Protein Alignment Drgx and Pdx1

DIOPT Version :10

• Sequence 1: NP_001097075.2
• Gene: Drgx / 5740176
• FlyBaseID: FBgn0085369
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_074043.4
• Gene: Pdx1 / 29535
• RGDID: 62387
• Length: 283
• Species: Rattus norvegicus
• Alignment Length: 275
• Identity: 66/275 - (24%)
• Similarity: 95/275 - (34%)
• Gaps: 102/275 - (37%)

  Fly     4 YQCPPA--------LH------------PCGPHP----------PRLPTLDYPF---AATHPYTS 35
            |:.||.        ||            |.||.|          |....|.:|:   ...|.:.|
  Rat    68 YEVPPLADDPAGAHLHHHLPAQLGLAHPPPGPFPNGTETGGLEEPSRVHLPFPWMKSTKAHAWKS 132

  Fly    36 ------YSYHPAIHDETFVRRKQRRNRTTFTLQQLEELETAFAQTHYPDVFTREDLAMKINLTEA 94
                  |:..|         .:.:|.||.:|..||.|||..|....|.....|.:||:.:||||.
  Rat   133 QWAGGAYAAEP---------EENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTER 188

  Fly    95 RVQVWFQNRRAKWRKAERLKDEQRKRENGESSSSLDKLHDSRESSPDITGEIDDDMDDLPPRQRS 159
            .:::||||||.||:     |:|.:||.:|.:|..    ....|...|......:::..|||
  Rat   189 HIKIWFQNRRMKWK-----KEEDKKRSSGTTSGG----GGGEEPEQDCAVTSGEELLALPP---- 240

  Fly   160 HSPLANGQMEQQHSHSHSHSHSRSPGGGMHLDSSDNERPLSSNQLTATPHSASQSLGSISAG--- 221
                                 ...|||.:.               :..|.:|.:  |.:.:|
  Rat   241 ---------------------PPPPGGAVP---------------SGVPAAARE--GRLPSGLSA 267

  Fly   222 SPSPSGMHREREHTP 236
            ||.||.:...|...|
  Rat   268 SPQPSSIAPLRPQEP 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drgx	NP_001097075.2	Homeodomain	53..109	CDD:459649	26/55 (47%)
		OAR	428..446	CDD:461067
Pdx1	NP_074043.4	Transactivation domain	13..73		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81		3/12 (25%)
		Antp-type hexapeptide	118..123		1/4 (25%)
		Homeodomain	147..203	CDD:459649	26/60 (43%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/10 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		25/133 (19%)