Protein Alignment Drgx and DLX5

DIOPT Version :10

• Sequence 1: NP_001097075.2
• Gene: Drgx / 5740176
• FlyBaseID: FBgn0085369
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_005212.1
• Gene: DLX5 / 1749
• HGNCID: 2918
• Length: 289
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 69/312 - (22%)
• Similarity: 113/312 - (36%)
• Gaps: 119/312 - (38%)

  Fly     4 YQCPPALHPCGPHPPRLP-----TLDY------------------------PF----------AA 29
            :|...|:|......|.||     ..||                        |:          |.
Human    21 FQTSAAMHHPSQESPTLPESSATDSDYYSPTGGAPHGYCSPTSASYGKALNPYQYQYHGVNGSAG 85

  Fly    30 THP---YTSYSYHPAIHD--------------------ETFVR------RKQRRNRTTFTLQQLE 65
            ::|   |..|||..:.|.                    |..||      :|.|:.||.::..||.
Human    86 SYPAKAYADYSYASSYHQYGGAYNRVPSATNQPEKEVTEPEVRMVNGKPKKVRKPRTIYSSFQLA 150

  Fly    66 ELETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAERLKDEQRKRENGE-----S 125
            .|:..|.:|.|..:..|.:||..:.||:.:|::||||:|:|.:|.         .:|||     |
Human   151 ALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKI---------MKNGEMPPEHS 206

  Fly   126 SSSLDKLHDSRESSPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHSHSHSHSHSRSPGGGMHL 190
            .||.|.:..:...||.:                 ..|..:.:....|.|:|..:.::||... :|
Human   207 PSSSDPMACNSPQSPAV-----------------WEPQGSSRSLSHHPHAHPPTSNQSPASS-YL 253

  Fly   191 DSSDNERPLSSNQLTATPHSASQSLGSISAGSPSPSGMHREREHTPLVGGGG 242
            ::|            |:.::::.|  ||::..|.|..:    :| ||....|
Human   254 ENS------------ASWYTSAAS--SINSHLPPPGSL----QH-PLALASG 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drgx	NP_001097075.2	Homeodomain	53..109	CDD:459649	21/55 (38%)
		OAR	428..446	CDD:461067
DLX5	NP_005212.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		8/27 (30%)
		DLL_N	32..118	CDD:463567	13/85 (15%)
		Homeodomain	138..194	CDD:459649	21/55 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..251		15/69 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..289		6/22 (27%)