Protein Alignment Drgx and ARX

DIOPT Version :9

• Sequence 1: NP_001097075.2
• Gene: Drgx / 5740176
• FlyBaseID: FBgn0085369
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_620689.1
• Gene: ARX / 170302
• HGNCID: 18060
• Length: 562
• Species: Homo sapiens
• Alignment Length: 425
• Identity: 115/425 - (27%)
• Similarity: 146/425 - (34%)
• Gaps: 214/425 - (50%)

  Fly    44 DETFVRRKQRRNRTTFTLQQLEELETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWR 108
            :|..::|||||.|||||..||||||.||.:||||||||||:|||:::||||||||||||||||||
Human   320 EEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWR 384

  Fly   109 KAERLKDEQRKRENGESSSSLDKLHDSRESSPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHS 173
            |.|:...:..                                   ||......||
Human   385 KREKAGAQTH-----------------------------------PPGLPFPGPL---------- 404

  Fly   174 HSHSHSHSRSPGGGMHLDSSDNERPLSSNQLTATPHSASQSLGSISAGSPSPSGMHREREHTPLV 238
               |.:|..||    :||:|
Human   405 ---SATHPLSP----YLDAS--------------------------------------------- 417

  Fly   239 GGGGQGPSSPSNSRNTDSPIEVGGPMSLTTGSRMAASSNNSASSTPTPTTPHAPQMPHSSAAAAA 303
                                                           |..||.|.:..:..||||
Human   418 -----------------------------------------------PFPPHHPALDSAWTAAAA 435

  Fly   304 AFGSHIFGNFGGGSNASDSNCGFRPVLSEQSAVAAAAAAAAAQRSANHPPLFLPPHL-----AAQ 363
            |                              |.||..:......||:.||...|..|     ||.
Human   436 A------------------------------AAAAFPSLPPPPGSASLPPSGAPLGLSTFLGAAV 470

  Fly   364 FTHQPLFPGLKGVSP-FQSLCSCCSLKPPPPPGSSVVAPLSIPVSSSSAASSPESPKSSGQGSV- 426
            |.| |.|     :|| |..|             .|.:|||:   |:|:||:....|..:.:|:|
Human   471 FRH-PAF-----ISPAFGRL-------------FSTMAPLT---SASTAAALLRQPTPAVEGAVA 513

  Fly   427 -----------HDPRSNSVAELRRKAQEHSAALLQ 450
                       .|.|::|:|.||.||:||:|.|.|
Human   514 SGALADPATAAADRRASSIAALRLKAKEHAAQLTQ 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drgx	NP_001097075.2	Homeobox	56..108	CDD:278475	42/51 (82%)
		OAR	428..445	CDD:281777	9/16 (56%)
ARX	NP_620689.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..81
		GCG-encoded polyalanine repeat	102..111
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..255
		Homeobox	332..385	CDD:395001	43/52 (83%)
		OAR	526..544	CDD:397759	10/17 (59%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	530..543		7/12 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920