DRSC/TRiP Functional Genomics Resources

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Protein Alignment kmr and PPP1R9A

DIOPT Version :9

Sequence 1:NP_001097775.2 Gene:kmr / 5740131 FlyBaseID:FBgn0085412 Length:3090 Species:Drosophila melanogaster
Sequence 2:XP_011514682.1 Gene:PPP1R9A / 55607 HGNCID:14946 Length:1395 Species:Homo sapiens


Alignment Length:1750 Identity:332/1750 - (18%)
Similarity:559/1750 - (31%) Gaps:652/1750 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   964 LRSASARLPKRSGGMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERKREESMKRLLEWKQRMLQ 1028
            |||||   |.|: ....::.|..||...|..            |||:|.:|.             
Human    13 LRSAS---PHRN-AYRTEFQALKSTFDKPKS------------DGEQKTKEG------------- 48

  Fly  1029 SPLTRKGIQQG-----GSNMSAMSKL----GSNPN---ILLASTAVASGARYAPQA--------- 1072
                 :|.||.     |||::.:..|    |..||   .::|.|. ..|...:||.         
Human    49 -----EGSQQSRGRKYGSNVNRIKNLFMQMGMEPNENAAVIAKTR-GKGGHSSPQRRMKPKEFLE 107

  Fly  1073 ---GKTVLVGNG------------NGTAQGAGNPPSASGIQRSRSESQANVGPGGVVYNNYSSDD 1122
               |..|.:.:.            :|        ||.|....:|...:.:|...| ..|.||...
Human   108 KTDGSVVKLESSVSERISRFDTMYDG--------PSYSKFTETRKMFERSVHESG-QNNRYSPKK 163

  Fly  1123 E--AGTVDDDNLYSATAGRSS-------SSKT-TTKATTSQ--AIVATTTAALAITNLGSSKN-- 1173
            |  .|:...|....:.:.|.|       ||:| ....|.||  |:...|.:..||.:..:..|  
Human   164 EKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEY 228

  Fly  1174 -------LETPNQTETEA-----TPSSSSTASSTKAKFQLKPILKVHEASKTRIIQVQPKHLEER 1226
                   |..|:.|.|..     ...|:|...|.|.....:   ..|:::.|.:.:|..|     
Human   229 SVTGHYPLNLPSVTVTNLDTFGHLKDSNSWPPSNKRGVDTE---DAHKSNATPVPEVASK----- 285

  Fly  1227 PKLRLQLPKAMGNEEEQKQEDEEQENVEAEP---------VPILPKKTAPK----SPQN------ 1272
               ...|....|.|.:|.:|.|:..:.:..|         .|....|..||    |||:      
Human   286 ---STSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQLLEDA 347

  Fly  1273 -ANYVPVYNNKLVSNYENMEF---------------GKPIPESK--------IPHSNAAI----- 1308
             ||.|    .:..:..:..|.               ||.:||..        ..||:..:     
Human   348 EANLV----GREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRS 408

  Fly  1309 ---TDPEETPMLMQLKLFKEQQDQQKQQQENE--EEDLTPTAESKPIPGEEDMGAPKVIKDQKLE 1368
               :|..||         ..:||:::...||.  :.|: ..:|...:|.||::.|.:.||.....
Human   409 RYNSDWGET---------GTEQDEEEDSDENSYYQPDM-EYSEIVGLPEEEEIPANRKIKFSSAP 463

  Fly  1369 -------SNEEEQELEDEDDSTACE-EYTDDDIDEAL------AQDDED-------------EAV 1406
                   |||:.....||.|..|.. ||..:...|.|      .:.|||             :|.
Human   464 IKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAG 528

  Fly  1407 VEAV------ESQELAEERELQQIYVNEPITPTD--------QQFDESHYLPMTPKKVE--LG-- 1453
            :|.:      .::..|.:|: .:|.||:.|...|        |.| .:..|..|...|.  :|  
Human   529 LEKLGIFVKTVTEGGAAQRD-GRIQVNDQIVEVDGISLVGVTQNF-AATVLRNTKGNVRFVIGRE 591

  Fly  1454 QPG----VLTLVSATYAEEEE-----ENHYVEMTKGIQDEDCRSNYEIMCLASTSSSAFKVTTKT 1509
            :||    |..|:|.|..:|..     |.||.:.... .||....::.    .|...||....|:.
Human   592 KPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDAD-DDEVAMEDFN----KSLRQSALFHDTRG 651

  Fly  1510 EPVYMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTETLKKKT-KKRQGKDM---------- 1563
            ..| .||.|:          ..:|::..:...|..:..|:..:.:. ....|.||          
Human   652 NTV-AELQGM----------SGNCNNNNNYFLKTGEYATDEEEDEVGPVLPGSDMAIEVFELPEN 705

  Fly  1564 PDILKPA----------------KSALA------LASDSSDADDESSRQQLEAKKLRSRSRFSLS 1606
            .|:..|:                |.|:.      |.:....|::|..|.:||..:|:.....:..
Human   706 EDMFSPSELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKE 770

  Fly  1607 DTFRPASYYLGAST---PLNNYAESSDSEILPPPPIPASPPPMEEL--KTEEI---FSSEHYDTV 1663
            ...:..||::.|.|   .:|.:.:.:.|:.          ..:|:.  |.:::   |..:..|.:
Human   771 RMLKLESYWIEAQTLCHTVNEHLKETQSQY----------QALEKKYNKAKKLIKDFQQKELDFI 825

