DRSC/TRiP Functional Genomics Resources

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Protein Alignment kmr and plekhh1

DIOPT Version :9

Sequence 1:NP_001097775.2 Gene:kmr / 5740131 FlyBaseID:FBgn0085412 Length:3090 Species:Drosophila melanogaster
Sequence 2:NP_001070987.1 Gene:plekhh1 / 565914 ZFINID:ZDB-GENE-061219-1 Length:1433 Species:Danio rerio


Alignment Length:1545 Identity:294/1545 - (19%)
Similarity:497/1545 - (32%) Gaps:559/1545 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1175 ETPNQTETEATPSSSSTASSTKAKFQLKPILKVHEASKTRIIQVQPKHLEERPKLRLQLPKAMGN 1239
            |......|...|:||       ..:|.:.|     |.:|:::           :.|||    .||
Zfish     3 EVMESVSTAVVPNSS-------VDWQKRCI-----ALETQLM-----------RFRLQ----AGN 40

  Fly  1240 EEE---QKQEDEEQENVEAEPVPILPKKTAPKSPQNANYVPVYNNKLVSNYENMEFGKPIPESKI 1301
            ...   ::.::.||..:||:              |.|              |:.|....|.|.|:
Zfish    41 IRHLLAERMQELEQRVIEAD--------------QRA--------------ESAEKQVHIMEEKL 77

  Fly  1302 PHSNAAITDPEETPMLMQLKLFKEQQDQQKQQQENEEEDLTPTAESKPIPGEEDMGAPKVIKDQK 1366
            ..:|   ..|.||    :..|::..|:...|.|   |:||                   ::|  :
Zfish    78 KSAN---MQPSET----ENSLYRSYQELSNQIQ---EKDL-------------------IVK--R 111

  Fly  1367 LESNEEEQELEDEDDSTACEEYT---DDDIDEALAQ-DDEDEAVVEA--VESQELAEERELQQIY 1425
            ||...|:|.|....::...||..   .|.:...|.: :.|::.:.:|  .:::::...::..|..
Zfish   112 LEGQLEKQNLVRAQEAEIIEEKAAKIKDWVTFKLREMETENQQLKKANLKQTEQILMLQDKLQTL 176

  Fly  1426 VNEPITPTDQQFDESHYLPMTPKKVELGQPGVLTLVSATYAEEEEENHYVEMTKGIQDE-----D 1485
            :..|::|.    .::|.:|.:|.... ..||                     |...|::     .
Zfish   177 LERPMSPA----VDTHLVPSSPLHPP-SCPG---------------------TPPAQEDCWRLPG 215

  Fly  1486 CRSNYEIMCLASTSSSAFKVTTKTEPVYMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTET 1550
            ||.|       |::.|..|:|...:..:      .::|.:|..::      ::...|..:.|.:.
Zfish   216 CRLN-------SSADSKRKITEGCDSAF------HSASLLPMLQD------KADSPKSSQDGVDA 261

  Fly  1551 LKKKTKKRQGKDMPDILKPAKSALALASDSSDADDESSRQQLEAKKLRSRSRFSLS-----DTFR 1610
            .....:..:|.: |........|:..|||...:.||.: .:..::.|||.|..|.|     :|..
Zfish   262 TSTVKESAEGVE-PSFGVMRDRAMGGASDRDHSSDELN-SKFRSQCLRSSSSSSSSSSSAYETPG 324

  Fly  1611 PASYYLGASTPLNNYAESSDSEILPPPPIPASPP--------------------PMEELKTEEIF 1655
            |..:.....||.:            |||:..|||                    .:.:::| .:.
Zfish   325 PGGFDTPTPTPKS------------PPPVSLSPPLTRLPLSCPFPLALPLGTSMTLPKVRT-PLT 376

  Fly  1656 SSEHYDTVKRKDSNGKVNLSYEQLPKMHASNTSLNL------------PKAVPSPTLKSSRL--- 1705
            ..:....||:..|..:..|.     ::|..|.|:::            |.:.||..|:.:.:   
Zfish   377 PRDSIQLVKKHHSQPQPGLE-----RLHQVNVSIDIGNCGSPSCHSLVPGSAPSHGLEETDIDEG 436

  Fly  1706 ----------------------SLPDHFTK-VRMTPQRLLVPATPPQQHHARTLSDSNY------ 1741
                                  .|.|..|| :.|.....|.|.||| .|...:.....|      
Zfish   437 TPESMEVVVEGSEITEAQPNDGDLLDGLTKELEMMDPEALKPPTPP-LHRFPSWESRIYAVAKLG 500

  Fly  1742 -----SCQLTDTSSRTSSDLD----------LYRR---------RGQQQRCTSNNSLPL-----S 1777
                 :|....|..|.|:...          :|:.         :|   :.|..:|:||     .
Zfish   501 MRVSEACLGAKTIGRVSTQPQHSTTGPFTHLIYKNISVPVYSTLKG---KATQISSVPLPDDDSG 562

  Fly  1778 SENESVEFRQRSDSEL--DRQRS--------RRPLSQESIS---------EIESLSEQFEETLSS 1823
            ||::|........|.|  |::.|        :|.:|..|||         :..||.....|  ..
Zfish   563 SEDDSSSLASLHTSTLGPDKKGSTPGSPRAVKRGVSTSSISSESDYAIPPDAYSLDSDCSE--PE 625

