DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drgx and Phox2a

DIOPT Version :9

Sequence 1:	NP_001097075.2	Gene:	Drgx / 5740176	FlyBaseID:	FBgn0085369	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_032913.1	Gene:	Phox2a / 11859	MGIID:	106633	Length:	280	Species:	Mus musculus

Alignment Length:	281	Identity:	98/281 - (34%)
Similarity:	125/281 - (44%)	Gaps:	82/281 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PALHPCGPHPPRLPTLDYPFAATH-----PYTS--YSYHP---AIHDETFVRRKQRRNRTTFTLQ 62
            ||....||..|.|.:.:....|..     ||::  |.:.|   .:|:    :|||||.|||||..
Mouse    40 PAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFPEPSGLHE----KRKQRRIRTTFTSA 100

  Fly    63 QLEELETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAERLKDEQ-------RKR 120
            ||:|||..||:|||||::|||:||:||:||||||||||||||||:||.||....:       .|:
Mouse   101 QLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGATGAKK 165

  Fly   121 ENGESSSSLDKLHDSRES----SPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHSHSHSHSHS 181
            .....||..|   ||:||    :||.|..:..     ||.....||..              |.|
Mouse   166 GEARCSSEDD---DSKESTCSPTPDSTASLPP-----PPAPSLASPRL--------------SPS 208

  Fly   182 RSPGGGMHLDSSDNERPLSSNQLTATPHSASQSLGSISAGSPSPSGMHREREHTPLVGGGGQGP- 245
            ..|..   |.|....:||.               |::.||               :.||||.||
Mouse   209 PLPAA---LGSGPGPQPLK---------------GALWAG---------------VAGGGGGGPG 240

  Fly   246 SSPSNSRNTDSPIEVG-GPMS 265
            :..:.......|.|.| ||.|
Mouse   241 TGAAELLKAWQPAEPGPGPFS 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drgx	NP_001097075.2	Homeobox	56..108	CDD:278475	40/51 (78%)
Drgx	NP_001097075.2	OAR	428..445	CDD:281777
Phox2a	NP_032913.1	Homeobox	94..147	CDD:395001	40/52 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..244		35/153 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..280		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910