  Fly  1664 KRKDSNGKVNLSYEQLPKMHASNTSLNLPKAVPSPTLKSSRLSLPDHFTKVRMTPQRLLVPATPP 1728
            ||:::..|   ..|.|.|.|...             ::..::.:.|...:|    .|||      
Human   826 KRQEAERK---KIEDLEKAHLVE-------------VQGLQVRIRDLEAEV----FRLL------ 864

  Fly  1729 QQHHARTLSDSNYSCQLTD----TSSRTSSDLDLYRRRGQQQRCTSNNSLPLSSENESVEFRQRS 1789
            :|:..:..:::|...:.|.    :...|..:||     |:|..|....|..|   ||:|...:|.
Human   865 KQNGTQVNNNNNIFERRTSLGEVSKGDTMENLD-----GKQTSCQDGLSQDL---NEAVPETERL 921

  Fly  1790 DSEL-----------DRQRSRRPLSQESISEIESLSEQFEETLSSHELDTYLSHLHLSTGQATPT 1843
            ||:.           .|||..|....:|:|..:.     |::|.....:::.:|:|         
Human   922 DSKALKTRAQLSVKNRRQRPSRTRLYDSVSSTDG-----EDSLERKPSNSFYNHMH--------- 972

  Fly  1844 SHLLNDANAAAGADILTNLIKPPKTFRNAEDEEQH-------FYGNIHFLSSTDSIQQLGEA--- 1898
                           :|.|: |||..|.:..|...       ...|:.|  |:|.|.:..|.   
Human   973 ---------------ITKLL-PPKGLRTSSPESDSGVPPLTPVDSNVPF--SSDHIAEFQEEPLD 1019

  Fly  1899 ----------GATALRIIHSRNNSNISTQSAPYYYSELPAPPPLNNQRDIHAHGLNIAHIHNPID 1953
                      |.|:|          .||..:.:...|.|.                         
Human  1020 PEMGPLSSMWGDTSL----------FSTSKSDHDVEESPC------------------------- 1049

  Fly  1954 RHQ-FNVDALVDKDQAIDSKNIYCGQKDNNEKLSNKNLKL-NKSVDLPAEMEGSGSSGGALNPVV 2016
            .|| .|...|.:||.|.|.|::..     :..|:.:..|: .|.|||.|.:..:.|.|       
Human  1050 HHQTTNKKILREKDDAKDPKSLRA-----SSSLAVQGGKIKRKFVDLGAPLRRNSSKG------- 1102

  Fly  2017 HSYLTTTKNTNLARKTIGGSNPSDDGNPNEDGAGENTEEAGKTPSNNVHTNLSVLGGELLWEEDA 2081
                         :|                                                  
Human  1103 -------------KK-------------------------------------------------- 1104

  Fly  2082 LWRESLRRVSQRHARSLDDLDRITAAPPISSTPK----AKLSRE-----VTYVNDSLKPRQHPHI 2137
             |:|..:..|:..|.|     ||......:.|||    |:.|..     .::.|||.|....   
Human  1105 -WKEKEKEASRFSAGS-----RIFRGRLENWTPKPCSTAQTSTRSPCMPFSWFNDSRKGSYS--- 1160

  Fly  2138 TNEHDVYVQLMDTTSSSHDHDQTDSDVYEVLREETASNLSHKSNELDRETIRQWDAMSSGLMKSN 2202
                  :..|...|||.....:|      ::.::..|.:.:           .|      :.|:|
Human  1161 ------FRNLPAPTSSLQPSPET------LISDKKGSKVEN-----------TW------ITKAN 1196

  Fly  2203 HSGVEATGAS--SAHLPLTSSVRSIVQQLNNSSMDDANGNPMATASISVRNVNNLPVGNLTVKPD 2265
            ......:.:|  ..|..|.|.|  .:|:.||.:.:| :.:|.:|:|..:                
Human  1197 KRNPNPSSSSIFGRHSQLMSVV--WIQETNNFTFND-DFSPSSTSSADL---------------- 1242

  Fly  2266 PSDVHQESAFAPYYGGAAETKYAKNTVLTDRGLYAANGSGLATSTPQNHQQFRMRHTGSRAEIDM 2330
                                                :|.|....||...|...:   .|...:|.
Human  1243 ------------------------------------SGLGAEPKTPGLSQSLAL---SSDEILDD 1268

  Fly  2331 LERETSSQIRNRLRSAEGLTRAESIQRLDY------LKQHLLDLERHYEKSKPLVNLVDNMVK-L 2388
            .:....||.:||      ..:..|:|::.:      |:|::.:........:.|:.|..|.:| |
Human  1269 GQSPKHSQCQNR------AVQEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKAL 1327

  Fly  2389 GSLYRNDANGRVQPATLDRLEFNQRMQEQQM-LQEEQQQWERLSPNQAELQVRELYQLDQ 2447
            |           ..|:.||....::::|.:| |::.::..|::...:.:|:.:|..|:.:
Human  1328 G-----------MTASQDRAVVKKKLKEMKMSLEKARKAQEKMEKQREKLRRKEQEQMQR 1376

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kmrNP_001097775.2 PH_PEPP1_2_3 366..469 CDD:270068
PH 372..469 CDD:278594
PPP1R9AXP_011514682.1 PDZ 501..592 CDD:214570 18/92 (20%)
TelA 709..>853 CDD:283473 27/169 (16%)
Tankyrase_bdg_C 918..>966 CDD:291973 11/52 (21%)
SAM_Neurabin-like 1279..1348 CDD:188911 16/85 (19%)
SAM 1282..1346 CDD:197735 14/74 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2051
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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