  Fly  1824 HELDTYLSHLHLSTGQAT--PTSHLLNDANAAAGADILTNLIKPPK----TFRNAEDEEQHFYGN 1882
            |::....|:...|.|..|  .|.:||.          :.:.:|..|    ..||.|        .
Zfish   626 HKVQRTSSYSCESVGPETLEKTGYLLK----------MGSQVKAWKRRWFILRNGE--------I 672

  Fly  1883 IHFLSSTDSIQQ--------------LGEAGATALRIIHSRNNSNISTQSAPYYYSELPAPPP-- 1931
            :::.|.:|.|::              .|| ||...::|         |:...:|   |.|..|  
Zfish   673 LYYKSPSDVIRKPQGQMELNSSCHIARGE-GAQTFQLI---------TEKKTFY---LAADSPNI 724

  Fly  1932 -------LNNQRDIHAHGLNIAHIHNPIDRHQFNVDALVDKD------------QAIDSKNIYCG 1977
                   |.|...:.|.|        ||.         :||:            :...||.::|.
Zfish   725 LEDWIRVLQNVLKVQASG--------PIS---------MDKEVKPTARGWLTKVKHGHSKLVWCA 772

  Fly  1978 --------QKDNNEKLSNKNLK--------LNKSVDLPAEME--GSGSSGGALNPVVH------S 2018
                    .::..:|.....|:        :::|.|...:.|  |.|........|||      :
Zfish   773 LIGKVFYYYRNQEDKFPLGQLRVREARVEEVDRSCDSDEDYEAGGRGFLSSHFTLVVHPKEQSPT 837

  Fly  2019 YLTT----TKNTNLARKTIGGSNPSDDGNPNEDGAGENTEEAGKTPSNNVHTNLSVLGGELL--- 2076
            ||..    .|:|.|...|:.                     ||.:.|..|.|....|.|:||   
Zfish   838 YLLVGTKQEKDTWLYHLTVA---------------------AGSSASLRVGTEFEQLIGKLLDVD 881

  Fly  2077 -WEEDALWRESLRRVSQRHARSLDDLDRITAAPPISSTPKAKLSREV--------TYVN------ 2126
             ..:.|||:..:...|:...|.           |:::.|...|..|.        .::|      
Zfish   882 GVSDSALWKREVLCFSKEGLRY-----------PLTTLPSEALQTEAIKLFKSCQLFINVLVESP 935

  Fly  2127 -----DSLKPR------QHPHITNEHDVYVQLMDTTSSSHDHDQTDSDVYEVLREETASNL-SHK 2179
                 .||...      .||.:.||  :|.||:..|:....|:...:..:::|....|..| .|.
Zfish   936 SIDYHTSLAQNALQVCLTHPELQNE--MYCQLIKQTNCRTPHNYALTQCWQLLSLCVALFLPQHH 998

  Fly  2180 SNELDRETIRQWDAMSSGLMKSNHSGVEATGASSAHLPLTSSVRSIVQQLNNSSMDDANGNPMAT 2244
            .    ...:||:       ::.|.......|..:.:..     ||:.:.|.|... :|..:.|..
Zfish   999 F----LWYLRQY-------LQRNADPRTEVGKYAVYCQ-----RSVERTLQNGER-EAKPSRMEI 1046

  Fly  2245 ASISVRNV--NNLPVGNLTVKPDPSDVHQESAFAPYYGGAAETKYAKNTVLTDRGLYAANGSGLA 2307
            .||.:||.  ::||..      .|......:.....:.|:...:...|||....|:.....||.|
Zfish  1047 LSILLRNPYHHSLPFS------IPVHFMNNTYEVVGFDGSTTVEEFLNTVNQRTGMRKPQISGFA 1105

  Fly  2308 TST-------------PQN---------HQQFRMRHTGSRAEIDMLERETSSQIRNRLRS----- 2345
            ..|             |.|         .|..:..|.|        :.|.:..:|...:|     
Zfish  1106 LFTDDPSGKDLEHCLQPANKICDVISKWEQALKELHPG--------KYEGTRTVRLTYKSRLCFR 1162

  Fly  2346 --AEGLTRAESIQRLDYLKQHLLD--LERHYEKSKPL---VNLVDNMVKLGSLYRNDAN--GRVQ 2401
              |:|.|..|.:    .|...:.|  |:.|:..||.|   |..:...|:.|.|.|...:  |..|
Zfish  1163 AQAKGETERERL----LLAYQVNDEVLQGHFPVSKELALEVAALMAQVEYGDLDRAAMSPVGSPQ 1223

  Fly  2402 PATLDRLEFNQRMQEQQMLQEEQQQWERLSPN--QAELQVRELYQLDQLL 2449
            |.|           :|.:|    |..||..|.  :.|..|.:|.:|.:.|
Zfish  1224 PKT-----------QQTLL----QVLERFYPKRYKQECSVEQLRELGERL 1258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kmrNP_001097775.2 PH_PEPP1_2_3 366..469 CDD:270068
PH 372..469 CDD:278594
plekhh1NP_001070987.1 GBP_C <47..156 CDD:303769 33/167 (20%)
coiled coil 145..156 CDD:293879 2/10 (20%)
PH 644..737 CDD:278594 23/123 (19%)
PH1_PLEKHH1_PLEKHH2 646..741 CDD:241436 23/125 (18%)
PH 755..854 CDD:214574 18/98 (18%)
MyTH4 896..1050 CDD:214535 33/183 (18%)
B41 1063..1293 CDD:214604 49/223 (22%)
FERM_M 1168..1293 CDD:278785 29/110 (26%)
FERM_C-lobe_PLEKHH1_PLEKHH2 1289..1390 CDD:241360
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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