DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and PLEKHA5

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	NP_001243399.1	Gene:	PLEKHA5 / 54477	HGNCID:	30036	Length:	1282	Species:	Homo sapiens

Alignment Length:	1650	Identity:	307/1650 - (18%)
Similarity:	517/1650 - (31%)	Gaps:	613/1650 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 RHKNDLQTPGSEHGT-----VYIQQN-------HP----------NHVVNQACQTQISAVKPKAT 328
            |...||.|...|..|     .||..|       ||          ..|||:.....:::.:.|..
Human    53 RQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKER 117

  Fly   329 PSS---EESSSNSTKSPS-H--APLDRKKSAGSIQ---ALKSPITKRPPSTPVTLSGWLHKQGSD 384
            |.|   |.|:.|.|...: |  :|:.|...|....   ..:|...||.|:.||...|||:||.|.
Human   118 PISMINEASNYNVTSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDST 182

  Fly   385 GLKVWRKRWFVLAEYCLYYYKGPEEEKLLGSVLLPSYRVSACLPEDKIYRKFAFKCEHQNMRTYW 449
            |:|:|:||||||::.||:||:..:||.:|||:||||::::....||.|.||:|||..|.|||||:
Human   183 GMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYY 247

  Fly   450 LAADNSEAMMQWVRALAAASLMQAPSSGESEPSVNSSLNHSGENSDSGIHTLQSHPGKGQPTPSS 514
            ...|..:.|..|::|:..|:|:|      :||....:.|...:...|
Human   248 FCTDTGKEMELWMKAMLDAALVQ------TEPVKRITFNFRVDKITS------------------ 288

  Fly   515 ENTGSSGGGSGSGQPLYANAPPKPRRINDGGYSSPSPEHNEQQQQHPSRRLMSPTQQLYQQQQHQ 579
                             .|||.|.        ::..|.|         |.|:.|
Human   289 -----------------ENAPTKE--------TNNIPNH---------RVLIKP----------- 308

  Fly   580 RSQQQQQQQPQQHHAIYDTRTGHVSTALQLQQAQQQYSLDHLEAQFQQQQLDMEEQIARLQQQRA 644
                                        ::|..|:                  .::::::::::|
Human   309 ----------------------------EIQNNQK------------------NKEMSKIEEKKA 327

  Fly   645 AEEIYGEREMYMAKLMQQRQGPNGTYPTQQQLLQAERRTPDAYGRSKQQRLFAAAAAAADYEDIY 709
                                            |:||:     ||..|
Human   328 --------------------------------LEAEK-----YGFQK------------------ 337

  Fly   710 NMSQLAGGGGVPMSAQEALLQEAASYRRPLSPPSYDGSKHVPAMPQRYTPNHLEASAADQLINT- 773
                         ..|:..|.:..|.:....|..|:.....||....|.|.:| :|:.::::|.
Human   338 -------------DGQDRPLTKINSVKLNSLPSEYESGSACPAQTVHYRPINL-SSSENKIVNVS 388

  Fly   774 -MDLRARTAAAIVRPHSADFLEYEARAEAAAAAAAAAVAQSQQESGRAPRPKSSLDINRTPDSFY 837
             .|||                                       .|..|        |..|   .
Human   389 LADLR---------------------------------------GGNRP--------NTGP---L 403

  Fly   838 YSEASYADKMRKSA------LYLQSGGAGAAQPQQPGSYRTTGADFNSGVNTIGYENPYERAYKR 896
            |:||....:...|.      :.:|.|.....:.:...||:|.               |......|
Human   404 YTEADRVIQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTL---------------PRNMPSHR 453

  Fly   897 QELLAEAQGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPPLNVHPGSIFPPSMSTQEIISKNE 961
            .:::|. ...|..::||.|::                        .|.||...:.||.:
Human   454 AQIMAR-YPEGYRTLPRNSKT------------------------RPESICSVTPSTHD------ 487

  Fly   962 QFLRSASARLPKRSGGMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERKREESMKRLLEWKQRM 1026
                                          .|.|.||....:      ..|:::|.:|.||:||.
Human   488 ------------------------------KTLGPGAEEKRR------SMRDDTMWQLYEWQQRQ 516

  Fly  1027 L---QSPLTRKGIQQGGSNM-----SAMSKLGSNPNILLASTAVASGARYAPQAGKTVLVGNGNG 1083
            .   ||.|.|.........|     ..|..:.::|    :..::|:...|:||.
Human   517 FYNKQSTLPRHSTLSSPKTMVNISDQTMHSIPTSP----SHGSIAAYQGYSPQR----------- 566

  Fly  1084 TAQGAGNPPSASG----IQRSRSESQANV-------GPGGVVYNNYSSDDEAG-TVDDDNLYSAT 1136
            |.:...:.|...|    .:|.|:....:|       .|.|:...:.|.....| |.::..|....
Human   567 TYRSEVSSPIQRGDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEELTLLLIK 631

