DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmr and Plekha7

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	XP_038957065.1	Gene:	Plekha7 / 499249	RGDID:	1598216	Length:	1363	Species:	Rattus norvegicus

Alignment Length:	1716	Identity:	338/1716 - (19%)
Similarity:	543/1716 - (31%)	Gaps:	605/1716 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 QQQQQHRH--KNDLQTPGSEHGTVYIQQNHPNHVVNQACQTQISAVKPKATPSS--EESSSNSTK 340
            ||....||  .....:..||:  |..::.||:          :|..:....|||  .|:|:..|.
  Rat    76 QQTTTFRHPVTGQFSSENSEY--VLREEPHPH----------MSKQERNQRPSSMVSETSTAGTT 128

  Fly   341 SPSHAPLDRK--KSAGSIQAL--KSPITKRPPSTPVTLSGWLHKQGSDGLKVWRKRWFVLAEYCL 401
            |...|....|  ||:..:.:.  :....:|..:.||.:.||||||.|.|:::|::||||||:|||
  Rat   129 STLEAKPGPKIIKSSSKVHSFGKRDQAIRRNLNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCL 193

  Fly   402 YYYKGPEEEKLLGSVLLPSYRVSACLPEDKIYRKFAFK-------------------CEHQNMRT 447
            :|||...||.:|||:.||||.:|...|||:|.||::||                   .||..|||
  Rat   194 FYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYSTTTAGSQAEHSGMRT 258

  Fly   448 YWLAADNSEAMMQWVRALAAASLMQAPSS---GESEPSVNSSLNHSGENSDSGIHTLQSHPGKGQ 509
            |:.:||..|.|..||||:..|:.:.:.||   .:.|.......||:....:.|      |.|.|
  Rat   259 YYFSADTLEDMNAWVRAMNQAAQVLSRSSLKRDKVERQAMPQANHTDACQECG------HVGPG- 316

  Fly   510 PTPSSENTGSSGGGSGSGQPLYANAPPKPRRINDGGYSSPSPEHNEQQQQHPSRRLMSPTQQLYQ 574
                                   ::...|||    ||.........:|::...|     :|:...
  Rat   317 -----------------------HSRDCPRR----GYEDAIVFDRREQEEERFR-----SQRDTL 349

  Fly   575 QQQHQRSQQQQQQQPQQHHAIYDTRTGHVSTALQLQQAQQQYSLDHLEAQFQQQQLDMEEQIARL 639
            :.:..||:.:....|.:..|::....|    ..:.||||.|
  Rat   350 EGRRDRSKARSPYLPAEEDALFVDLPG----GPRGQQAQPQ------------------------ 386

  Fly   640 QQQRAAEEIYGEREMYMAKLMQQRQGPNG---TYPTQQQL-LQAERRTPDAYGRSKQQRLFAAAA 700
            :.:|.....||         :.::.|.:|   |.|.:..| ..::|:|..|     |...:|.|
  Rat   387 RAERNGLPPYG---------LGEQNGTSGYSRTAPPRANLEKHSQRKTNLA-----QTEHWAKA- 436

  Fly   701 AAADYEDIYNMSQLAGGGGVPMSAQEALLQEAASYRRPLSPPSYDGSKHVPAMPQRYTPNHLEAS 765
                        |...|..:|       |.:....:.|..|||
  Rat   437 ------------QKGDGRSLP-------LDQTLPRQGPSQPPS---------------------- 460

  Fly   766 AADQLINTMDLRARTAAAIVRPHSADFLE-YEARAEAAAAAAAAAVAQSQQESGRAPRPKSSLDI 829
                                      ||| |                |:...:.|.|...||...
  Rat   461 --------------------------FLENY----------------QTLPRNTRYPSGSSSPPP 483

  Fly   830 NRTPDSFYYSEASYADKMRKSALYLQSGGAGAAQPQQPGSYRTTGADFNSGVNTIGYENPYERAY 894
            ...|..:.|::.      |.|.|.:.|        ::..::|       .|.....||....:.:
  Rat   484 RNLPSDYKYAQD------RASHLKMSS--------EERRAHR-------DGTVWQLYEWQQRQQF 527

  Fly   895 KRQELLAEAQGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPPLNVHPGSIFP---PSMSTQEI 956
            :.....|.. |.|:.......||.|......|....|...|:||..  |...||   |....:.:
  Rat   528 RHGSPTAPI-GAGSPEFTEQGRSRSLLEVPRSISVPPSPSDIPPPG--PPRPFPPRRPHTPAERV 589

  Fly   957 ISKNEQFLRSASARL---PKRSGGMDDDYSAGNSTTTSPTGGAGASNSPQHNLDGERKREESMKR 1018
            ..|.....||....|   |:::.|.....|:.....:.|:.|.........:|.|  |..|.:..
  Rat   590 TVKPPDQRRSVDISLGGSPRKARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHG--KSLEELSL 652

  Fly  1019 LLEWKQRMLQSPLTRKGIQQGGSNMSAMSKLGSNPNILLASTAVASGARYAPQAGKTVL------ 1077
            ||...||                   ..|||.|..|..:...........|.||..|.|
  Rat   653 LLTRLQR-------------------HQSKLASVRNFAVGQLLHHYLTFPACQADDTYLQLKKDL 698

  Fly  1078 ------VGNGNGTAQGAGNPPSASGIQRSRSESQANVGPGGVVYNNYSSDDEAGTVDDDNLYSAT 1136
                  :.|         |.|..:.:.:...:|.....|
  Rat   699 EYLDLKIKN---------NEPLINVLYKVLKKSARGCRP-------------------------- 728

