DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and PPP1R9B

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	NP_115984.3	Gene:	PPP1R9B / 84687	HGNCID:	9298	Length:	817	Species:	Homo sapiens

Alignment Length:	1050	Identity:	192/1050 - (18%)
Similarity:	329/1050 - (31%)	Gaps:	392/1050 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 LMQAPSSGESEPSVNSSLNHSGENSDSGIHTLQ--SHPG-----KG------------------Q 509
            :|:....|...|..::|.:.|.  .::||..|:  ..||     ||                  |
Human     1 MMKTEPRGPGGPLRSASPHRSA--YEAGIQALKPPDAPGPDEAPKGAHHKKYGSNVHRIKSMFLQ 63

  Fly   510 PTPSSENTGSSGGGSGSGQPLYANAP-----------PKPRRINDG---------GY-------- 546
            ...::..:|.:|||:|     .|.||           |:...:|:.         |.
Human    64 MGTTAGPSGEAGGGAG-----LAEAPRASERGVRLSLPRASSLNENVDHSALLKLGTSVSERVSR 123

  Fly   547 --SSPSPEHNEQQQQHPSRRLMSPTQQLYQQQQHQRSQQQQQQQPQQHHAIYDTRTGHVSTALQL 609
              |.|:|........||..||.. |::|:::.....:...::                 :.|.:|
Human   124 FDSKPAPSAQPAPPPHPPSRLQE-TRKLFERSAPAAAGGDKE-----------------AAARRL 170

  Fly   610 QQAQQQYSLDHLEAQFQQQQLDMEEQIARLQQQRAAEEIYGEREMYMAKLMQQRQGPNGTYPTQQ 674
            .:.::        |..|.::||:   :.|......|          :.||     ..:...||..
Human   171 LRQER--------AGLQDRKLDV---VVRFNGSTEA----------LDKL-----DADAVSPTVS 209

  Fly   675 QLLQAERRTPDAYGRSKQQRLFAAAAAAADYEDIYNMSQLAGGGGVPMSA-----QEALLQEAAS 734
            ||                         :|.:|...:.:.|..|.|:|.:|     ...|:.:.:.
Human   210 QL-------------------------SAVFEKADSRTGLHRGPGLPRAAGVPQVNSKLVSKRSR 249

  Fly   735 YRRPLSPPSYDGSKHVPAMPQR-----YTPNHLEASAAD-------------QLINTMDLRARTA 781
            ..:|..||....|...||..:|     ..|.|..|.|..             ::..:.:..|.:|
Human   250 VFQPPPPPPPAPSGDAPAEKERCPAGQQPPQHRVAPARPPPKPREVRKIKPVEVEESGESEAESA 314

  Fly   782 -----AAIVRPHSADFLE-------------YEARAEAAAAAAAAAVAQSQQ--ESGRAP--RPK 824
                 .|.|..|:|  ||             .|.:|:||....|||||..::  .:||||  .|:
Human   315 PGEVIQAEVTVHAA--LENGSTVATAASPAPEEPKAQAAPEKEAAAVAPPERGVGNGRAPDVAPE 377

  Fly   825 SSLDINRTPDSFYYSEASYADKMRKSALYLQSGGAGAAQPQQPGSYRTTGADFNSGVNTIGYENP 889
             .:|.::..|   :|||...|....|.|...|.|:...:..:.        |...|      |.|
Human   378 -EVDESKKED---FSEADLVDVSAYSGLGEDSAGSALEEDDED--------DEEDG------EPP 424

  Fly   890 YERAYKRQELLAEAQGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPPLNVH----PGSIFPPS 950
            ||            ...|...:|.:|.               :::..|...:|    |..:| .:
Human   425 YE------------PESGCVEIPGLSE---------------EEDPAPSRKIHFSTAPIQVF-ST 461

  Fly   951 MSTQEIISKNEQFLRSASARLPKRSGGMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERKREES 1015
            .|.::...:||                 |.|..|.               |.::.|:...:|.|.
Human   462 YSNEDYDRRNE-----------------DVDPMAA---------------SAEYELEKRVERLEL 494

  Fly  1016 MKRLLEWKQRMLQSPLTRKGIQQGGSNMSAMSKLGSNPNILLASTAVASGARYAP---------- 1070
            ....||.....|...:...|   .|::| .:.|||     :...|....||.:..
Human   495 FPVELEKDSEGLGISIIGMG---AGADM-GLEKLG-----IFVKTVTEGGAAHRDGRIQVNDLLV 550

  Fly  1071 QAGKTVLVG-----------NGNGTAQ---GAGNPPSASGI-------------QRSRSESQANV 1108
            :...|.|||           |..|..:   |...|...|.:             ||...|.:
Human   551 EVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQREMMEQR--- 612

  Fly  1109 GPGGVVYNNYSSDDEA----GTVDDDNLYSATAGRSSSSKTTTKATTSQAIVATTTAALAITNLG 1169
                  |..|..|||.    .|.:|:.|.....|..                    .|:.:..|.
Human   613 ------YAQYGEDDEETGEYATDEDEELSPTFPGGE--------------------MAIEVFELA 651

  Fly  1170 SSKNLETPNQTETEATPSSSSTASSTKAKFQLKPILKVHEASKTRIIQVQPK--HLE-ERPKLRL 1231
            .:::..:|...|.|            |...:.|.:...|..::..|.|::.|  .|| |:.:.|:
Human   652 ENEDALSPVDMEPE------------KLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRV 704

  Fly  1232 QLPKAMGNEEEQKQEDEEQENVEAEPVPILPKKTAPKSPQNANYVPVYNNKLVSNYENMEFGKPI 1296
            :..:...:.||.|:..|:.|....|...:            ...|..:..:..:.|:.:
Human   705 EKAQLEQSVEENKERMEKLEGYWGEAQSL------------CQAVDEHLRETQAQYQAL------ 751

  Fly  1297 PESKIPHSNAAITDPEETPMLMQLKLFKEQQDQQKQQQENEEEDLTPTAESKPIPGEEDMGAPKV 1361
             |.|...:...|.|.::    .:::..|::..|::..:|:|            :..:|:|  .|:
Human   752 -ERKYSKAKRLIKDYQQ----KEIEFLKKETAQRRVLEESE------------LARKEEM--DKL 797

  Fly  1362 I-KDQKLESN 1370
            : |..:||.|
Human   798 LDKISELEGN 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068
kmr	NP_001097775.2	PH	372..469	CDD:278594
PPP1R9B	NP_115984.3	PDZ_5	426..489	CDD:375353	16/122 (13%)
		PP1-binding motif. /evidence=ECO:0000250\|UniProtKB:O35274	447..451		0/3 (0%)
		Interaction with RGS2. /evidence=ECO:0000250	480..525		11/48 (23%)
		PDZ	493..582	CDD:214570	19/97 (20%)
		Interaction with TGN38. /evidence=ECO:0000250	595..816		49/290 (17%)
		SMC_prok_B	<649..>812	CDD:274008	36/207 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..165		33/188 (18%)
		Actin-binding. /evidence=ECO:0000250	1..154		33/160 (21%)
		Interaction with D(2) dopamine receptor. /evidence=ECO:0000250	100..371		62/341 (18%)
		Actin-binding. /evidence=ECO:0000250	164..283		31/186 (17%)
		Interaction with ADRA2A, ADRA2B and ADRA2C. /evidence=ECO:0000250	169..255		22/136 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..447		60/277 (22%)
		Interaction with protein phosphatase 1. /evidence=ECO:0000250	417..494		22/142 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2051
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030