DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drgx and Rax

DIOPT Version :9

Sequence 1:	NP_001097075.2	Gene:	Drgx / 5740176	FlyBaseID:	FBgn0085369	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_038861.2	Gene:	Rax / 19434	MGIID:	109632	Length:	342	Species:	Mus musculus

Alignment Length:	465	Identity:	125/465 - (26%)
Similarity:	153/465 - (32%)	Gaps:	224/465 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CPPALHPCG---PHPPRLPTLDYPFAAT-----------HPYTSYSYHPA-----IHDETFVRRK 51
            ||.|  |.|   ..||..|.....:.||           .|....|..||     :.:|...::|
Mouse    73 CPKA--PAGGSESSPPAAPGFVPEYEATRPCYPKEQGEARPSPGLSVGPAAGDSKLSEEEPPKKK 135

  Fly    52 QRRNRTTFTLQQLEELETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAERLKDE 116
            .||||||||..||.|||.||.::|||||::||:||.|:||.|.||||||||||||||:.|:|
Mouse   136 HRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKL--- 197

  Fly   117 QRKRENGESSSSLDKLHDSRESSPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHSHSHSHSHS 181
                   |.||.  ||.|                          |||.              |.|
Mouse   198 -------EVSSM--KLQD--------------------------SPLL--------------SFS 213

  Fly   182 RSPGGGMHLDSSDNERPLSSNQLTATPHSASQSLGSISAGSPSPSGMHREREHTPLVGGGGQGPS 246
            |||                       |.||...||:                          ||.
Mouse   214 RSP-----------------------PSSALAPLGT--------------------------GPG 229

  Fly   247 SPSNSRNTDSPIEVG-GPMSLTTGSRMAASSNNSASSTPTPTTPHAPQMPHSSAAAAAAFGSHIF 310
            |.|....:..|:|.. ||                    |.|
Mouse   230 SGSGPPGSALPLEPWLGP--------------------PLP------------------------ 250

  Fly   311 GNFGGGSNASDSNCGFRPVLSEQSAVAAAAAAAAAQRSANHPPLFLPPHLAAQFTHQPLFPGLKG 375
               |||:.|..|..||.|            .......|...||.||        ...||.|||:
Mouse   251 ---GGGATALQSLPGFGP------------PGQGLPASYTPPPPFL--------NSAPLGPGLQ- 291

  Fly   376 VSPFQSLCSCCSLKPPPPPGSSVVAPLSIPVSSSSAASSPESPKSSGQGSVHD--PRSNSVAELR 438
                       .|.|||                    :.|.:|....:.|:.:  ||::|:|.||
Mouse   292 -----------QLGPPP--------------------AYPCAPAFGDKFSLEEAYPRNSSIAALR 325

  Fly   439 RKAQEHSAAL 448
            .||:||..|:
Mouse   326 LKAKEHIQAI 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drgx	NP_001097075.2	Homeobox	56..108	CDD:278475	37/51 (73%)
Drgx	NP_001097075.2	OAR	428..445	CDD:281777	9/18 (50%)
Rax	NP_038861.2	Octapeptide motif	33..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..140		18/68 (26%)
		Homeobox	140..192	CDD:278475	37/51 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..295		41/228 (18%)
		OAR	316..331	CDD:281777	8/14 (57%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	319..332		7/12 (58%)
		Nuclear localization signal. /evidence=ECO:0000255	325..329		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920