DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and acap2a

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	XP_005163306.1	Gene:	acap2a / 564814	ZFINID:	ZDB-GENE-081104-34	Length:	824	Species:	Danio rerio

Alignment Length:	847	Identity:	161/847 - (19%)
Similarity:	290/847 - (34%)	Gaps:	235/847 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 AGRLH--ANNAMAGHHPISALQSQYQQLQAAKMQAQMATQSEAAQQQQRTFALRQAMNPPTNHYH 179
            |||::  ||..........||||...::    :.:.:|..||..|:.              |:||
Zfish    48 AGRVYNQANKQFVNGIRDLALQSTRDEV----IGSSLAAFSETLQEM--------------NNYH 94

  Fly   180 MSQSSSMVSTMTALNQQQQQQQQQQQQQQQQQRAPPSSLNLQNQYQPAQGPLKLQQQQQQQQQQS 244
                       |.|..|.|:..:.|               ||...:......|..::|..:..:.
Zfish    95 -----------TILFDQAQRSIRSQ---------------LQTFVKEDLRKFKDAKKQFDKVSEE 133

  Fly   245 QQPAMPKHYQEQLYAQQQQLQQQLHQQQQQQQQLQQQQQQHRH--------------KNDLQTPG 295
            ::.|:.|:.|..        :.:||:.::....|...|:..|:              |..|:...
Zfish   134 KEVALVKNAQVP--------RNKLHEVEEATNILTTTQKFFRNIALDYVLQINVLQSKRRLEILK 190

  Fly   296 S-----EHGTVYIQQNHPNHVVNQACQTQISA-VKPKATPSSEESSSNSTKSPSHAPLDRKKSAG 354
            |     .....:..|.|......|....|:|. :......|::|......|   |:.:.:|.:..
Zfish   191 SMLAYMNANLTFFNQGHDLFSQLQPLMKQLSGQLDQLVVDSAKEKRDMEQK---HSSIQQKAALQ 252

  Fly   355 SIQALKSPITKR-PPSTPVTLSGWLHKQGSDGLKVWRKRWFVLAEYCLYYYKGPEEEKLLGSVLL 418
            ......|.:... .....:.:.|:|.|:.|:..|.|.:|||.:....|.|.|...:..   :|::
Zfish   253 DFSTEDSKLEYNIDTDNGIAMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKRFRDNP---TVVV 314

  Fly   419 PSYRVSACLPEDKIYRKFAFKCEHQNMRTYWLAADNSEAMMQWVRALAAASLMQAPSSGESE-PS 482
            ...|:......:.:.|:|.|:....: ::..:.||:.:....|::|: .:|:..|....|.| .|
Zfish   315 EDLRLCTVKHCEDVERRFCFEVLSPS-KSCMMQADSEKLRQAWIKAV-QSSIASAYRENEDEIIS 377

  Fly   483 VNSSLNHSGENSDSGIHTLQ------------SHPGK------GQPTP-----------SSENTG 518
            ::...:.|..:.|||..:::            :.||.      ||..|           ..|.:|
Zfish   378 LDRQSSASLGSLDSGCESVKLVKGESALQRVLAIPGNEFCCDCGQSDPRWASINLCITLCIECSG 442

  Fly   519 ---SSGGGSGSGQPL-------------------YANAPPKPRRINDGGYSSPSPEHNEQQ---- 557
               |.|..:...:.|                   ..|...:..|..:|| ..|.|....::
Zfish   443 IHRSLGVHNSKVRSLTLDTWEPELLKLMCELGNDVINQIYEAHREENGG-KKPQPGDPRREIEAF 506

  Fly   558 ---QQHPSRRLMSPTQQ-----LYQQQQHQRSQQQQQQ--QPQQHHAIYDTRT-GHVSTALQLQQ 611
               :....|.::.||:|     :...::|.:..|...:  .|:........|| .:.|.|....|
Zfish   507 IRAKYVDKRFVLKPTEQEQMEKIMTLRKHDKRMQGNMEFLPPRPPPPTPKLRTASNASVASLSGQ 571

  Fly   612 AQQQYSL---DHLEAQFQQQQLDMEEQIARLQQ-----QRAAEEIYGEREMYMAKLMQQRQGPNG 668
            ..::.||   |.|::.|  ...|...::..|::     |.:|:   |.|||..:.       |:.
Zfish   572 EVRRDSLFCPDELDSLF--SYFDTSSKLQNLKRADSGIQNSAD---GSREMLAST-------PSS 624

  Fly   669 TYPTQQQLLQAE------RRTPDAYGR----SKQQRLFAAAAAAADYEDIYNMSQ-LAGG----- 717
            :..::..|.::|      .|:| .:.:    |....|:.|:.|.:    :.:|:| ||.|
Zfish   625 SSLSETDLPESEAAANQAERSP-VFSKLTNFSADSLLYWASCACS----LKDMAQALAHGADINW 684

  Fly   718 ----------------GGVPMSAQEALLQEAASY-------RRPLSPPSYDGSKHVPAMPQRYTP 759
                            ||..:|. |.|||.||..       |.||...:..|......:
Zfish   685 VNLEDSSRTPLIQAVQGGSLISC-EFLLQNAACVDQQDIRGRGPLHHATILGHTGQVCL------ 742

  Fly   760 NHLEASAADQLINTMDLRARTAAAI-VRPHSADF--------LEYEARAEAAAAAAAAAVAQSQQ 815
             .|:..|..   ||:|..:|:..:| |...:||.        :..|.|....|...|...:.||.
Zfish   743 -FLKRGAKQ---NTVDTDSRSPLSIAVEAANADIVTLLRLAKMNEEMRGSEGAFGQAGQYSLSQS 803

  Fly   816 ES 817
            .:
Zfish   804 HT 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	21/103 (20%)
kmr	NP_001097775.2	PH	372..469	CDD:278594	21/96 (22%)
acap2a	XP_005163306.1	BAR_ACAP2	18..217	CDD:153322	39/220 (18%)
		PH_ACAP	273..369	CDD:270070	23/100 (23%)
		PH	273..365	CDD:278594	22/96 (23%)
		ArfGap	402..520	CDD:279720	17/118 (14%)
		ANK repeat	657..686	CDD:293786	8/32 (25%)
		ANK	658..776	CDD:238125	31/132 (23%)
		Ank_2	660..754	CDD:289560	25/108 (23%)
		ANK repeat	690..721	CDD:293786	9/31 (29%)
		ANK repeat	723..754	CDD:293786	8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910