DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kmr and plekha5

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	XP_021330752.1	Gene:	plekha5 / 567300	ZFINID:	ZDB-GENE-041210-25	Length:	1398	Species:	Danio rerio

Alignment Length:	1855	Identity:	349/1855 - (18%)
Similarity:	582/1855 - (31%)	Gaps:	739/1855 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 SEHGTVYIQQNHPN-----HVVNQACQTQISAVKPKATPSSEES-SSNST---------KSPSHA 345
            |:...:::...|.|     |.|.....|:....:.|..|:|..| :||.|         .||:..
Zfish    93 SQDNCIFVVNEHLNCGNLVHPVLSRPATKAPEAEKKERPTSTMSEASNYTGGSDYTTHPSSPTTR 157

  Fly   346 PLDRKKSAGSIQALKSPITKRPPSTPVTLSGWLHKQGSDGLKVWRKRWFVLAEYCLYYYKGPEEE 410
            |....|...:. ..:|...||.|:.||..:||||||.|.|:|:|:||||||::.||:||:..:||
Zfish   158 PSRSSKKVHNF-GKRSNSIKRNPNAPVIKNGWLHKQDSTGMKMWKKRWFVLSDMCLFYYRDEKEE 221

  Fly   411 KLLGSVLLPSYRVSACLPEDKIYRKFAFKCEHQNMRTYWLAADNSEAMMQWVRALAAASLMQAPS 475
            .:|||:||||:.:|....:|.|.||:|||..|.|||||:.:.|.::.|..|::.::.|::
Zfish   222 GILGSILLPSFHISMLSVDDHITRKYAFKATHPNMRTYYFSTDTAKDMESWMKVMSDAAM----- 281

  Fly   476 SGESEP---------------SVNSSLNH------SGENSDSGIHTLQSHPGKGQPTPSSENTGS 519
             ..|||               .:|:.|||      ..:|::....||:....|.:|:
Zfish   282 -AHSEPIRRLEKVKLDSRVPQEMNNMLNHRVLTRPEIQNNERNRETLRQEDKKSKPS-------- 337

  Fly   520 SGGGSGSGQPLYANAPPKPRRINDGGYSSPSPEHNEQQQQHPSRRLMSPTQQLYQQQQHQRSQQQ 584
                            .||::..|                           ::..|:..:|..:.
Zfish   338 ----------------EKPQKDKD---------------------------RVSMQKDGERFSEN 359

  Fly   585 QQQQPQQHHAIYDTRTGHVSTALQLQQAQQQYSLDHLEAQFQQQQLDMEEQIARLQQQRAAEEIY 649
                       |..|          |:..::|.|          |.|:|:.:.:...::.|.:..
Zfish   360 -----------YTHR----------QKDGERYML----------QKDLEKFVLQKDGEKYAVQKE 393

  Fly   650 GEREMYMAKLMQQRQG------PNGTYPTQQQLLQAERRTPDAYGRSKQQRLFAAAAAAADYEDI 708
            |:      |.:.|:.|      .:|...|.|:.|:......||....::...|:..
Zfish   394 GD------KYLLQKDGHKYTVHKDGDKYTLQRELEMYNPPKDAEKIPQKDARFSLV--------- 443

  Fly   709 YNMSQLAGGGGVPMSAQEALLQEAASYRRPLSPPSYDGSKHVPAMPQRYTPNHLEASAADQLINT 773
              ..:|......|.|.::...|:..:..|||:.                             ||:
Zfish   444 --QKELEKPVPPPRSEEKYGFQKEGTIERPLTK-----------------------------INS 477

  Fly   774 MDLRARTAAAIVRPHSADFLEYEARAEAAAAAAAAAVAQSQQESGRAPRPKSSLDINRTPDSFYY 838
            :.|:                      .|.|||.||||:.|:.
Zfish   478 IKLQ----------------------PAQAAAIAAAVSSSRM----------------------- 497

