Protein Alignment kmr and Pdzph1

DIOPT Version :10

• Sequence 1: NP_001097775.2
• Gene: kmr / 5740131
• FlyBaseID: FBgn0085412
• Length: 3090
• Species: Drosophila melanogaster
• Sequence 2: NP_081277.2
• Gene: Pdzph1 / 69239
• MGIID: 1916489
• Length: 1233
• Species: Mus musculus
• Alignment Length: 1201
• Identity: 220/1201 - (18%)
• Similarity: 391/1201 - (32%)
• Gaps: 368/1201 - (30%)

  Fly  1129 DDNLYSATAGRSSSS----------------KTTTKATTSQAIVATTTAALAITNLGSSKNLETP 1177
            |:|:.::..|:.:||                |:.....|..||.......|.:. :.:.:....|
Mouse    45 DENITASINGKQNSSFLVKNEKQAPSDSTIHKSMENGYTPPAISPQLEEVLPVA-MFNDREKSLP 108

  Fly  1178 NQTETEATPSSSSTASSTKAKF--QLK-PILKVH-EASKTRIIQVQPKHLEERPKLRLQLPKAMG 1238
            .:..||..|::.......|.||  ::| ....|| |.:|:...:...::|.:|     :.|..
Mouse   109 GKITTEDFPNTVEVLKPAKGKFIREVKCGAFNVHVETTKSIFCKTGAQNLTKR-----RCPTC-- 166

  Fly  1239 NEEEQKQEDEEQENVEAEPVPILPKKTAPKSPQNANYVPVYNNKLVSNYENMEFGKPIPESKIPH 1303
                       .::...:.|....|.....|.........:..::.|.|.     :.:..|::|.
Mouse   167 -----------HQHYSVQQVWRGSKSRGHFSKHRTVLAEEFKRRVPSTYR-----RGVSRSEVPS 215

  Fly  1304 SNAAITDPEETPMLMQLKLFKEQQDQQKQQQENEEEDLTPTAESKPIPGEEDMGAPKVIKDQKLE 1368
            .|.:|...|    :|...:.|:|.........|....||          :...|..|...|:..|
Mouse   216 VNISIVGKE----IMVEYISKKQNTFINICHPNSIGKLT----------KHRRGPLKHTTDEPCE 266

  Fly  1369 S-------NEEEQELEDEDDSTACEEYTDDDIDEALAQDDEDEAVVEAVESQELAEERELQQIYV 1426
            |       :.|.|.||::..|:  :.:.|........|.:..:.:|.::.|
Mouse   267 SASQPGINHPENQRLENQHQSS--DAFHDAPCSVNAVQKENSDTIVVSLSS-------------- 315

  Fly  1427 NEPITPTDQQFDESHYLPMTPKKVELGQPGVLTLVSATYAEEEEENHYVEMTKGIQDEDCRSNYE 1491
                 |..::.::.:.||..|...|.|:
Mouse   316 -----PPRREKEKPNTLPSAPDDSEEGE------------------------------------- 338

  Fly  1492 IMCLASTSSSAFKVTTKTEPVYMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTETLKKKTK 1556
                ::||.......|:.:|:                 |.||    .|...|..:.:|||  :|.
Mouse   339 ----SATSPQKVLQITQDKPL-----------------EQHC----FTADSCLPTSSETL--RTT 376

  Fly  1557 KRQGKDMPDILKPAKSALALASDSSDADDESSRQQLEAKKLRSRSRFSLSDTFRPASYYLGASTP 1621
            .....|:        |.::| .||.|.|:|        :|..|..|.:::...:......|.:.|
Mouse   377 SLNNVDL--------SKMSL-EDSRDVDEE--------RKNSSDVRENITPDSQVQPCTAGTNGP 424

  Fly  1622 LNNYAESSDSEILPPPPIPASPPPMEELKTEEIFSSEHYDTVK----RKDSNGKVNLSYEQLP-K 1681
            |     |:.:.|:          |:::....| ||...:.|::    :.|:.|  ....|.|| :
Mouse   425 L-----SAVNSII----------PIQDASGSE-FSPLSFLTLQLLGAKADNMG--CRGEETLPGE 471

