DRSC/TRiP Functional Genomics Resources

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Protein Alignment Drgx and VSX1

DIOPT Version :10

Sequence 1:NP_001097075.2 Gene:Drgx / 5740176 FlyBaseID:FBgn0085369 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_055403.2 Gene:VSX1 / 30813 HGNCID:12723 Length:365 Species:Homo sapiens


Alignment Length:305 Identity:93/305 - (30%)
Similarity:119/305 - (39%) Gaps:99/305 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PALHPCGPHPPRLPTLDYPFAATHPYTSYSYHPAI-----------HDE--------------TF 47
            |.|.|.||.|..      |.|.:.|      .||:           .||              |.
Human   107 PFLPPRGPEPAA------PLAPSRP------PPALGRQKRSDSVSTSDEDSQSEDRNDLKASPTL 159

  Fly    48 VRRKQRRNRTTFTLQQLEELETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAER 112
            .:||:||:||.||..||||||.||::.|||||:.||.||:|..|.|.|:|||||||||||||.| 
Human   160 GKRKKRRHRTVFTAHQLEELEKAFSEAHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKRE- 223

  Fly   113 LKDEQRKRENGESSSS---------------LDKLHDSRESSPDITGEIDDDMDDLPPRQRSHSP 162
                  ||..|.|..:               .|.:.:|.|..  :.|              |.:|
Human   224 ------KRWGGSSVMAEYGLYGAMVRHCIPLPDSVLNSAEGG--LLG--------------SCAP 266

  Fly   163 LANGQMEQQHSHSHSHSHSRSPG---------GGMHL--DSSDNERPLSSNQLTATPHSASQSLG 216
            ...|.      |..|....|.||         |..|.  .||.:|   |.:|..:...|....|.
Human   267 WLLGM------HKKSMGMIRKPGSEDKLAGLWGSDHFKEGSSQSE---SGSQRGSDKVSPENGLE 322

  Fly   217 SISAGSPSPSGMHREREHTPLVGGGGQGPSSPSNSRNTDSPIEVG 261
            .::....|.:....::.|.   |.|.||.|: |.:.....|.:||
Human   323 DVAIDLSSSARQETKKVHP---GAGAQGGSN-STALEGPQPGKVG 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DrgxNP_001097075.2 Homeodomain 53..109 CDD:459649 38/55 (69%)
OAR 428..446 CDD:461067
VSX1NP_055403.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
Octapeptide motif 31..38
PRK14959 <47..>149 CDD:184923 13/53 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 113..167 14/65 (22%)
Nuclear localization signal. /evidence=ECO:0000255 161..166 2/4 (50%)
Homeodomain 165..221 CDD:459649 38/55 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 290..365 20/81 (25%)
Blue background indicates that the domain is not in the aligned region.

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