  Fly  1137 AGRSSSSKTTTKATTSQAI-VATTTAALAITNLGSSKNLETPNQTETEATPSSSSTASSTKAKFQ 1200
             |||.:.:...|..:.:.: :|.:...:.::.......:....:.:..|...:         |.|
  Rat   729 -GRSMTGRDLLKDRSLKPMKIAESDTDVKLSIFCEQDRILQDLEDKIRALKEN---------KDQ 783

  Fly  1201 LKPILKV-HEASKTRIIQVQPKHLEE---------------RPKL-------------RLQLPKA 1236
            |:.:|:| |.  :|...:.||:|||:               |.:|             .|:|.|
  Rat   784 LESVLEVLHR--QTEQYRDQPQHLEKITCQQRLLQEDLVHIRAELCRESTEMENAWNEYLKLEK- 845

  Fly  1237 MGNEEEQKQEDEEQ-----------------------------------------ENVEAEPVPI 1260
              :.|:.||..:||                                         :|.|.:.||:
  Rat   846 --DVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVMAGLSVNKENYRVLVGSVKNPERKTVPL 908

  Fly  1261 LPKKTAPK-SPQNANYVPVYNNKLVSNYENMEFGKPIPESKIPHSNAAITDPEETPMLMQLKLFK 1324
            .|..:.|. ||..:                    ||..:...|      |.|..||  ::::||.
  Rat   909 FPHPSVPSLSPTES--------------------KPALQPSPP------TSPVRTP--LEVRLFP 945

  Fly  1325 EQQD--QQKQQQENEEEDLTP-TAESKPIPGEEDMGAPKVIKDQKLESNEEEQELEDEDDSTACE 1386
            :.|.  ..:.......:.::| .:.:|..|..||...|:                     ....|
  Rat   946 QLQTYVPYRPHPPQLRKVVSPLQSPTKATPQAEDEAPPR---------------------PPLPE 989

  Fly  1387 EYTDDDIDEALAQDDEDEAVVEAV-------ESQELAEERELQQIYVNEPITPTDQQFDESHYLP 1444
            .|:.:|...|:.....:..::...       :|.|...:||..|. ||..:
  Rat   990 LYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQC-VNGDL-------------- 1039

  Fly  1445 MTPKKVELGQPGVLTLVSATYAEEEEENHYVEMTKGIQDEDCRSNYEIMCLASTSSSAFKVT--- 1506
                ||||          .:|..|.|                        |||.|....:.:
  Rat  1040 ----KVEL----------RSYVSEPE------------------------LASFSGDVPRPSLGL 1066

  Fly  1507 TKTEPVYMELAGVKASSAVPATEEAHCSSGRSTLKKCKKSGTETLKKKTKKRQGKDMPDILKPAK 1571
            ..:|..|..|.|...|.:....:::...:...||::...:...::   |..|           .|
  Rat  1067 VGSESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAENSSV---TFSR-----------PK 1117

  Fly  1572 SAL-ALASDSSDADDESSRQQLEAKK------LRSRSRFSLSDTFRP---ASYYLGASTPLNNYA 1626
            ||| .|.|........|:.:|||..|      :|.|.| :||...|.   ::.||  |.||
  Rat  1118 SALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKR-TLSQGERTGLLSARYL--SQPL---- 1175

  Fly  1627 ESSDSEILPPPPIPASPPPMEELKTEEIFSSEHYDTVKRKDSNGKVN--LSYEQLPKM----HAS 1685
                            |..:...|.|:.|..:..:...:.|...|..  |..:..|.|    ...
  Rat  1176 ----------------PGDLGSWKREQEFDLQLLERAAQGDRKDKEEGWLKVQATPVMELDLEPQ 1224

  Fly  1686 NTSLNLPKAVPSPTLKSSRLSLPDHFTKVRMTPQRLLVPATPP----------QQHHARTLSDSN 1740
            :..|::.:.:..|    .::|:|:.:.:|.        |..||          :....|.:...:
  Rat  1225 DYDLDINRELSKP----EKVSIPERYVEVD--------PEEPPSVEELQARYQKAEKIRNILARS 1277

  Fly  1741 YSCQLTDTSSRTSSDLDLYRRRGQQQRCTSNNSLPLSSENESVEFRQRSDSE-------LDRQRS 1798
            ..|.|.......:|..||..:..:|:|.. |.|..|:|| .|...:|.:.|.       |:::.:
  Rat  1278 SMCNLQPPGQDRNSLADLDTQMQEQERII-NISYALASE-ASQRSKQVAGSNGPMIQCALEKRGA 1340

  Fly  1799 RRPLSQESISEIESLSEQFEETLSSH 1824
            |.|....|         .::..||:|
  Rat  1341 RVPAKPAS---------SWDMALSAH 1357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	56/121 (46%)
kmr	NP_001097775.2	PH	372..469	CDD:278594	54/115 (47%)
Plekha7	XP_038957065.1	WW	10..39	CDD:395320
		WW	54..85	CDD:197736	4/8 (50%)
		PH_PEPP1_2_3	158..280	CDD:270068	56/121 (46%)
		Smc	<736..>892	CDD:224117	25/169 (15%)
		PHA03247	<901..1007	CDD:223021	27/154 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5871
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003396
OrthoInspector	1	1.000	-	-		otm45762
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12752
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.100