Protein Alignment kmr and Pdzph1

DIOPT Version :9

• Sequence 1: NP_001097775.2
• Gene: kmr / 5740131
• FlyBaseID: FBgn0085412
• Length: 3090
• Species: Drosophila melanogaster
• Sequence 2: NP_081277.1
• Gene: Pdzph1 / 69239
• MGIID: 1916489
• Length: 1238
• Species: Mus musculus
• Alignment Length: 1201
• Identity: 220/1201 - (18%)
• Similarity: 391/1201 - (32%)
• Gaps: 368/1201 - (30%)

  Fly  1129 DDNLYSATAGRSSSS----------------KTTTKATTSQAIVATTTAALAITNLGSSKNLETP 1177
            |:|:.::..|:.:||                |:.....|..||.......|.:. :.:.:....|
Mouse    50 DENITASINGKQNSSFLVKNEKQAPSDSTIHKSMENGYTPPAISPQLEEVLPVA-MFNDREKSLP 113

  Fly  1178 NQTETEATPSSSSTASSTKAKF--QLK-PILKVH-EASKTRIIQVQPKHLEERPKLRLQLPKAMG 1238
            .:..||..|::.......|.||  ::| ....|| |.:|:...:...::|.:|     :.|..
Mouse   114 GKITTEDFPNTVEVLKPAKGKFIREVKCGAFNVHVETTKSIFCKTGAQNLTKR-----RCPTC-- 171

  Fly  1239 NEEEQKQEDEEQENVEAEPVPILPKKTAPKSPQNANYVPVYNNKLVSNYENMEFGKPIPESKIPH 1303
                       .::...:.|....|.....|.........:..::.|.|.     :.:..|::|.
Mouse   172 -----------HQHYSVQQVWRGSKSRGHFSKHRTVLAEEFKRRVPSTYR-----RGVSRSEVPS 220

  Fly  1304 SNAAITDPEETPMLMQLKLFKEQQDQQKQQQENEEEDLTPTAESKPIPGEEDMGAPKVIKDQKLE 1368
            .|.:|...|    :|...:.|:|.........|....||          :...|..|...|:..|
Mouse   221 VNISIVGKE----IMVEYISKKQNTFINICHPNSIGKLT----------KHRRGPLKHTTDEPCE 271

  Fly  1369 S-------NEEEQELEDEDDSTACEEYTDDDIDEALAQDDEDEAVVEAVESQELAEERELQQIYV 1426
            |       :.|.|.||::..|:  :.:.|........|.:..:.:|.::.|
Mouse   272 SASQPGINHPENQRLENQHQSS--DAFHDAPCSVNAVQKENSDTIVVSLSS-------------- 320

  Fly  1427 NEPITPTDQQFDESHYLPMTPKKVELGQPGVLTLVSATYAEEEEENHYVEMTKGIQDEDCRSNYE 1491
                 |..::.::.:.||..|...|.|:
Mouse   321 -----PPRREKEKPNTLPSAPDDSEEGE------------------------------------- 343

  Fly  1492 IMCLASTSSSAFKVTTKTEPVYMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTETLKKKTK 1556
                ::||.......|:.:|:                 |.||    .|...|..:.:|||  :|.
Mouse   344 ----SATSPQKVLQITQDKPL-----------------EQHC----FTADSCLPTSSETL--RTT 381

  Fly  1557 KRQGKDMPDILKPAKSALALASDSSDADDESSRQQLEAKKLRSRSRFSLSDTFRPASYYLGASTP 1621
            .....|:        |.::| .||.|.|:|        :|..|..|.:::...:......|.:.|
Mouse   382 SLNNVDL--------SKMSL-EDSRDVDEE--------RKNSSDVRENITPDSQVQPCTAGTNGP 429

  Fly  1622 LNNYAESSDSEILPPPPIPASPPPMEELKTEEIFSSEHYDTVK----RKDSNGKVNLSYEQLP-K 1681
            |     |:.:.|:          |:::....| ||...:.|::    :.|:.|  ....|.|| :
Mouse   430 L-----SAVNSII----------PIQDASGSE-FSPLSFLTLQLLGAKADNMG--CRGEETLPGE 476