  Fly   839 SEASYADKMRKSALYLQSGGAG-AAQPQQPGSYRTTGADFNSGVNTIGYENPYERAYKRQELLAE 902
                    |:|     |..|:| .|..:.||...|.
Zfish   498 --------MQK-----QVNGSGERAGDRSPGDLSTV----------------------------- 520

  Fly   903 AQGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPPLNVHPGSIFPPSMSTQEIISKNEQFLRSA 967
                 .:|:|..::.|.:.....|:..|.||                          .||::|:.
Zfish   521 -----RTSVPPPTQPAPEPERSLSRTSSMQQ--------------------------LEQWVRTH 554

  Fly   968 SARLPKRSGGMDDDYSAGNSTTTSPTGGAGASNSPQHNL-------DGERK-------------- 1011
            ..|.|      |||..:..|..|.|      .|.|.|..       :|.|.
Zfish   555 RTRAP------DDDTRSITSYQTLP------RNMPSHRAQIVPRYPEGYRTLPRNMLRPDSICSV 607

  Fly  1012 --------------------REESMKRLLEWKQRMLQSPLTRKGIQQGGSNMSAMSKLGSNPNIL 1056
                                |:::|.:|.||:||...|.|       |...:.:...:|.
Zfish   608 AGSVYDRALQPSTQEKRRSIRDDTMWQLYEWQQRQAHSRL-------GYGTLPSPKTMGQ----- 660

  Fly  1057 LASTAVASGARYAPQAGKTVLVGNGNGTAQGAGNPPSASGIQRSRSESQANVGPGGVVYNNYSSD 1121
                 :|.....:|..|.  |.|....:.....||.       ||||..:.|..|.|
Zfish   661 -----IAESIPTSPSHGS--LAGYHTFSPNRPLNPD-------SRSELSSPVFRGDV-------- 703

  Fly  1122 DEAGTVDDD-----NLYSATAGRSSSSKTTTKATTSQAIVATTTAALAITNLGSSKNLETPNQTE 1181
                |::..     :.||..|.|.:
Zfish   704 ----TIERRHRPHLSKYSYPAERRA---------------------------------------- 724

  Fly  1182 TEATPSSSSTASSTKAKFQLKPILKVHEASKTRIIQVQPKHLEERPKLRLQLPKAMGNEEEQKQE 1246
              |.|:.:.||.|                       :|.|..||...|.::|      ..:|.:.
Zfish   725 --APPAQNITAQS-----------------------LQGKTPEELTLLLIKL------RRQQAEL 758

  Fly  1247 DEEQENVEAEPVPILPKKTAPKSPQNANYVPVYNNKLVSNYENMEFGKPIPESKIPHSNAAITDP 1311
            :..:|:..|:.:.:....|.|||       .:.::.|..|...:       :|::         .
Zfish   759 NSLREHTLAQLMQLNLDATNPKS-------EILSHHLQRNLMYL-------DSQM---------K 800

  Fly  1312 EETPMLMQLKLFKEQ---QDQQKQQQENEEEDLTPTAESKPIPGEEDMGAPKVIKDQKLESNEEE 1373
            |..|::..:....|.   :.|..|||.:.||....|...:|
Zfish   801 ENEPIIFMIHTMIENSAPRPQLYQQQMSPEEYRENTYMYRP------------------------ 841

  Fly  1374 QELEDEDDSTACEEYTDDDIDEALAQDDEDEAVVEAVESQELAEERELQQIYVNEPITPTDQQFD 1438
            :||               |:|..|::..|.:.||.       .:|.:|||::            .
Zfish   842 EEL---------------DVDAKLSRLCEQDKVVR-------TQEEKLQQLH------------R 872

  Fly  1439 ESHYLPMTPKKVELGQPGVLTLVSATYAEEEEENHYVEMTKGIQDEDCRSNYEIMCLASTSSSAF 1503
            |.|.|.             ..|:||:...|....:...:...:|..|...:    .|.||.....
Zfish   873 EKHTLE-------------TALLSASQEIEMSSENPAAVQSVVQQRDVLQS----GLLSTCRELS 920

