERRSSSIA 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drgx	NP_001097075.2	Homeodomain	53..109	CDD:459649	41/55 (75%)
		OAR	428..446	CDD:461067
ALX1	NP_008913.2	Homeodomain	133..189	CDD:459649	41/55 (75%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	192..326		36/191 (19%)
		OAR	302..320	CDD:461067	2/8 (25%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319		1/4 (25%)