DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kmr and skap2

DIOPT Version :9

Sequence 1:	NP_001097775.2	Gene:	kmr / 5740131	FlyBaseID:	FBgn0085412	Length:	3090	Species:	Drosophila melanogaster
Sequence 2:	NP_956922.1	Gene:	skap2 / 368564	ZFINID:	ZDB-GENE-030616-438	Length:	341	Species:	Danio rerio

Alignment Length:	222	Identity:	48/222 - (21%)
Similarity:	76/222 - (34%)	Gaps:	30/222 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 PSSEESSSNSTKSPSHAPLDRKKSAGSIQALKSPITKRPPSTPVTLSGWLHKQGSDGL---KVWR 390
            |..:|:.:|...|......||..........:||.........|..||:|.|:..|..   ..|:
Zfish    63 PEPDEADTNDGGSLHSEQTDRDDENAYDGVQQSPPVAAQDLQAVLKSGYLEKRRKDHSFFGNEWQ 127

  Fly   391 KRWFVLAEYCLYYYKGPEEEKLLGSVLLPSY--RVSACLPEDKIYRKFAFKCEHQNMRTYWLAAD 453
            |||..|.....|||...::::..|...:..|  :::..|.:| ..|...|:....:.|.|...|.
Zfish   128 KRWCALNNSIFYYYGSEKDKQQKGEFNIVGYTVKMNNTLRKD-AKRDCCFEVSAPDKRVYQFCAA 191

  Fly   454 NSEAMMQWVRALAAASLMQAPSSG---ESEPSVNSSLNHSGEN----SDSGIHTLQSHPGKGQPT 511
            :.:...:||..:   ..:.....|   |.|...:..|:.|...    .|..|:  :..|.:..|.
Zfish   192 SEKEAKEWVEHI---DFLIKDLGGIIPEDEEEYDDCLSMSQSEVAILPDDDIY--EELPEEDVPQ 251

  Fly   512 PSSENTGSSGGGSGSGQPLYANAPPKP 538
            ||....            ...|.||.|
Zfish   252 PSKPKV------------TLVNKPPPP 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	25/107 (23%)
kmr	NP_001097775.2	PH	372..469	CDD:278594	25/101 (25%)
skap2	NP_956922.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..95		6/31 (19%)
		PH_Skap-hom_Skap2	106..211	CDD:270181	25/108 (23%)
		PH	106..208	CDD:278594	25/105 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..265		5/30 (17%)
		SH3_SKAP2	283..335	CDD:212978
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910