DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and ppp1r9ba

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	XP_021329200.1	Gene:	ppp1r9ba / 558232	ZFINID:	ZDB-GENE-091006-1	Length:	803	Species:	Danio rerio

Alignment Length:	1055	Identity:	197/1055 - (18%)
Similarity:	345/1055 - (32%)	Gaps:	345/1055 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1508 KTEPVYMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTETLKKKTKKRQGKD-MPDILKPA- 1570
            ||||         .|:|..:|.....:...|..:...::|.::||..|  ..|:| .|.||...
Zfish     3 KTEP---------PSAASGSTNTTLVARSASPHRNAYEAGIQSLKPVT--ANGEDGKPRILDRGR 56

  Fly  1571 ---------KSALALASDSSDADDESSRQQL-EAKKLRSRSRFSLSDTF-RPASYYLGAS----- 1619
                     |:.........|.||.|..:.| :..:|......||::.. ..|...||.:
Zfish    57 RYGSNVHRIKNMFMQMGSPGDEDDPSKPKDLDQGVRLSLPRASSLNENVDHSALLKLGGTVSERV 121

  Fly  1620 TPLNNYAESSDSEILPPPPIPASPPPMEEL-KTEEIFSSEHYDTVKRKDSNGKVNLSYEQLPKMH 1683
            :..:...|.|.|.        .|.....:| :|.:||...|                   |.:..
Zfish   122 SRFDGKTEGSSSR--------GSTAGYSKLQETRKIFEQRH-------------------LQEKQ 159

  Fly  1684 ASNTSLNLPKAVPSPTLKSSRLSLPDHFTKVRMTPQRLLVPATPPQQHHARTLSDSNYSCQLTDT 1748
            |:...:.|.|...| ..:.|||.:...|.....:..||.....|                  .|.
Zfish   160 AATNRILLKKERAS-GFQDSRLDVVVRFNGSTESLDRLDAGDCP------------------ADA 205

  Fly  1749 SSRTSSDLDLYRRRGQQQRCTSNNSLPLSSENESVEFRQRSDSELDRQRSRRPL----SQESISE 1809
            .|.|.|.|.....|..|:     ||||                   |..|..||    :..:.::
Zfish   206 VSPTVSQLSAVFERADQR-----NSLP-------------------RPSSTSPLPSHGAASTSTK 246

  Fly  1810 IESLSEQFEETLSSHELDTYLSHLHLSTGQA---TPTSHLLNDANAAAGADILTNLIKPPKT--- 1868
            :|.:|.:                  .:|.:|   .||.:  |:|...|||.      ..||:
Zfish   247 VEGISSK------------------TATKKARSIPPTEN--NEAKDQAGAP------GSPKSRTS 285

  Fly  1869 ----FRNAEDEEQHFYGNIHFLSSTDSIQQLGEAGATALRIIHSRNNSNISTQSAPYYYSELPAP 1929
                ..|::..|....||...:|.::.|  |..:|.      .|:...|          ||..:|
Zfish   286 SQPDASNSKPSEDTASGNTDNISRSEEI--LNSSGC------DSKQGEN----------SEPGSP 332

  Fly  1930 PPLNN--QRDIHAHGLN--IAHIHNPIDRHQFNVDALVDKDQAIDSKNIYCGQKDNN-EKLSNKN 1989
            .|.:.  |.|:||...|  ....|:|.::.:...:|              |.::::: |.:|..:
Zfish   333 DPGSRLVQADVHASLENGEATSSHDPSEQKEETEEA--------------CAEEESHREDISEAD 383

  Fly  1990 LKLNKSVDLPAEMEGSGSSGGALNPVVHSYLTTTKNTNLARKTIGGSNPSDDGNPNEDGAGENTE 2054
            |     ||:.| ..|.|...                        |||...||....:|.|.|...
Zfish   384 L-----VDISA-YSGIGEDS------------------------GGSQLDDDEEAEDDDAYEPES 418

  Fly  2055 EAGKTPSNNVHTNLSVLGGELLWEEDALWRESLRRVSQRHARSLDDLDRITAAPPISSTPKAKLS 2119
            ...:.|.              |..||                         ..||         |
Zfish   419 SCSEIPG--------------LPAED-------------------------EPPP---------S 435

  Fly  2120 REVTYVNDSLKPRQHPHITNEHDVYVQLMDTTSSSHDHDQTDSDV--------YEVLREETASNL 2176
            |::.:..:.:|                 :.||.|:.|:|:.:.:|        ||:  |:....|
Zfish   436 RKIRFSVNPIK-----------------VFTTYSNEDYDRRNDEVDPMAASAEYEL--EKRVERL 481

  Fly  2177 SHKSNELDRE-------TIRQWDAMSSGLMKSNHSGVEATGASSAHLPLTSSVRSIVQQLNNSSM 2234
            .....||:::       .|........||.|........|...:||......|..::.:::.:|:
Zfish   482 DLFPVELEKDKDGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLIVEVDGTSL 546

  Fly  2235 DDANGNPMATASISVRNVNNLPVGNLTVKP-DPSDVHQ----------------ESAFAPYY--- 2279
            .....|..|:...:........:|.  .|| :.|:|.|                |..:.||.
Zfish   547 VGVTQNFAASVLRNTSGTVKFVIGR--EKPGEQSEVAQLIQQTLEQERWQREMMEQRYNPYMEED 609

  Fly  2280 ---GGAAETKYAKNTVLTDRGL----YAANGSGLA------TSTPQNHQQFRMRHTGSRAEIDML 2331
               |..|..:..:.:.:....:    .|.|...|:      .......::.:::|..::|||..|
Zfish   610 EETGECATDEEEEMSPMFPNAIEVFDLAENEDMLSPVEMDPEKLAHKFKELQIKHAVTQAEIQQL 674

  Fly  2332 ERETSSQIRNRLRSAEGLTRAESIQRLDYLKQHLLDLERHYEKSKPLVNLVDNMVKLGSLYRNDA 2396
            :|:.:...:::||..  :.||:..|.:...|:.:..||.::.:::.|...||..:|
Zfish   675 KRKLAHAEQDKLRWR--MERAQLEQTVRENKERMEKLEGYWMEAQSLCQAVDEHLK--------- 728

  Fly  2397 NGRVQPATLDRLEFNQRMQEQQMLQE-EQQQWERLSPNQAELQVRELYQLDQLLQEESGTLQSLQ 2460
            ..:.|...|:|    :..:.:::::| :|::.|.|....|:.:.:|..:....::     .::||
Zfish   729 ETQTQYQALER----KYSKAKRLIKEYQQKEIEYLKKETAQRRAQEETEASHKVE-----TKNLQ 784

  Fly  2461 RDKEDLERALGGLRA 2475
            ....|||..:|.|::
Zfish   785 EKITDLESKVGALKS 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068
kmr	NP_001097775.2	PH	372..469	CDD:278594
ppp1r9ba	XP_021329200.1	Herpes_pp85	185..>333	CDD:332820	44/233 (19%)
		Herpes_ICP4_C	227..>459	CDD:332854	71/403 (18%)
		PDZ_signaling	486..569	CDD:238492	13/82 (16%)
		SMC_N	<635..>799	CDD:330553	37/183 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2051
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030