  Fly  1504 KVTTKTEPVYMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTETLKKKTKKRQGKDMPDILK 1568
            :|:|:.|..:.|...::|...:..|         :.|::.:..|:               |....
Zfish   921 RVSTELERSWREYDRLEADVTLAKT---------NLLEQLEALGS---------------PQTEP 961

  Fly  1569 PAKSALALASDSSDADDESSRQQLEAKKLRSRSRFSLSDTFRPASYYLGAS--TPLNNYAESSDS 1631
            |::..:.:..:.....|     .:||.......|       .|...:.||:  :.|:...:|.||
Zfish   962 PSQKHVQIQKELWRIQD-----VMEALSKNKPKR-------NPEPSFPGANPLSTLHKSEDSVDS 1014

  Fly  1632 EILPP-PPIPAS------PPPM----------------EELKTEE-----------IFSSE-HYD 1661
            ..:|| ||:|.|      |||:                |:.||.:           ::.|| ...
Zfish  1015 SCVPPRPPLPYSYEGGDRPPPLPNPGQPHTTRTTPHRPEDRKTAQRNGTHTGPDYRLYKSEPELT 1079

  Fly  1662 TVKRKD-SNG--KVNLSYEQLPKMHASNTSLNLPKAVPSPTLKSSRLSLPDHFTKVRMTPQRLLV 1723
            ||...| |||  |...:.|:.|.  .....:..|..|.||..||   .:|:..|.......|...
Zfish  1080 TVAEVDESNGEDKSEQTAEKEPP--GVTKGIVYPVGVVSPRTKS---PMPESSTIASYVTLRKTK 1139

  Fly  1724 PATP----PQQHHARTLSDSNYSCQLTDTSSRTSSDLDLYRRRGQ---QQRCTSNNSL------- 1774
            ...|    ||......:...:...::..|.......::..||..|   ::|...:.||
Zfish  1140 KPDPRTCQPQDRPRSAVEQMSSGAEVGRTRMSVEEQMERIRRHQQGALRERRREDGSLSRSLSFT 1204

  Fly  1775 --------------PLSSENESVEFRQRSDSELDRQRSRRPLSQESISEIESLSEQFEETLSSHE 1825
                          |:.|.:|..|.|..:..|.|.:.::.|.::|:..:.       :|.|.:|
Zfish  1205 KDSTYYTLQARKKSPVISPDEQDERRDMTPVERDTKHTKHPDAEENCRDT-------KEQLPAH- 1261

  Fly  1826 LDTYLSHLHLS-----TGQATPTSHLLN-------------------DANAAAGADILTNLIKPP 1866
                 :||.:.     |...:....||.                   |...|....:.|.::...
Zfish  1262 -----THLEIKDKASVTRSVSMKESLLKSVSPKPVLKQDESECKLEYDRKLATQNSLQTAVMVRV 1321

  Fly  1867 KTFRNAEDEEQHFYGNIHFLSSTDSIQQLGEAGATALRIIHSRNNSNISTQ------SAPYYYSE 1925
            .|..:.||||:         ...||:||..:    :..:.:|::::.||..      |:|...|:
Zfish  1322 GTEEDEEDEEE---------EQKDSVQQQED----SYELSNSKHSTLISASCDRKNTSSPSSSSD 1373

  Fly  1926 LPAPPPLNNQRDIHAHGLNIAHIHNPIDRHQFNVD 1960
            ..:.|.|:          .:.:.:....|.|||.|
Zfish  1374 WKSRPLLH----------QLPNTNTTASRPQFNSD 1398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	50/102 (49%)
kmr	NP_001097775.2	PH	372..469	CDD:278594	47/96 (49%)
plekha5	XP_021330752.1	WW	13..42	CDD:306827
		WW	58..87	CDD:306827
		PH_PEPP1_2_3	177..280	CDD:270068	50/102 (49%)
		SMC_N	822..>983	CDD:330553	43/264 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I5711
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24587
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12752
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.100