  Fly  1682 MHASNTSLNLP----KAVPSPTL----KSSRLSLPDHFTKVRMTPQRLLVPATPPQQHHARTLSD 1738
            .|.|:.||..|    .|.|||.|    :.||.|.|...|....:..:.:......::.|.|.::.
Mouse   477 GHESSNSLLFPVSEQAAKPSPLLSPSHRVSRCSEPVETTGNTFSFSQYIGVEREQEKVHYRLINK 541

  Fly  1739 SNYSCQLTDTSSRTSSDLDLYRRRGQQQRCTSNNSL-------PLSSE-NESVEFRQRSDSELDR 1795
            ::       ..:.:||::....|:..|....:..|.       ||... :.|||:.|..|..  .
Mouse   542 AS-------LHNDSSSNIQPLERKDPQSPAVTIASCSILVPKSPLHGNIHSSVEWNQTEDHA--N 597

  Fly  1796 QRSRRPLSQESISEIESLSEQFEETLSS-------------------HELDTYLSHLHLSTGQAT 1841
            ...|..||:..:..:.|::.:.|::|::                   .|..:||.::.....||.
Mouse   598 HAERAGLSRMEVPVMASITNELEQSLATQNYKESTVDSNSPMAIRNPRESTSYLENVGDDASQAL 662

  Fly  1842 PTSHLLNDANAAAGADILTNLIKPPKTFRNAED---EEQHFYGNIHFLSSTDSIQQLGEAGATAL 1903
            |               ::.|:     ..||.||   |.|:     ...|..|.:|...|:.:..
Mouse   663 P---------------VVKNM-----CHRNFEDLTRENQN-----EICSQMDFLQNSSESTSVG- 701

  Fly  1904 RIIHSRNNSNISTQSAPYYYSELPAPPPLNNQRDIHAHGLNIAHIHNPIDRHQFNVDALVDKDQA 1968
               |       :|:........|.:....|:.||....|||             |......:.|.
Mouse   702 ---H-------TTEKLFLIDKTLASDDDSNSNRDHKTCGLN-------------NFQQEPAECQR 743

  Fly  1969 IDSKNIYCGQKDN--------------------NEKLSNKNLKLNKSVDLPAE--MEGSGSSGGA 2011
            ..|: :||.:..|                    .:.|.::||::|....|..|  :.|..:|.|:
Mouse   744 TTSR-VYCEESGNQRYPTEVSCHPVDILLSPQKQKALKDQNLEINNPRKLSQELALRGGRASDGS 807

  Fly  2012 LNPVVHSYLTTTKNTNLARK--TIGGSN----------PSDDGNPNEDGAGENTEEAGKTPSNNV 2064
            ....:..:....:.....::  :.|||:          .|||.:..:.|...:.||.| ..:.|.
Mouse   808 QEEAIEQWARRRQQFKDGKRCSSAGGSSVISNFTEGSITSDDVHSVDFGFRVDIEEKG-FYTENF 871

  Fly  2065 HTNLSVLGGELLWEEDALWRESLRRVSQRHARSLDDLDRITAAPPISSTPKAKLSREVTYVNDSL 2129
            |:...|..|     :|....:|.|.:|::                    |:....||.| |....
Mouse   872 HSTAWVFRG-----DDGNPEDSPRCLSKK--------------------PRPVAVRERT-VRLFK 910

  Fly  2130 KPRQHP---HITNEHDVYVQLMDTTSSSHDHDQTDSDVY------EVLREETAS--NLSHK---- 2179
            ....:|   .|.....:.|..:||.|::.:......||.      ||...|.|.  :|:.|
Mouse   911 GTGDYPWGFRIQFSKPIVVTEVDTNSAAEEAGLQIGDVVLSVNGTEVTSVEHAEAVHLAKKGLDI 975

  Fly  2180 -----SNELDRETIRQWDAMSSGLMKSNHSG 2205
                 ::::.|.....|......|.|..|||
Mouse   976 LTMVVASDISRCPNTPWPTCRGYLHKRTHSG 1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068
		PH	372..469	CDD:278594
Pdzph1	NP_081277.1	PDZ_signaling	903..981	CDD:238492	17/78 (22%)
		PH-like	986..1093	CDD:302622	7/21 (33%)
		PH	993..1094	CDD:278594	5/14 (36%)
		PH-like	1123..1215	CDD:302622
		PH	1125..1216	CDD:278594

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2051
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940