  Fly  1682 MHASNTSLNLP----KAVPSPTL----KSSRLSLPDHFTKVRMTPQRLLVPATPPQQHHARTLSD 1738
            .|.|:.||..|    .|.|||.|    :.||.|.|...|....:..:.:......::.|.|.::.
Mouse   472 GHESSNSLLFPVSEQAAKPSPLLSPSHRVSRCSEPVETTGNTFSFSQYIGVEREQEKVHYRLINK 536

  Fly  1739 SNYSCQLTDTSSRTSSDLDLYRRRGQQQRCTSNNSL-------PLSSE-NESVEFRQRSDSELDR 1795
            ::       ..:.:||::....|:..|....:..|.       ||... :.|||:.|..|..  .
Mouse   537 AS-------LHNDSSSNIQPLERKDPQSPAVTIASCSILVPKSPLHGNIHSSVEWNQTEDHA--N 592

  Fly  1796 QRSRRPLSQESISEIESLSEQFEETLSS-------------------HELDTYLSHLHLSTGQAT 1841
            ...|..||:..:..:.|::.:.|::|::                   .|..:||.::.....||.
Mouse   593 HAERAGLSRMEVPVMASITNELEQSLATQNYKESTVDSNSPMAIRNPRESTSYLENVGDDASQAL 657

  Fly  1842 PTSHLLNDANAAAGADILTNLIKPPKTFRNAED---EEQHFYGNIHFLSSTDSIQQLGEAGATAL 1903
            |               ::.|:     ..||.||   |.|:     ...|..|.:|...|:.:..
Mouse   658 P---------------VVKNM-----CHRNFEDLTRENQN-----EICSQMDFLQNSSESTSVG- 696

  Fly  1904 RIIHSRNNSNISTQSAPYYYSELPAPPPLNNQRDIHAHGLNIAHIHNPIDRHQFNVDALVDKDQA 1968
               |       :|:........|.:....|:.||....|||             |......:.|.
Mouse   697 ---H-------TTEKLFLIDKTLASDDDSNSNRDHKTCGLN-------------NFQQEPAECQR 738

  Fly  1969 IDSKNIYCGQKDN--------------------NEKLSNKNLKLNKSVDLPAE--MEGSGSSGGA 2011
            ..|: :||.:..|                    .:.|.::||::|....|..|  :.|..:|.|:
Mouse   739 TTSR-VYCEESGNQRYPTEVSCHPVDILLSPQKQKALKDQNLEINNPRKLSQELALRGGRASDGS 802

  Fly  2012 LNPVVHSYLTTTKNTNLARK--TIGGSN----------PSDDGNPNEDGAGENTEEAGKTPSNNV 2064
            ....:..:....:.....::  :.|||:          .|||.:..:.|...:.||.| ..:.|.
Mouse   803 QEEAIEQWARRRQQFKDGKRCSSAGGSSVISNFTEGSITSDDVHSVDFGFRVDIEEKG-FYTENF 866

  Fly  2065 HTNLSVLGGELLWEEDALWRESLRRVSQRHARSLDDLDRITAAPPISSTPKAKLSREVTYVNDSL 2129
            |:...|..|     :|....:|.|.:|::                    |:....||.| |....
Mouse   867 HSTAWVFRG-----DDGNPEDSPRCLSKK--------------------PRPVAVRERT-VRLFK 905

  Fly  2130 KPRQHP---HITNEHDVYVQLMDTTSSSHDHDQTDSDVY------EVLREETAS--NLSHK---- 2179
            ....:|   .|.....:.|..:||.|::.:......||.      ||...|.|.  :|:.|
Mouse   906 GTGDYPWGFRIQFSKPIVVTEVDTNSAAEEAGLQIGDVVLSVNGTEVTSVEHAEAVHLAKKGLDI 970

  Fly  2180 -----SNELDRETIRQWDAMSSGLMKSNHSG 2205
                 ::::.|.....|......|.|..|||
Mouse   971 LTMVVASDISRCPNTPWPTCRGYLHKRTHSG 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068
Pdzph1	NP_081277.2	PDZ	897..975	CDD:214570	18/78 (23%)
		PH-like	981..1088	CDD:473070	7/21 (33%)
		PH-like	1118..1210	CDD:473070