  Fly  1137 AGRSSSSKTTTKATTSQAIVATTTAALAITNLGSSKNLE------TPNQTETEATPSSSSTASST 1195
            ..|..:..::.:..|...::.....|.:..|...|.:|:      .....|.|...:...|....
Human   632 LRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMIEN 696

  Fly  1196 KAKFQLKPIL---------KV------HEASKTRIIQVQPKHLEERPKL-RLQLPKAMGNEEEQK 1244
            .|   |:|.|         |:      .:..:..:.:.:|:.::...|| ||.....:.:..|:|
Human   697 SA---LRPQLYQQFLRQKSKISLYCLSQDEGRGTLYKYRPEEVDIDAKLSRLCEQDKVVHALEEK 758

  Fly  1245 QEDEEQENVEAEPVPILPKKTAPKSPQNANYVPV-------YNNKLVS----------------- 1285
            .:...:|....|...:...:.......|...:..       ..|.|:|
Human   759 LQQLHKEKYTLEQALLSASQEIEMHADNPAAIQTVVLQRDDLQNGLLSTCRELSRATAELERAWR 823

  Fly  1286 NYENMEFGKPIP----ESKIPH------SNAAITDPEETPMLMQLKLFKEQQDQQKQQQ------ 1334
            .|:.:|:...:.    :.::.|      .:|.|...:....|.:::...|...:.|||:
Human   824 EYDKLEYDVTVTRNQMQEQLDHLGEVQTESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIG 888

  Fly  1335 ------------ENEEEDLTPTAESKPIPGEEDM-GAPKVIKDQKLESNEEEQELEDEDDSTACE 1386
                        :||||::.|  ...|:|...|. ..|.:|           ..|..:..|..|
Human   889 MIGSKPFSTVKYKNEEEEVVP--PRPPLPRSYDFTEQPPII-----------PPLPSDSSSLLC- 939

  Fly  1387 EYTDDDIDEALAQDDEDEAVVEAVESQELAEERELQQI----------------YVNEPITPTDQ 1435
             |:...:                    .|.||:::.|:                |.:||...|..
Human   940 -YSRGPV--------------------HLPEEKKMYQVQGYPRNGSHCGPDYRLYKSEPELTTVA 983

  Fly  1436 QFDE--------------------SHY-LPMTPKKVELGQPGVLTLVSATYAEEEEENHYVEM-- 1477
            :.||                    ||: :.:.|.:.:...|...|:.|           ||.:
Human   984 EVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIAS-----------YVTLRK 1037

  Fly  1478 TKGIQD---EDCRSNYEIMCLASTSSSAFKVTTKTEPVYMELAGV-----KASSAVPATEEAHCS 1534
            ||.:.|   |..||..|.:|||.::.....|..:.|.:.......     |..:.:.|::::...
Human  1038 TKKMMDLRTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQ 1102

  Fly  1535 SGRSTLKKCKKSGTETLKKKTKK-----RQGKDMPDILKPAKSALALASDSSDADDESSRQQLE- 1593
            | .|.|:......|:|.::..|:     |:....||...||...:.|        .|:..|.::
Human  1103 S-PSNLRDNPFRTTQTRRRDDKELDTAIRENDVKPDHETPATEIVQL--------KETEPQNVDF 1158

  Fly  1594 AKKLRSRSRFSLSDTFRPASYYLGASTPLNNYAESSDSE---ILPPPPIPASPPPMEELKTEEIF 1655
            :|:|:.....|....|.|....:       |..|..|.|   ...|..:..|  |.:|.:|....
Human  1159 SKELKKTENISYEMLFEPEPNGV-------NSVEMMDKERNKDKMPEDVTFS--PQDETQTANHK 1214

  Fly  1656 SSEH--YDTVKRKDSNGKVNLSYEQLPKMHASNTSLNLPKAVPSPTLKSSRLSLPDHFTKVRMTP 1718
            ..||  .:|....|...:..:|||..|::...|.::.:....|||...:|.
Human  1215 PEEHPEENTKNSVDEQEETVISYESTPEVSRGNQTMAVKSLSPSPESSASP-------------- 1265

  Fly  1719 QRLLVPATPPQQHHARTLSDSNYSC 1743
                ||:|.||     ....|::.|
Human  1266 ----VPSTQPQ-----LTEGSHFMC 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	50/102 (49%)
kmr	NP_001097775.2	PH	372..469	CDD:278594	47/96 (49%)
PLEKHA5	NP_001243399.1	WW	12..41	CDD:278809
		WW	58..87	CDD:278809	7/28 (25%)
		PH_PEPP1_2_3	164..267	CDD:270068	50/102 (49%)
		PH	170..266	CDD:278594	47/95 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6075
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41640
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12752
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.100