DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drgx and Alx1

DIOPT Version :9

Sequence 1:	NP_001097075.2	Gene:	Drgx / 5740176	FlyBaseID:	FBgn0085369	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_037053.1	Gene:	Alx1 / 25401	RGDID:	2273	Length:	326	Species:	Rattus norvegicus

Alignment Length:	259	Identity:	82/259 - (31%)
Similarity:	108/259 - (41%)	Gaps:	73/259 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DETFVRRKQRRNRTTFTLQQLEELETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWR 108
            |......|:||:|||||..||||||..|.:||||||:.||.||::..||||||||||||||||||
  Rat   124 DSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWR 188

  Fly   109 KAERLKDEQRKRENGESSSSLDKLHDSRESSPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHS 173
            |.||....|:.:.:..::..:..|                      ||..|:..:.|
  Rat   189 KRERYGQIQQAKSHFAATYDISVL----------------------PRTDSYPQIQN-------- 223

  Fly   174 HSHSHSHSRSPGGGMHLDSSDNERPLSSNQLTATPHSASQSLGSISAGSPSPSGMHREREHTPLV 238
                :..:.:..||..:.|....|..||   ..||:|.|....|...|.   |....:..|.||
  Rat   224 ----NLWAGNTSGGSVVTSCMLPRDASS---CMTPYSHSPRTDSSYTGF---SNHQNQFGHVPL- 277

  Fly   239 GGGGQGPSSPSNSRNTDSPIEVGGPMSLTTGSRMAASSNNSASSTPTPTTPHAPQMPHSSAAAA 302
                       |:..||         ||.||     ::|..|..|       .|:....|::.|
  Rat   278 -----------NNFFTD---------SLLTG-----TTNGHAFET-------KPEFERRSSSIA 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drgx	NP_001097075.2	Homeobox	56..108	CDD:278475	38/51 (75%)
Drgx	NP_001097075.2	OAR	428..445	CDD:281777
Alx1	NP_037053.1	Homeobox	135..188	CDD:278475	38/52 (73%)
		Transactivation domain. /evidence=ECO:0000269\|PubMed:12390248	192..326		36/191 (19%)
		OAR	302..319	CDD:281777	2/8 (25%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920